Lungenkreislauf und contractile Funktion des rechten Ventrikels bei chronischem Cor Pulmonale: Vergleichende Untersuchungen �ber den Einflu� von Aminophyllin und Heptaminol

Plasma Level-Dependent Hemodynamic Effects of Theophylline in Patients with Chronic Obstructive Lung Disease and Pulmonary Hypertension

“…Thus, our data show, as do those of others, 8,9,11,12 that theophylline reduces pulmonary hypertension without affecting pulmonary capillary wedge pressures. The decrease in PAP was dose dependent and much more pronounced in the group of patients that also responded to oxygen.…”

“…[1][2][3][4] After laboratory techniques for plasma drug level determination became available, theophylline levels between 8 and 20 mg/liter have been re garded as therapeutically effective. [5][6][7] Whereas the cardiovascular effects of theophylline have repeat edly been analyzed, [8][9] there are few investigations that correlate the hemodynamic effects and plasma levels. 2,4,10 Moreover, these investigations were conducted using healthy volunteers and noninva sive methods.…”