Lung Ultrasound Surface Wave Elastography for Assessing Interstitial Lung Disease

Zhang, Xiao Ming; Zhou, Boran; Osborn, Thomas G.; Bartholmai, Brian J.; Kalra, Sumit

doi:10.1109/tbme.2018.2872907

Cited by 24 publications

(17 citation statements)

References 58 publications

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“…Given the relatively small size of mouse lungs, high‐frequency ultrasound was used in this study to evaluate the regularity and degree of pulmonary fibrosis in mice ex vivo based on ultrasound images. The ultrasound technique has the advantage of being portable, noninvasive, and inexpensive when integrated with the clinical grading and texture analysis and can be used for early screening of mice, as well as, longitudinal monitoring 34 . The texture analysis can be performed by imaging algorithms and together with a physician's visual grading to improve the assessment of pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Grading Bleomycin‐Induced Pulmonary Fibrosis in ex vivo Mouse Lungs Using Ultrasound Image Analysis

Zhou

Shao

Schaefbauer

et al. 2020

J of Ultrasound Medicine

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Objectives The aim of this study was to assess bleomycin‐induced pulmonary fibrosis on ex vivo mouse lungs using ultrasound image grading and texture analysis. Methods Excised mouse lungs were divided into 3 groups: control, mild fibrosis, and severe fibrosis based on the monitored indicators of health. B‐mode ultrasound images were obtained via scanning the mouse lungs ex vivo. The surface smoothness, echo density, and angle of lesions or the lung margin were graded, and the imaging contrast, correlation, homogeneity, and entropy were assessed via texture analysis. Results The grades of surface smoothness, echo density, and angle were statistically higher for the severe fibrosis group compared with those of the control and mild fibrosis groups (P < .05). In addition, statistically significant differences in the contrast, correlation, and homogeneity between mild and severe fibrosis groups were observed (P < .05). Conclusions The results obtained in this study suggest that ultrasound image grading and texture analysis are valuable and meaningful methods for assessing pulmonary fibrosis in a bleomycin mouse model.

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Section: Discussionmentioning

confidence: 99%

Grading Bleomycin‐Induced Pulmonary Fibrosis in ex vivo Mouse Lungs Using Ultrasound Image Analysis

Zhou

Shao

Schaefbauer

et al. 2020

J of Ultrasound Medicine

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“…A mechanical shaker was placed adjacent to the ultrasound transducer with a distance of roughly 5 mm and used to generate a wave, while the ultrasound transducer with a central frequency of 6.4 MHz was used for capturing the wave propagation of the tissue. The normal component of the lung surface motion was quantified by cross-correlation analysis of the ultrasound tracking beams [29]. Eight locations covering a length of approximately 6 mm on the lung surface were used to measure the normal component of the lung surface motion.…”

Section: Ultrasound Elastography In Lung Disease Diagnoses a Ulmentioning

confidence: 99%

Ultrasound Elastography for Lung Disease Assessment

Zhou

Yang

Zhang

et al. 2020

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Ultrasound elastography (US-E) is a noninvasive, safe, cost-effective and reliable technique to assess the mechanical properties of soft tissue and provide imaging biomarkers for pathological processes. Many lung diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and interstitial lung disease are associated with dramatic changes in mechanical properties of lung tissues. Nevertheless, USE is rarely used to image the lung because it is filled with air. The large difference in acoustic impedance between air and lung tissue results in the reflection of the ultrasound wave at the lung surface and, consequently, the loss of most ultrasound energy. In recent years, there has been an increasing interest in USE applications in evaluating lung diseases. This article provides a comprehensive review of the technological advances of USE research on lung disease diagnosis. We introduce the basic principles and major techniques of USE and provide information on various applications in lung disease assessment. Finally, the potential applications of USE to the diagnosis of COVID-19 pneumonia is discussed. Index Terms-COVID-19 pneumonia, endobronchial ultrasound elastography (US-E), lung cancer, lung disease, lung ultrasound surface wave elastography (LUSWE), pulmonary fibrosis. I. INTRODUCTION L UNG disease is one of the leading causes of death worldwide. Interstitial lung diseases (ILDs) include more than 200 diseases, such as pulmonary fibrosis, pulmonary edema, pneumonia, and so on. Idiopathic pulmonary fibrosis (IPF) is increasingly recognized as a public health concern, with more than 50 000 cases annually diagnosed [1], and lung cancer is by far the leading cause of cancer death among both men and women, making up almost 25% of all cancer deaths. Meanwhile, in 2020, the world is experiencing the Covid-19 pandemic, which has resulted in many cases of pneumonia. More than ever, accurate diagnosis and monitoring of lung diseases are concerns of global scale.

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“…However, B-line artifact analysis depends on expert interpretation and is subjective [2]. Lung ultrasound surface wave elastography (LUSWE) was developed [3][4][5][6] to measure the surface wave speed of a lung and was applied for assessing patients with interstitial lung disease (ILD) [7,8]. We studied a lung phantom sponge model using LUSWE to measure the water effects on the surface wave speed of sponges [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…We developed lung ultrasound surface wave elastography (LUSWE) [ 3 – 5 ] to measure surface wave speed of lung for assessing patients with interstitial lung disease (ILD) [ 6 , 7 ]. This research aims to develop LUSWE to accurately detect changes in lung stiffness (compliance) caused by EVLW (pulmonary edema).…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Wet Lung Using Lung Ultrasound Surface Wave Elastography in an Ex Vivo Swine Lung Model

2019

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Extravascular lung water (EVLW) is a basic symptom of congestive heart failure and other conditions. Computed tomography (CT) is standard method used to assess EVLW, but it requires ionizing radiation and radiology facilities. Lung ultrasound reverberation artifacts called B-lines have been used to assess EVLW. However, analysis of B-line artifacts depends on expert interpretation and is subjective. Lung ultrasound surface wave elastography (LUSWE) was developed to measure lung surface wave speed. This pilot study aimed at measureing lung surface wave speed due to lung water in an ex vivo swine lung model. The surface wave speeds of a fresh ex vivo swine lung were measured at 100 Hz, 200 Hz, 300 Hz, and 400 Hz. An amount of water was then filled into the lung through its trachea. Ultrasound imaging was used to guide the water filling until significant changes were visible on the imaging. The lung surface wave speeds were measured again. It was found that the lung surface wave speed increases with frequency and decreases with water volume. These findings are confirmed by experimental results on an additional ex vivo swine lung sample.

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Lung Ultrasound Surface Wave Elastography for Assessing Interstitial Lung Disease

Cited by 24 publications

References 58 publications

Grading Bleomycin‐Induced Pulmonary Fibrosis in ex vivo Mouse Lungs Using Ultrasound Image Analysis

Grading Bleomycin‐Induced Pulmonary Fibrosis in ex vivo Mouse Lungs Using Ultrasound Image Analysis

Ultrasound Elastography for Lung Disease Assessment

A Pilot Study of Wet Lung Using Lung Ultrasound Surface Wave Elastography in an Ex Vivo Swine Lung Model

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