Lung morphometry and MMP-12 expression in rats treated with intraperitoneal nicotine

Valença, Samuel Santos; Fonseca, Adenilson de Souza da; Hora, Katia da; Santos, R. F.; Pôrto, Luís Cristóvão

doi:10.1078/0940-2993-00322

Cited by 18 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…France). The dose and the administration route were selected according to previous studies (Valenç a et al, 2004;Jana et al, 2010;Rehan et al, 2012).…”

Section: Nicotine and Green Tea Extractmentioning

confidence: 99%

Nicotine-induced reproductive toxicity, oxidative damage, histological changes and haematotoxicity in male rats: The protective effects of green tea extract

Mosbah

Yousef

Mantovani

2015

Experimental and Toxicologic Pathology

View full text Add to dashboard Cite

“…France). The dose and the administration route were selected according to previous studies (Valenç a et al, 2004;Jana et al, 2010;Rehan et al, 2012).…”

Section: Nicotine and Green Tea Extractmentioning

confidence: 99%

Nicotine-induced reproductive toxicity, oxidative damage, histological changes and haematotoxicity in male rats: The protective effects of green tea extract

Mosbah

Yousef

Mantovani

2015

Experimental and Toxicologic Pathology

View full text Add to dashboard Cite

“…Nicotine is thought to be the main component present in the smoke of tobacco, which works as a neuro-toxic and largely accounts for most of the deleterious effects (Slotkin, 2004). Various studies have been performed on humans, animals and in a number of various types of cell systems to largely examine the actions of nicotine (Pausova et al, 2003;Cooke & Bitterman, 2004;Valenca et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of Nicotine on Hematology, Lipid Profile and Liver Enzymes in Adult Male Mice (Mus Musculus)

Sharif¹

2014

Adv. Anim. Vet. Sci.

View full text Add to dashboard Cite

This study was designed to observe the effects of nicotine on various hematological parameters, lipid and hepatic profile of adult male mice. A total of 80 mice were divided into two groups; control (n=40) and experimental (n=40). Subcutaneous injections of 1 mg/kg body weight of nicotine were given to the experimental and saline solution was given to the control group. The treatment lasted for 6 weeks after which blood was collected. Using hematological analyzer, hematological parameters were assessed whereas biochemical analysis was performed by chemistry analyzer. Statistical analysis was performed on SPSS. Comparison between the groups was done by T-test. The white blood cells, Platelet, Hematocrit, mean corpuscular volume, cholesterol, triglycerides and low density lipoprotein cholesterol were found significantly higher (p≤0.05) in an experimental group compared to control group while the significant decrease was observed in red blood cell count, hemoglobin, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, high density lipoprotein cholesterol and HDL-C/LDL-C ratio in the experimental group. Significant increase in the liver enzymes, alanine amino transferase aspartate aminotransferase and alkaline phosphatase were observed, whereas total bilirubin (mg/dl), albumin and total protein showed significant decrease in the experimental group. It is concluded that nicotine administration in mice resulted in deleterious effects on various hematological and biochemical parameters. All copyrights reserved to Nexus® academic publishers

show abstract

“…Nicotine is an amine composed of pyridine and pyrrolidine rings (Trushin & Hecht, 1999). It has been shown that nicotine can cross the biological membranes including the blood brain barrier (Balfour et al, 2000).The actions of nicotine have been extensively investigated in human, in animal, and in a variety of cell systems (Gryglewski, 1968;Ashakumary & Vijayammal, 1997;Benowitz & Gourlay, 1997;Benowitz et al, 2002;Pausova et al, 2003;Cooke & Bitterman, 2004;Valenca et al, 2004). The predominant effects of nicotine in the whole intact animal or human consist of an increase in pulse rate, blood pressure, increase in plasma free fatty acids and lung injury (Kavitharaj & Vijayammal, 1999;Liu et al, 2001;Benowitz et al, 2002;Pausova et al;.…”

Section: Introductionmentioning

confidence: 99%

Effects of Oral Nicotine on Rat Liver Stereology

2008

View full text Add to dashboard Cite

SUMMARY:Nicotine is the more abundant component in cigarette smoke. Because nicotine is first metabolized in the liver, our aim was to investigate the effects of nicotine on this organ by biochemical and stereological methods. Male Wistar rats were treated with oral nicotine (ON) diluted in drinking water during 32 days. The control group was treated with drinking water in the same period. Rats were sacrificed 24 hours after last day, the blood was collected and the liver was removed. Lipidogram was performed by enzymatic method and collagen fibers, fat globules and hepatocytes were count in the liver by stereological methods. We observed in control group preserved hepatocytes, with no presence of inflammatory cells. However in the ON group was possible to observe varied size of hepatocytes with cloudy cellular limits and histoarchitecture loss. Capillaries were fully of red blood cells. We observed also an increase of fat globules with small size. We observed in leucogram a reduction of leukocytes number (lymphocytes, neutrophils and monocytes) in the ON group in comparison to control group. The lipidogram showed an increase of triglycerides and total cholesterol for ON group when compared to control group. Moreover, a reduction of HDL-cholesterol was observed in ON group when compared to control group. Numerical density of hepatocytes was lesser in ON group when compared to control group. We suggest harmful effects of oral nicotine in liver induced by toxic mechanism with reduction of hepatocytes number and disturbance in lipid metabolism.

show abstract

Lung morphometry and MMP-12 expression in rats treated with intraperitoneal nicotine

Cited by 18 publications

References 21 publications

Nicotine-induced reproductive toxicity, oxidative damage, histological changes and haematotoxicity in male rats: The protective effects of green tea extract

Nicotine-induced reproductive toxicity, oxidative damage, histological changes and haematotoxicity in male rats: The protective effects of green tea extract

Effect of Nicotine on Hematology, Lipid Profile and Liver Enzymes in Adult Male Mice (Mus Musculus)

Effects of Oral Nicotine on Rat Liver Stereology

Contact Info

Product

Resources

About