Lung tissue volume estimated by simultaneous radiographic and helium dilution methods.

Armstrong, J D; Glück, E; Crapo, Robert O.; Jones, H.; Hughes, J. M. B.

doi:10.1136/thx.37.9.676

Cited by 33 publications

(17 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Armstrong et al report that at FRC tissue accounts for 19% of total lung volume (2). For each subject, 1 liter was subtracted from the measured lung volume at FRC ϩ 1, and 19% of this value was taken as the lung tissue volume for that subject.…”

Section: Methodsmentioning

confidence: 99%

Morphometric changes in the human pulmonary acinus during inflation

Hajari¹,

Yablonskiy

Sukstanskiı̆

et al. 2012

Journal of Applied Physiology

View full text Add to dashboard Cite

Despite decades of research into the mechanisms of lung inflation and deflation, there is little consensus about whether lung inflation occurs due to the recruitment of new alveoli or by changes in the size and/or shape of alveoli and alveolar ducts. In this study we use in vivo (3)He lung morphometry via MRI to measure the average alveolar depth and alveolar duct radius at three levels of inspiration in five healthy human subjects and calculate the average alveolar volume, surface area, and the total number of alveoli at each level of inflation. Our results indicate that during a 143 ± 18% increase in lung gas volume, the average alveolar depth decreases 21 ±5%, the average alveolar duct radius increases 7 ± 3%, and the total number of alveoli increases by 96 ± 9% (results are means ± SD between subjects; P < 0.001, P < 0.01, and P < 0.00001, respectively, via paired t-tests). Thus our results indicate that in healthy human subjects the lung inflates primarily by alveolar recruitment and, to a lesser extent, by anisotropic expansion of alveolar ducts.

show abstract

Section: Methodsmentioning

confidence: 99%

Morphometric changes in the human pulmonary acinus during inflation

Hajari¹,

Yablonskiy

Sukstanskiı̆

et al. 2012

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…The experiment was done on euthanized pigs; hence, ϕ was constant. Previous studies [42, 58] suggest that the lung air volume fraction ϕ = 75 % [1], the lung tissue density ρ p = 1000 kg/m 3 , and the air density in the lung ρ g = 1.21 kg/m 3 . Hence, the composite lung parenchymal density would be given by:

ρ = ϕ ρ_{p} + false(1 - ϕ false) ρ_{t}

…”

Section: Methodsmentioning

confidence: 99%

Sound transmission in porcine thorax through airway insonification

Peng

Dai

Mansy

et al. 2015

Med Biol Eng Comput

View full text Add to dashboard Cite

Many pulmonary injuries and pathologies may lead to structural and functional changes in the lungs resulting in measurable sound transmission changes on the chest surface. Additionally, noninvasive imaging of externally driven mechanical wave motion in the chest (e.g., using magnetic resonance elastography) can provide information about lung structural property changes and, hence, may be of diagnostic value. In the present study, a comprehensive computational simulation (in silico) model was developed to simulate sound wave propagation in the airways, lung, and chest wall under normal and pneumothorax conditions. Experiments were carried out to validate the model. Here, sound waves with frequency content from 50 to 700 Hz were introduced into airways of five porcine subjects via an endotracheal tube, and transmitted waves were measured by scanning laser Doppler vibrometry at the chest wall surface. The computational model predictions of decreased sound transmission with pneumothorax were consistent with experimental measurements. The in silico model can also be used to visualize wave propagation inside and on the chest wall surface for other pulmonary pathologies, which may help in developing and interpreting diagnostic procedures that utilize sound and vibration.

show abstract

“…Direct measurements volume was derived from tissue weight, on the of the diameters of included and excluded vessels, assumption that air free lung tissue has a specific made with a pair of screen cursors, showed that the gravity of 1 -04. The reproducibility of this technique boundary excludes any blood vessels with diameters was checked by applying it on 10 occasions to one 12 subjects withfibrosing alveolitis (squares) and in 12 with chronic airflow limitation (triangles). SLC predicted represents 47-5% ofthe plethysmographic measure oftotal lung capacity apportioned to the left lung and the remainder to the right lung.8 The mean (SD) error in SLCct was 370 (381) ml.…”

mentioning

confidence: 99%

“…Fig5 A comparison ofactual and interpolated estimates of the area ofcomputed tomography slices ofsingle lungs in (left handpanel) 12 subjects withfibrosing alveolitis (squares) and in (right handpanel)12 subjects with chronic airflow limitation (triangles). In practice, departuresfrom the line ofidentity will on average befour times less than those shown here.…”

mentioning

confidence: 99%

Computed tomography based estimates of regional gas and tissue volume of the lung in supine subjects with chronic airflow limitation or fibrosing alveolitis.

Millar¹,

Fromson²,

Strickland³

et al. 1986

Thorax

View full text Add to dashboard Cite

Twelve patients with chronic airflow limitation and 12 patients with a histological diagnosis of fibrosing alveolitis were studied. The calculated mean (SD) tissue volume of a single lung at total lung capacity was 467 (91) ml in the patients with alveolitis, which was 43% (14%) more than predicted for healthy people of the same age, sex, and height. The tissue volume of a single lung at total lung capacity was 436 (82) ml in the patients with chronic airflow limitation, which was 26% (21%) more than predicted. At residual volumes the tissue contents of the fibrotic and the obstructed lungs changed very little (to 407 (84) ml and 433 (84) ml respectively). This allowed tissue volume to be used as a marker of position within the lung, to match inspiratory and expiratory slices and to calculate regional ventilation. In both groups local ventilation was diminished and more variable than in healthy lungs-that is, in the mid 70% of lung volume the local residual volume to total gas volume ratios (RV/TGV) were 32% (10%) in the fibrotic group and 66% (14%) in the group with chronic airflow limitation, compared with 23% (5%) in healthy subjects. As expected, the fibrotic lungs were much denser (0-246 (0036) g/ml) and the lungs with chronic airflow obstruction were less dense (0-114 (0-026) g/ml) than were healthy lungs (0-126 (0-017) g/ml).We have previously shown that computed tomography could measure the total gas and tissue volumes and the regional vital capacities and residual volumes of the lungs in healthy men.' The aim of the present study was to discover how well computed tomography could recover the same volumes in patients with lung disease. MethodsWe studied 12 patients with chronic airflow limitation and 12 patients with fibrosing alveolitis. They were chosen from larger groups of patients with probable emphysema or fibrosis in whom computed tomography had been performed for clinical reasons. Their scans, which were stored on magnetic tape, were selected for more detailed study retrospectively, on the basis of clinical, radiographic, functional, and (in the case of fibrosing alveolitis) histological confirmation of the diagnosis.

show abstract

Lung tissue volume estimated by simultaneous radiographic and helium dilution methods.

Cited by 33 publications

References 10 publications

Morphometric changes in the human pulmonary acinus during inflation

Morphometric changes in the human pulmonary acinus during inflation

Sound transmission in porcine thorax through airway insonification

Computed tomography based estimates of regional gas and tissue volume of the lung in supine subjects with chronic airflow limitation or fibrosing alveolitis.

Contact Info

Product

Resources

About