Lung Transplantation for Non-Cystic Fibrosis Bronchiectasis: Analysis of a 13-Year Experience

Beirne, Paul; Banner, Nicholas R.; Khaghani, Asghar; Hodson, Margaret E.; Yacoub, Magdi H.

doi:10.1016/j.healun.2004.12.114

Cited by 29 publications

(24 citation statements)

References 13 publications

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“…In a case series of 22 patients transplanted in the UK between 1988 and 2001 undergoing bilateral lung transplantation either as bilateral sequential single-lung transplants (BSSLTX), heart-lung transplants (HLTX) or single-lung transplants (SLTX) the reported outcomes included lung function and mortality data. 242 Overall the 1 year Kaplan-Meier survival for all patients was 68% (95% CI, 54% to 91%), with the 5 year survival reaching 62% (95% CI, 41% to 83%). In those undergoing SLTX for bronchiectasis the 1 year survival was lower at 57% (95% CI, 20% to 94%) compared with those receiving 2 lungs 73% (95% CI, 51% to 96%).…”

Section: Sectionmentioning

confidence: 89%

British Thoracic Society Guideline for bronchiectasis in adults

Hill

Sullivan

Chalmers

et al. 2018

Thorax

379

348

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Section: Sectionmentioning

confidence: 89%

British Thoracic Society Guideline for bronchiectasis in adults

Hill

Sullivan

Chalmers

et al. 2018

Thorax

379

348

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“…Nonetheless, bilateral lung transplantation is widely accepted in this patient population, with the assumption that infection in the contralateral native bronchiectatic lung would threaten single-lung transplantation [47]. The current medical literature includes only one study that has examined lung transplantation for NCFB [48]. This study included 22 patients (12 males, 10 females) with an average age of 43.4 years (range 20-58) years who underwent lung transplantation for this condition over a 13-year period.…”

Section: Lung Transplantationmentioning

confidence: 99%

Non-cystic fibrosis bronchiectasis

Neves

Guerra

Ponce

et al. 2011

Interactive CardioVascular and Thoracic Surgery

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Bronchiectasis is characterized by irreversible widening of the medium-sized airways, with inflammation, chronic bacterial infection and destruction of the bronchial walls. Exercise or inspiratory muscle training may improve quality of life and exercise endurance in people with non-cystic fibrosis bronchiectasis. Prolonged-use antibiotics improve clinical response rates, but may not reduce exacerbation rates or lung function. Surgery is often considered for people with extreme damage to one or two lobes of the lung who are at risk for severe infection or bleeding. In this review, the authors will focus on non-cystic fibrosis bronchiectasis, pointing out the differences in management when compared with the cystic fibrosis context, with special emphasis on surgical management.

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“…There have been several published series reporting outcome after transplantation for non-cystic fibrosis bronchiectasis [10,11]; however, the reported experience of lung transplantation in patients with CVID in particular, remains small. In the study by Nathan et al [11], 5 out of a series of 37 patients with bronchiectasis had demonstrable antibody deficiency pre-transplantation (and only 1 of these had a pre-transplant diagnosis of CVID, which coincidentally was the same patient described by Yeatman and Hill et al, above).…”

Section: Discussionmentioning

confidence: 99%

“…In the study by Nathan et al [11], 5 out of a series of 37 patients with bronchiectasis had demonstrable antibody deficiency pre-transplantation (and only 1 of these had a pre-transplant diagnosis of CVID, which coincidentally was the same patient described by Yeatman and Hill et al, above). In the study of 22 patients by Bierne et al [10], 2 patients were identified with pretransplant hypogammaglobulinaemia, 1 patient with panhypogammaglobulinaemia and the other with an IgG 1 subclass deficiency. Both patients received SLTx.…”

Section: Discussionmentioning

confidence: 99%

Common variable immune deficiency and lung transplantation

Burton

Milman

Andersen

et al. 2007

Scandinavian Journal of Infectious Diseases

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We report on a male patient with bronchiectasis secondary to common variable immune deficiency (CVID) receiving lung transplantation. The patient had been diagnosed with CVID many y prior to right-sided single lung transplantation and was receiving appropriate immunoglobulin substitution therapy. He received antithymocyte globulin induction and maintenance triple therapy with cyclosporine, azathioprine and prednisolone. The early post-operative course was complicated by the development of severe acute cellular rejection and organizing pneumonia. Despite immunoglobulin replacement and antifungal prophylaxis and treatment, Aspergillus fumigatus was repeatedly cultured from bronchoalveolar lavage fluid, 18 months after transplantation. The patient died following a protracted period of repeated hospital admissions, 46 months after transplantation. A review of the literature suggests that many CVID patients appear to have had a complicated post-operative course after lung- and other solid-organ transplantation, and highlights the need for the establishment of international registries for transplanted patients with uncommon conditions.

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Lung Transplantation for Non-Cystic Fibrosis Bronchiectasis: Analysis of a 13-Year Experience

Cited by 29 publications

References 13 publications

British Thoracic Society Guideline for bronchiectasis in adults

British Thoracic Society Guideline for bronchiectasis in adults

Non-cystic fibrosis bronchiectasis

Common variable immune deficiency and lung transplantation

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