Lung Reimplantation

Alican, F; Hardy, James D.

doi:10.1001/jama.1963.63700100001013

Cited by 48 publications

(5 citation statements)

References 3 publications

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“…Despite all the improvements in transplantation technique, thrombosis of the venous anastomosis is still the most serious complication (Alican and Hardy, 1963;Hardy, Eraslan, and Webb, 1964;Borrie and Lichter, 1964;Davies et al, 1965). Even immaculate venous anastomosis may suffer thrombosis.…”

Section: Discussionmentioning

confidence: 99%

“…Many authors (Blumenstock et al, 1962;Alican and Hardy, 1963;Bulcherl et al, 1964a, b;Hardy et al, 1964) have suggested that denervation may cause a reduction in the function of the transplant. Of three possible ways in which such a reduction could take place-namely, impairment of ventilation, perfusion, or diffusion-we wish to exclude impairment of perfusion.…”

Section: Discussionmentioning

confidence: 99%

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Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.

T¹,

Trenkner²

1966

Thorax

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.

T¹,

Trenkner²

1966

Thorax

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“…The increasing success of experimental cardiac transplantation led Hardy and his colleagues, at the University of Mississippi Medical Centre, to consider heart transplantation in man. This group had considerable experience in the field of animal studies, both of cardiac transplantation (Webb andHoward, 1957a, 1957b;Webb et al, 1959Webb et al, , 1961Lee andWebb, 1958, 1959;Hardy et al, 1964a;Kurrus et al, 1964) and of lung transplantation (Hardy et al, 1963a(Hardy et al, , 1963bAlican and Hardy, 1963), and had carried out lung homotransplantation in man on one occasion (Hardy et al, 1963c).…”

Section: Cardiac Transplantation In Man-first Attemptmentioning

confidence: 99%

Experimental development of cardiac transplantation.

Cooper¹

1968

BMJ

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“…DENERVATION of all functional pulmonary tissue in the dog is accompanied by abolition of the Hering-Breuer reflex, which leads to slow deep respiration incompatible with prolonged satisfactory existence (Alican and Hardy, 1963). Thus lung-grafts are usually implanted in animals which have some normally functioning pulmonary tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Another mode of assessment of the function of reimplanted lungs, but rather less precise, was that of Alican and Hardy (1963). In their investigations 33 of a series of 68 dogs with reimplanted lungs were subjected to further operative procedures.…”

Section: Introductionmentioning

confidence: 99%

Development of cervical bronchostomy in relation to canine pulmonary transplantation

Jones

1967

Journal of British Surgery

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This short series gives some support to the view that limited excision with postoperative radiotherapy is a form of treatment worthy of consideration. The efficacy of radiotherapy is inversely proportional to the volume of the tumour. It is logical to consider, as has been done particularly with carcinoma of the breast, that local excision and radiotherapy may be preferable to either treatment by itself. Two of our patients are of interest in this connexion. One (Case 9) had local recurrence which was apparently eradicated by radiotherapy. The other (Case IO), in whom there was histological evidence of inadequate excision, did not develop recurrence at the anastomosis.Surgical treatment for oesophageal carcinoma should achieve freedom from dysphagia. A disadvantage of limited excision with end-to-end anastomosis is that the incidence of postoperative dysphagia is probably greater than with other procedures. The method carries not only the risk of local recurrence but also the risk of dysphagia from fibrous stricture formation at the suture line. Dysphagia may, of course, occur from peptic stricture following oesophagogastrostomy but is rare after oesophagojejunostomy. When a stricture does form after end-to-end oesophageal anastomosis it is often web-like and responds well to dilatation.The operation, therefore, has certain disadvantages. It is limited in its application, being suitable only for the somewhat rare, small hard growth. The operation contravenes the rule of wide excision in cancer surgery. It is probably associated with a higher incidence of postoperative dysphagia than oesophagogastrostomy or oesophageal replacement with jejunum or colon.It has advantages. It is a relatively short procedure and, when practicable, is suitable for very old and very ill patients. When it is successful the patient is left with a normal alimentary tract, apart from the possible effects of vagotomy. His nutrition is excellent. He does not suffer from anaemia of either sideropenic or megaloblastic type. There are no late sequelae from derangement of calcium metabolism. He does not suffer from oesophagitis. The 3 long survivors in the present series are the best results of surgery for oesophageal cancer which the author has achieved by any type of operation.It cannot be overemphasized that any attempt to extend the indications for this operation is doomed to failure. SUMMARY Ten patients are described in whom a carcinoma of the oesophagus was resected with end-to-end oesophageal anastomosis. In 4 patients the operation was combined with postoperative radiotherapy.The selection of suitable cases is outlined. A technique of anastomosis is described.The advantages and disadvantages of the operation are discussed.

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Lung Reimplantation

Cited by 48 publications

References 3 publications

Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.

Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.

Experimental development of cardiac transplantation.

Development of cervical bronchostomy in relation to canine pulmonary transplantation

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