Lupus vulgar: caso infrecuente de tuberculosis extrapulmonar

M, Carmen Varas; S, Constanza Nieme; M, Carlos Barría

doi:10.4067/s0034-98872012000400010

Cited by 4 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This paper addresses the biomechanical loading in these cases, where stresses in the brain results from blast wavehead interactions. Currently, this is achieved through animal models [16,19], post mortem human subjects (PMHS) [20], head surrogates [21][22][23] and in vitro injury models of single cells to 3D cultures [24,25]. Animal and PMHS studies are costly, time consuming and limited to certain lower order animals due to ethical reasons [16,26].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, models can be designed and tested to validate specific hypothesis. An egg shaped skull/brain surrogate model was developed for the study of head response at different orientations during blast loading [21]; spherical surrogate was developed for the study of effects of skull opening for bTBI [22]. In this study, head (skull-brain complex) is idealized as a fluid filled circular cylinder with the longitudinal axis normal to the blast wave propagation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Blast Wave Loading Pathways in Heterogeneous Material Systems–Experimental and Numerical Approaches

Selvan¹,

Ganpule²,

Kleinschmit³

et al. 2013

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

Blast waves generated in the field explosions impinge on the head-brain complex and induce mechanical pressure pulses in the brain resulting in traumatic brain injury. Severity of the brain injury (mild to moderate to severe) is dependent upon the magnitude and duration of the pressure pulse, which in turn depends on the intensity and duration of the oncoming blast wave. A fluid-filled cylinder is idealized to represent the head-brain complex in its simplest form; the cylinder is experimentally subjected to an air blast of Friedlander type, and the temporal variations of cylinder surface pressures and strains and fluid pressures are measured. Based on these measured data and results from computational simulations, the mechanical loading pathways from the external blast to the pressure field in the fluid are identified; it is hypothesized that the net loading at a given material point in the fluid comprises direct transmissive loads and deflection-induced indirect loads. Parametric studies show that the acoustic impedance mismatches between the cylinder and the contained fluid as well as the flexural rigidity of the cylinder determine the shape/intensity of pressure pulses in the fluid.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blast Wave Loading Pathways in Heterogeneous Material Systems–Experimental and Numerical Approaches

Selvan¹,

Ganpule²,

Kleinschmit³

et al. 2013

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

show abstract

“…Multiple lesions may appear simultaneously, after a temporary immunosuppression ( Figures 1B , 1C and 1D ). 2 , 5 , 59 , 68 , 69 , 70 …”

Section: Lupus Vulgaris or Tuberculosis Lupusmentioning

confidence: 99%

Update on cutaneous tuberculosis

Dias¹,

Filho²,

Quaresma³

et al. 2014

An. Bras. Dermatol.

View full text Add to dashboard Cite

Tuberculosis continues to draw special attention from health care professionals and society in general. Cutaneous tuberculosis is an infection caused by M. tuberculosis complex, M. bovis and bacillus Calmette-Guérin. Depending on individual immunity, environmental factors and the type of inoculum, it may present varied clinical and evolutionary aspects. Patients with HIV and those using immunobiological drugs are more prone to infection, which is a great concern in centers where the disease is considered endemic. This paper aims to review the current situation of cutaneous tuberculosis in light of this new scenario, highlighting the emergence of new and more specific methods of diagnosis, and the molecular and cellular mechanisms that regulate the parasite-host interaction.

show abstract

“…This situation is particularly reflected in HIV and acquired immune deficiency syndrome (AIDS) patients, in whom prevalence of TBC is significantly higher than in the general population [ 17 ]. Cases of extrapulmonary TBC are usually more difficult to diagnose [ 18 ]. This is particularly relevant in paucibacillary forms of cutaneous TBC, where tests for bacillus may be negative.…”

Section: Discussionmentioning

confidence: 99%

Lewandowsky’s Rosaceiform Eruption: a Form of Cutaneous Tuberculosis Confirmed by PCR in Two Patients

Conlledo

Guglielmetti

Sobarzo

et al. 2014

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

IntroductionCutaneous tuberculosis (TBC) is a chronic disease caused by Mycobacterium tuberculosis, and is present in less than 1–2% of all TBC cases. The current problem with diagnosis is the demonstration of bacillus in the skin, especially paucibacillar forms, where sources like polymerase chain reaction (PCR) have improved diagnostic capacity.Case PresentationTwo cases of cutaneous TBC are reported. The first patient was 52-year-old woman with facial erythematous papulo-nodular lesions which had been developing for 4 months, and had previously been treated as acne rosacea, with partial response. Histopathological studies showed chronic granulomatous inflammation. TBC was suspected, so PCR was performed, which showed positive for M. tuberculosis. The second case was a 43-year-old woman with a facial rosaceiform plaque which began 6 months previously, and was treated as rosacea without any change for 5 months. Skin biopsy and PCR were positive for TBC. Both cases were treated using primary schedule for TBC, and both presented a favorable response.DiscussionA clinical profile called Lewandowsky’s rosacea-like eruption has been previously described. The condition has been questioned for years and was later removed from the spectrum of tuberculids and cutaneous TBC for not being able to isolate microorganisms in skin samples, a situation that might now change. In paucibacillar forms, when culture and staining are negative and TBC is still suspected, it is recommended to use DNA amplification by PCR for an accurate diagnosis. Both cases bring up the concern about once again bringing Lewandowsky’s rosaceiform eruption into the spectrum of cutaneous TBC, and the discussion about the current definition of tuberculid.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-014-0066-x) contains supplementary material, which is available to authorized users.

show abstract

Lupus vulgar: caso infrecuente de tuberculosis extrapulmonar

Cited by 4 publications

References 21 publications

Blast Wave Loading Pathways in Heterogeneous Material Systems–Experimental and Numerical Approaches

Blast Wave Loading Pathways in Heterogeneous Material Systems–Experimental and Numerical Approaches

Update on cutaneous tuberculosis

Lewandowsky’s Rosaceiform Eruption: a Form of Cutaneous Tuberculosis Confirmed by PCR in Two Patients

Contact Info

Product

Resources

About