Lung Neutrophilic Recruitment and IL-8/IL-17A Tissue Expression in COVID-19

Azevedo, Marina Luise Viola de; Zanchettin, Aline Cristina; Paula, Caroline Busatta Vaz de; Júnior, Jarbas da Silva Motta; Malaquias, Minéia Alessandra Scaranello; Raboni, Sônia Mara; Neto, Plínio Cézar; Zeni, Rafaela Chiuco; Prokopenko, Amanda; Borges, Nícolas Henrique; Godoy, Thiago Mateus; Benevides, Ana Paula Kubaski; Souza, Daiane Gavlik de; Baena, Cristina Pellegrino; Machado-Souza, Cleber; Noronha, Lúcia de

doi:10.3389/fimmu.2021.656350

Cited by 27 publications

(33 citation statements)

References 40 publications

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“…These findings were in line with the study conducted by Li Y et al [33]; and could lead to more common acute upper respiratory tract symptoms in hospitalized H1N1 patients [34]. A study conducted by Azevedo et al further confirmed this phenomenon; in which tissue expression increasing of IL-8/IL-17A and a higher number of neutrophils were identified in samples from the H1N1 group compared to the COVID-19 group [35]. The diverse characteristics of infection provides the rationale for advancing differential treatment efforts to improve outcomes of these two types of patients.…”

Section: Plos Neglected Tropical Diseasessupporting

confidence: 89%

“…Ct values at admission were lower in co-infected patients (median 32 [25.5-35.5]) than patients with SAR-CoV-2 monoinfection (median 36 [32][33][34][35][36][37][38]) (Fig 1), indicating higher initial viral load in co-infected patients. In the subsequent monitoring, the Ct value of the two groups have been increasingly similar.…”

Section: Analysis Of Distribution Regulation Of Ct Valuesmentioning

confidence: 99%

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Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients

Zheng

Chen

et al. 2021

PLoS Negl Trop Dis

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mimics the influenza A (H1N1) virus in terms of clinical presentation, transmission mechanism, and seasonal coincidence. Comprehensive data for the clinical severity of adult patients co-infected by both H1N1 and SARS-CoV-2, and, particularly, the relationship with PCR cycle threshold (Ct) values are not yet available. All participants in this study were tested for H1N1 and SARS-CoV-2 simultaneously at admission. Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records and compared among adults hospitalized for H1N1 infection, SARS-CoV-2 infection and co-infection with both viruses. Ct values for viral RNA detection were further compared within SARS-CoV-2 and co-infection groups. Score on seven-category ordinal scale of clinical status at day 7 and day 14 were assessed. Among patients with monoinfection, H1N1 infection had higher frequency of onset symptoms but lower incidence of adverse events during hospitalization than SAR-CoV-2 infection (P < 0.05). Co-infection had an increased odds of acute kidney injury, acute heart failure, secondary bacterial infections, multilobar infiltrates and admittance to ICU than monoinfection. Score on seven-category scale at day 7 and day 14 was higher in patients with coinfection than patients with SAR-CoV-2 monoinfection (P<0.05). Co-infected patients had lower initial Ct values (referring to higher viral load) (median 32) than patients with SAR-CoV-2 monoinfection (median 36). Among co-infected patients, low Ct values were significantly and positively correlated with acute kidney injury and ARDS (P = 0.03 and 0.02, respectively). Co-infection by SARS-CoV-2 and H1N1 caused more severe disease than monoinfection by either virus in adult inpatients. Early Ct value could provide clues for the later trajectory of the co-infection. Multiplex molecular diagnostics for both viruses and early assessment of SAR-CoV-2 Ct values are recommended to achieve optimal treatment for improved clinical outcome.

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Section: Plos Neglected Tropical Diseasessupporting

confidence: 89%

Section: Analysis Of Distribution Regulation Of Ct Valuesmentioning

confidence: 99%

Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients

Zheng

Chen

et al. 2021

PLoS Negl Trop Dis

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“…These cytokines increase vascular permeability and allow the intense neutrophilic infiltrates to give a response to viral infection. A study indicated the G allele of rs3819025 correlated with higher tissue expression of IL-17A in the COVID-19 cases [46]. In our study, serum IL17 levels of all COVID-19 cases, whether they received vitamin D supplementation or not, remained low compared with controls.…”

Section: Vitamin D and Covid-19supporting

confidence: 40%

“…As seen in COVID-19, the innate immune response stimulates the release of both pro-inflammatory and anti-inflammatory cytokines in response to viral and bacterial infections [2]. Vitamin D levels are associated with cytokines such as IL-1, IL-6, IL-10, and TNFα [5]; additionally, vitamin D can reduce pro-inflammatory TH1 cytokines such as TNFα and IFNg, and increase anti-inflammatory cytokines released from macrophages [45][46][47]. In this respect, it is known that it can also regulate the adaptive immune response [14].…”

Section: Vitamin D and Covid-19mentioning

confidence: 99%

Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

et al. 2021

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Background: We aimed to establish an acute treatment protocol to increase serum vitamin D, evaluate the effectiveness of vitamin D3 supplementation, and reveal the potential mechanisms in COVID-19. Methods: We retrospectively analyzed the data of 867 COVID-19 cases. Then, a prospective study was conducted, including 23 healthy individuals and 210 cases. A total of 163 cases had vitamin D supplementation, and 95 were followed for 14 days. Clinical outcomes, routine blood biomarkers, serum levels of vitamin D metabolism, and action mechanism-related parameters were evaluated. Results: Our treatment protocol increased the serum 25OHD levels significantly to above 30 ng/mL within two weeks. COVID-19 cases (no comorbidities, no vitamin D treatment, 25OHD <30 ng/mL) had 1.9-fold increased risk of having hospitalization longer than 8 days compared with the cases with comorbidities and vitamin D treatment. Having vitamin D treatment decreased the mortality rate by 2.14 times. The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. Conclusions: Vitamin D treatment shortened hospital stay and decreased mortality in COVID-19 cases, even in the existence of comorbidities. Vitamin D supplementation is effective on various target parameters; therefore, it is essential for COVID-19 treatment.

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“…Among its functions, IL-8 contributes to induce endothelial permeability by inducing the expression of integrins, enabling neutrophils to pass through vessels to reach inflammation sites [38] and preventing clot formation [39].…”

Section: Discussionmentioning

confidence: 99%

Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Children: One Year after the Onset of the Pandemic in a High-Incidence Area

Fabi

Filice

Biagi

et al. 2021

Viruses

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SARS-CoV-2 infection in children can trigger cardiovascular manifestations potentially requiring an intensive treatment and defining a new entity named Multisystem Inflammatory Syndrome in Children (MIS-C), whose features partially overlap with Kawasaki Disease (KD). A cross-sectional study including all diagnoses of MIS-C and KD from April 2020 to May 2021 in our metropolitan area was conducted evaluating clinical, laboratory (including immunological response, cytokines, and markers of myocardial damage), and cardiac (coronary and non-coronary) features at onset of the diseases. Evolution of ventricular dysfunction, valve regurgitations, and coronary lesions was documented. The severity of the disease was also considered based on the need for inotropic support and ICU admission. Twenty-four MIS-C were diagnosed (14 boys, median age 82 months): 13/24 cases (54.17%) presented left ventricular dysfunction, 12/24 (50%) required inotropic support, and 10/24 (41.67%) developed coronary anomalies (CALs). All patients received steroids and IVIG at a median time of 5 days (IQR1:4, IQR3:6.5) from onset of fever and heart function normalized 6 days (IQR1: 5, IQR3: 7) after therapy, while CALs persisted in one. One patient (12.5%) required infliximab because of refractory disease and still presented CALs 18 days after therapy. During the same study period, 15 KD were diagnosed: none had ventricular dysfunction, while 7/15 (46.67%) developed CALs. Three out of 15 patients (20%) still presented CALs 46 days from onset. Compared to KD, MIS-C pts have significantly higher IL8 and similar lymphocytes subpopulations. Despite a more severe presentation and initial cardiac findings compared to KD, the myocardial injury in MIS-C has a rapid response to immunomodulatory treatment (median time 6 days), in terms of ventricular function, valve regurgitations, and troponin. Incidence of CALs is similar at onset, but it tends to regress in most of the cases of MIS-C differently than in KD where CALs persist in up to 40% in the subacute stage after treatment.

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Lung Neutrophilic Recruitment and IL-8/IL-17A Tissue Expression in COVID-19

Cited by 27 publications

References 40 publications

Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients

Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients

Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Children: One Year after the Onset of the Pandemic in a High-Incidence Area

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