Abstract:Lung transplantation for CF is associated with acceptable survival rates and can improve quality of life. Lung transplant should be offered to all patients with advanced CF lung disease if they meet currently accepted inclusion and exclusion criteria.
“…[11][12][13][14] Multi-institutional studies have generally focused on outcomes related to many cohorts of LTx patients and not just those with one diagnosis such as CF. 6 An important exception was a recent study by Liou and colleagues utilizing data from the United States CF Foundation Patient Registry and UNOS to examine outcomes in pediatric patients with CF.…”
Section: Cystic Fibrosis and Lung Transplantationmentioning
“…[11][12][13][14] Multi-institutional studies have generally focused on outcomes related to many cohorts of LTx patients and not just those with one diagnosis such as CF. 6 An important exception was a recent study by Liou and colleagues utilizing data from the United States CF Foundation Patient Registry and UNOS to examine outcomes in pediatric patients with CF.…”
Section: Cystic Fibrosis and Lung Transplantationmentioning
“…6 Further refinements in the technique, medications and selection criteria have significantly improved post-surgical survival and survival benefit for CF lung transplant patients. [7][8][9][10] Currently, this approach is used widely for the treatment of end-stage CF lung disease. 11 An interesting question has arisen as to whether replacing the diseased CF lung with a normal lung is sufficient to prevent persistent lung infections.…”
“…Since prospective studies with randomization are for obvious reasons not ethically possible only retrospective studies with inherent methodological flaws are available. While some centres report no adverse effect on outcome measures including 5-year survival 22 others show significantly worse immediate post-transplant outcomes like early graft dysfunction and prolonged mechanical ventilation as well as higher 1-year mortality. 23 Possible explanations for this discrepancy include selection bias, differences in treatment protocols and timing of transplant.…”
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