Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats

Preetha, S.; Kanniappan, M.; Selvakumar, E.; Nagaraj, M.; Varalakshmi, P.

doi:10.1016/j.cbpc.2006.03.008

Cited by 93 publications

(72 citation statements)

References 39 publications

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“…The reduced activity of GST observed by DMBA administration may be partly due to the lack of its substrate (GSH) [50], which occurs also due to reduced activity of GR. Our results nicely support the data from another report in which pretreatment of lupeol for a week caused reversion of aflatoxin induced peroxidative hepatic damage [51].…”

Section: Discussionsupporting

confidence: 92%

Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice

Prasad

Kalra

Shukla³

2007

Molecular Nutrition Food Res

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Lupeol, a triterpene present in mango and other fruits, is known to exhibit a number of pharmacological properties including antioxidant, antilithiatic, and antidiabetic effects. In the present study, chemopreventive properties of lupeol and mango pulp extract (MPE) were evaluated against 7,12-dimethylbenz(a)anthracene (DMBA) induced alteration in liver of Swiss albino mice. Lupeol (25 mg/kg body weight, bw) or 1 mL of 20% w/v aqueous MPE/mouse were daily given once for 1 wk after a single dose of DMBA (50 mg/kg bw). Lupeol/MPE supplementation effectively influenced the DMBA induced oxidative stress, characterized by restored antioxidant enzyme activities and decrease in lipid peroxidation. A reduction of apoptotic cell population in the hypodiploid region was observed in lupeol and MPE supplemented animals. The inhibition of apoptosis was preceded by decrease in reactive oxygen species (ROS) level and restoration of mitochondrial transmembrane potential followed by decreased DNA fragmentation. In DMBA treated animals, downregulation of antiapoptotic Bcl-2 and upregulation of proapoptotic Bax and Caspase 3 in mouse liver was observed. These alterations were restored by lupeol/MPE, indicating inhibition of apoptosis. Thus, lupeol/MPE was found to be effective in combating oxidative stress induced cellular injury of mouse liver by modulating cell-growth regulators.

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Section: Discussionsupporting

confidence: 92%

Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice

Prasad

Kalra

Shukla³

2007

Molecular Nutrition Food Res

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“…According to the literature, lupeol presents anti-inflammatory, anti-arthritis, antimutagenic, antioxidative, and anticarcinogenic properties, 30 as well as hepatoprotective properties against degenerative lesions caused by AFL. 31 Phytochemical studies of the MeOH extract demonstrated the presence of (ϩ)-catechin, quercetin-3-O-␣-L-arabinopyranoside, quercetin, gallic acid, methyl gallate, and the amentoflavone. In previous studies by our group, using another species of Byrsonima, no mutagenic activity was observed for (ϩ)-catechin, quercetin-3-O-␣-L-arabinopyranoside, and methyl gallate; however, amentoflavone was positive for mutagenic activity.…”

Section: Discussionmentioning

confidence: 99%

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Lira

Santos

Sannomiya

et al. 2008

Journal of Medicinal Food

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Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian "cerrado" (tropical American savanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceae family, and it is commonly known as "murici." Considering the popular use of B. basiloba derivatives and the lack of pharmacological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) and chloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella typhimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and indirect mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B 1 , benzo[a]pyrene, and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level (89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B 1 . Phytochemical analysis of the extracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (ϩ)-catechin, quercetin-3-O-␣-L-arabinopyranoside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2Љ-O-galloyl)-␤-D-galactopyranoside, and quercetin-3-O-(2Љ-O-galloyl)-␣-L-arabinopyranoside.

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“…Further, the changes in the level of serum cholesterol in drug treated groups confirm the organ protective efficacy of lupeol as the changes in the level of serum cholesterol being an indirect indicator of liver function. Lupeol does not exhibit any antinociceptive and ulcerogenic actions in arthritic animals, suggesting that the mechanism of action of lupeol is different from the non steroidal anti-inflammatory drugs (Preetha et al 2006;Bani et al 2006) In conclusion, the present study provides the scientific rationale for the use of C. gigantea latex in the traditional medicine for the treatment of inflammation. Further, it also established the beneficial effects of oral administration of lupeol, an active ingredient in the rubber free fraction of C. gigantea latex against the primary complications such as oedema, pain as well as the secondary complications such as CVD and diabetes.…”

Section: Discussionmentioning

confidence: 91%

Lupeol, a triterpenoid isolated from Calotropis gigantea latex ameliorates the primary and secondary complications of FCA induced adjuvant disease in experimental rats

Venkatesan

Subramanian

2011

Inflammopharmacol

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that affects 1% of the adult population worldwide. Calotropis gigantea is a xerophytic, latex producing medicinal plant widely distributed in nature. Different parts of the plant have been traditionally used for the treatment of various ailments including arthritis. In the present study, we have isolated and characterized lupeol, a pentacyclic triterpene from the dialyzable fraction of the latex and evaluated the anti-arthritic properties of lupeol in Freund's Complete Adjuvant (FCA) induced arthritis in rats. Lupeol (50 mg/kg b.w/day) was administered orally to AA rats for 4 weeks. The alterations in body weight gain, paw volume, RBC, WBC, Hb, EPO, ESR, platelets and PCV were recorded. The activities of serum AST, ALT and ALP were also assayed. The levels of lipid profile were estimated. The levels of pro-inflammatory cytokines as well as anti-inflammatory cytokines such as TNF-α, IL-1β, IL-6 and IL-10 were also analyzed. The results of present study indicate the anti-inflammatory and anti-arthritic activity of lupeol present in the C. gigantea latex.

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Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats

Cited by 93 publications

References 39 publications

Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice

Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Lupeol, a triterpenoid isolated from Calotropis gigantea latex ameliorates the primary and secondary complications of FCA induced adjuvant disease in experimental rats

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