Lupus Hepatitis and Autoimmune Hepatitis (Lupoid Hepatitis)

Adiga, Avinash; Nugent, Kenneth

doi:10.1016/j.amjms.2016.10.014

Cited by 54 publications

(60 citation statements)

References 39 publications

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“…Their histology is characteristic and quite different when compared to pancreatic involvement in SLE or Sjögren's syndrome. This fact is very similar to the case of the liver, hepatitis associated with lupus and autoimmune hepatitis being also the two distinct diseases [10].…”

Section: Introductionsupporting

confidence: 76%

Autoimmune Pancreatitis: Clinical Presentation and Therapy

Fleiszig¹,

Asencio²

2019

Chronic Autoimmune Epithelitis - Sjogren's Syndrome and Other Autoimmune Diseases of the Exocrine Glands

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Autoimmune pancreatitis is a relatively recently identified entity. The dominant type 1 is the pancreatic manifestation of a systemic IgG4-related fibroinflammatory disease. The type 2 has a clearly different histology, its dominant feature is a granulocytic epithelial lesion, and it is independent of IgG4. While type 1 is rather a disease with male dominance in majors than 50-year-old people, no gender difference is observed in type 2, and the disease is more frequently seen in young people. The more frequent initial clinical manifestation is obstructive jaundice in type 1, while abdominal pain and mild acute pancreatitis in type 2. CT and magnetic resonance images are very similar, IgG4 can be normal even in type 1, and the associated involvement of other organs is frequently posterior to the pancreatic manifestation; thus, the distinction of the two types of AIP can be difficult without histology in the everyday clinical practice. Several cases can be undetermined and qualified as Not Otherwise Specified (NOS). However, all types of AIP respond quickly to steroid treatment with a complete recovery. Late prognosis is good, but up to 50% recurrence has been observed in type 1, and several authors have described progression to chronic pancreatitis.

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Section: Introductionsupporting

confidence: 76%

Autoimmune Pancreatitis: Clinical Presentation and Therapy

Fleiszig¹,

Asencio²

2019

Chronic Autoimmune Epithelitis - Sjogren's Syndrome and Other Autoimmune Diseases of the Exocrine Glands

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“…Liver involvement in SLE disease is observed in the literature [21][22][23][24]. While some researchers claim that clinical liver dysfunction is not common in SLE [21,25], others say that it is frequent [22,26]. Regardless of this, the fact is that from 9.8 (in juvenile patients [27]) to 59.7% of patients with this disease may have abnormalities in liver functioning in their lifes [21][22][23]25].…”

Section: Discussionmentioning

confidence: 99%

The Role of MECP2 and CCR5 Polymorphisms on the Development and Course of Systemic Lupus Erythematosus

et al. 2020

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Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease. SLE is described by production of autoantibodies and causes damage of many organs. T-cells play a crucial role in SLE pathogenesis. T-cells intensify inflammation through a number of processes, which leads to autoimmunization. CCR5 and MECP2 genes are linked with T-cells and pathogenesis of SLE. Polymorphisms in these genes are related with the prognostic factors of risk of disease onset and disease severity. The aim of this study was to estimate the influence of polymorphisms in MECP2 and CCR5 genes on the development and course of systemic lupus erythematosus. We examined 137 SLE patients and 604 healthy controls. We studied polymorphisms for CCR5 gene: rs333 and for MECP2: rs2075596, rs1734787, rs17435, and rs2239464. We genotyped our MECP2 samples and we performed a restriction fragment length polymorphism (RFLP) analysis for CCR5 samples. We showed a risk factor for allele T in rs17435 and for allele A in rs2075596 in MECP2. We noticed that MECP2 rs2075596 G/A, rs1734787 C/A, rs17435 A/T, and rs2239464 G/A polymorphisms are more prevalent in SLE patients than in healthy controls. We believe that above-mentioned MECP2 polymorphisms can be considered as SLE susceptibility factor.

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“…Given that workup revealed abnormalities in the autoimmune profile, systemic lupus erythematosus (SLE), a rare cause of EM, was considered. Liver involvement is an underappreciated manifestation of SLE but occurs in up to 50%‐60% of patients . Liver disease can present as AIH or a distinct form of hepatitis related to the connective tissue disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Liver involvement is an underappreciated manifestation of SLE but occurs in up to 50%-60% of patients. (1) Liver disease can present as AIH or a distinct form of hepatitis related to the connective tissue disorder. Both entities are associated with polyarthralgias, hypergammaglobulinemia, and positive ANAs; and differentiation between the two is difficult.…”

Section: Discussionmentioning

confidence: 99%