Lung volumes and distensibility, and maximum respiratory pressures in thyroid disease before and after treatment.

Freedman, Steven J.

doi:10.1136/thx.33.6.785

Cited by 24 publications

(9 citation statements)

References 15 publications

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“…Some [233,239] but not all investigators [229,240] have reported decreased lung compliance in hyperthyroidism. The mechanisms are unclear [233,239].…”

Section: Respiratory Mechanicsmentioning

confidence: 99%

“…The mechanisms are unclear [233,239]. Decreased lung compliance [233,239] and muscle strength [210,[229][230][231] probably contribute to the mild reduction in vital capacity seen in some patients [210,229,230,233,[239][240][241][242].…”

Section: Respiratory Mechanicsmentioning

confidence: 99%

“…Hyperthyroid patients are at increased risk for respiratory failure [246] because of decreased respiratory muscle performance [210], decreased lung compliance [233,239], increased ventilatory requirements [241], increased peripheral and central chemoreceptor sensitivity [231], increased respiratory effective impedance [231], and impaired cardiovascular performance [247].…”

Section: Respiratory Failurementioning

confidence: 99%

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Endocrinological derangements in COPD

Laghi

Adıgüzel²,

Tobin³

2009

Eur Respir J

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Chronic obstructive pulmonary disease (COPD) is no longer considered to affect only the lungs and airways but also the rest of the body. The systemic manifestations of COPD include a number of endocrine disorders, such as those involving the pituitary, the thyroid, the gonads, the adrenals and the pancreas.The mechanisms by which COPD alters endocrine function are incompletely understood but likely involve hypoxaemia, hypercapnia, systemic inflammation and glucocorticoid administration. Altered endocrine function can worsen the clinical manifestations of COPD through several mechanisms, including decreased protein anabolism, increased protein catabolism, nonenzymatic glycosylation and activation of the rennin-angiotensin-aldosterone system.Systemic effects of endocrine disorders include abnormalities in control of breathing, decreases in respiratory and limb-muscle mass and function, worsening of respiratory mechanics, impairment of cardiac function and disorders of fluid balance.Research on endocrine manifestations of COPD embraces techniques of molecular biology, integrative physiology and controlled clinical trials. A sound understanding of the various disorders of endocrine function associated with COPD is prudent for every physician who practices pulmonary medicine.

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“…Some [233,239] but not all investigators [229,240] have reported decreased lung compliance in hyperthyroidism. The mechanisms are unclear [233,239].…”

Section: Respiratory Mechanicsmentioning

confidence: 99%

Section: Respiratory Mechanicsmentioning

confidence: 99%

Section: Respiratory Failurementioning

confidence: 99%

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Endocrinological derangements in COPD

Laghi

Adıgüzel²,

Tobin³

2009

Eur Respir J

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“…Although VC has been found to be reduced by about 80% in thyrotoxicosis, 61 this finding has not been conclusively linked to respiratory muscle weakness. 62 VC returns to normal with treatment. Thyrotoxic periodic paralysis, sometimes associ ated with hypokalemia, is uncommonly associated with respiratory muscle weakness.…”

Section: Thyroid Diseasementioning

confidence: 92%

Respiratory Muscle Function in Systemic Disorders

Baydur¹

1988

Semin Respir Crit Care Med

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“…One of three patients with myxoedema studied by Freedman (1978) had significantly increased VC after treatment, and this was attributed to increased inspiratory muscle force. Nicol and Bruce (1981) have demonstrated that elevation of plasma tri-iodothyronine (T3) levels are associated with a progressive alteration from slow-twitch to fast-twitch oxidative glycolytic type muscle fibres.…”

Section: Introductionmentioning

confidence: 94%

Cyclic Adenosine 3′,5′‐monophosphate Content and Bronchial Smooth Muscle Contractility of Hyper‐ and Hypothyroid Lungs

Nabishah

Morat

Alias

et al. 1992

Clin Exp Pharma Physio

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1. Male Sprague-Dawley rats were made either hyper- or hypothyroid with thyroxine or 4-methyl-2-thiouracil, respectively. Bronchial smooth muscle (BSM) contractility and lung cyclic adenosine 3',5'-monophosphate (cAMP) content were measured in both conditions. 2. Bronchial smooth muscle contractility was significantly weaker in hyperthyroid rats, while the BSM contractility of hypothyroid rats was the same as controls. 3. The cAMP content of hyperthyroid rat lungs was similar to controls but was decreased in hypothyroid rats. 4. These studies demonstrated that both the hyper- and hypothyroid states affect respiration, although the mechanisms involved with different for each condition.

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Lung volumes and distensibility, and maximum respiratory pressures in thyroid disease before and after treatment.

Cited by 24 publications

References 15 publications

Endocrinological derangements in COPD

Endocrinological derangements in COPD

Respiratory Muscle Function in Systemic Disorders

Cyclic Adenosine 3′,5′‐monophosphate Content and Bronchial Smooth Muscle Contractility of Hyper‐ and Hypothyroid Lungs

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