Lutein protected the retina from light induced retinal damage by inhibiting increasing oxidative stress and inflammation

Jiao, Yang; Li, Dankang; Zhang, Yaqin; Zhang, Li; Liao, Zhangyi; Aihemaitijiang, Sumiya; Hou, Yanmei; Zhan, Zhijun; Xie, Kui; Zhang, Zhaofeng

doi:10.1016/j.jff.2020.104107

Cited by 25 publications

(15 citation statements)

References 38 publications

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“…Food supplements or dietary interventions including antioxidant compounds are used frequently to prevent retinal diseases [ 6 ]. In experimental models of light induced retinal damage, there is indication that diet and dietary supplements with lutein and C3G can be beneficially used against light-associated oxidative stress and inflammatory processes [ 4 , 31 ]. In patients, dietary administration of antioxidants has been shown to reduce the incidence of oxidative stress-related eye diseases [ 32 ], although several studies provided conflicting results [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

et al. 2021

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Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The use of natural antioxidants has emerged as promising approach for the prevention of LD. Among them, lutein and cyanidin-3-glucoside (C3G) have been shown to be particularly effective due to their antioxidant and anti-inflammatory activity. However, less is known about the possible efficacy of combining them in a multicomponent mixture. In a rat model of LD, Western blot analysis, immunohistochemistry and electroretinography were used to demonstrate that lutein and C3G in combination or in a multicomponent mixture can prevent oxidative stress, inflammation, gliotic and apoptotic responses thus protecting photoreceptor cells from death with higher efficacy than each component alone. Combined efficacy on dysfunctional electroretinogram was also demonstrated by ameliorated rod and cone photoreceptor responses. These findings suggest the rationale to formulate multicomponent blends which may optimize the partnering compounds bioactivity and bioavailability.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

et al. 2021

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“…Lut has been shown to be protective against oxidative stress for eye health in different cell models such as in human lens epithelial cells [ 52 ] and retinal ganglion cells [ 53 ]. As mentioned previously, Lut also protects against oxidative-induced RPE dysfunction and cell death [ 28 , 54 , 55 ]. Therefore, it was hypothesized that the prodrug of Lut, Lut-DG, would exert a similar effect against oxidative stress.…”

Section: Discussionmentioning

confidence: 81%

Protective Effects of a Lutein Ester Prodrug, Lutein Diglutaric Acid, against H2O2-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells

Muangnoi

Phumsuay

Jongjitphisut

et al. 2021

IJMS

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Oxidative stress-induced cell damage and death of the retinal pigmented epithelium (RPE), a polarized monolayer that maintains retinal health and homeostasis, lead to the development of age-related macular degeneration (AMD). Several studies show that the naturally occurring antioxidant Lutein (Lut) can protect RPE cells from oxidative stress. However, the poor solubility and low oral bioavailability limit the potential of Lut as a therapeutic agent. In this study, lutein diglutaric acid (Lut-DG), a prodrug of Lut, was synthesized and its ability to protect human ARPE-19 cells from oxidative stress was tested compared to Lut. Both Lut and Lut-DG significantly decreased H2O2-induced reactive oxygen species (ROS) production and protected RPE cells from oxidative stress-induced death. Moreover, the immunoblotting analysis indicated that both drugs exerted their protective effects by modulating phosphorylated MAPKs (p38, ERK1/2 and SAPK/JNK) and downstream molecules Bax, Bcl-2 and Cytochrome c. In addition, the enzymatic antioxidants glutathione peroxidase (GPx) and catalase (CAT) and non-enzymatic antioxidant glutathione (GSH) were enhanced in cells treated with Lut and Lut-DG. In all cases, Lut-DG was more effective than its parent drug against oxidative stress-induced damage to RPE cells. These findings highlight Lut-DG as a more potent compound than Lut with the protective effects against oxidative stress in RPE cells through the modulation of key MAPKs, apoptotic and antioxidant molecular pathways.

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“…Previous studies have evaluated the therapeutic effect in vivo of different molecules by inducing retinal degeneration with chronic light stress under blue light. For example, lutein orally administered at 25 mg/kg/day with corn oil demonstrated its efficacy for protecting photoreceptors for 30 days, with 1.5 h/day (1500 Lux) of light exposure after pretreatment on rats [ 57 ]. In another study, the authors administered Cistanche Tubulosa orally to rats at a rate of 100 mg/kg/day for 74 days, induced degeneration with blue light (150 Lux) 3 h/day during the last 60 days, and demonstrated the protective effect of Cistanche Tubulosa in vivo [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

Formulation and Evaluation of SNEDDS Loaded with Original Lipophenol for the Oral Route to Prevent Dry AMD and Stragardt’s Disease

et al. 2022

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Dry age-related macular degeneration (Dry AMD) and Stargardt’s disease (STGD1) are common eye diseases, characterized by oxidative and carbonyl stress (COS)-inducing photoreceptor degeneration and vision loss. Previous studies have demonstrated the protective effect of photoreceptors after the intravenous administration of a new lipophenol drug, phloroglucinol-isopropyl-DHA (IP-DHA). In this study, we developed an oral formulation of IP-DHA (BCS Class IV) relying on a self-nanoemulsifying drug delivery system (SNEDDS). SNEDDS, composed of Phosal® 53 MCT, Labrasol®, and Transcutol HP® at a ratio of 25/60/15 (w/w/w), led to a homogeneous nanoemulsion (NE) with a mean size of 53.5 ± 4.5 nm. The loading of IP-DHA in SNEDDS (SNEDDS-IP-DHA) was successful, with a percentage of IP-DHA of 99.7% in nanoemulsions. The in vivo study of the therapeutic potency of SNEDDS-IP-DHA after oral administration on mice demonstrated photoreceptor protection after the induction of retinal degeneration with acute light stress (73–80%) or chronic light stress (52–69%). Thus, SNEDDS formulation proved to increase the solubility of IP-DHA, improving its stability in intestinal media and allowing its passage through the intestinal barrier after oral force-fed administration, while maintaining its biological activity. Therefore, SNEDDS-IP-DHA is a promising future preventive treatment for dry AMD and STGD1.

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Lutein protected the retina from light induced retinal damage by inhibiting increasing oxidative stress and inflammation

Cited by 25 publications

References 38 publications

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

Protective Effects of a Lutein Ester Prodrug, Lutein Diglutaric Acid, against H2O2-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells

Formulation and Evaluation of SNEDDS Loaded with Original Lipophenol for the Oral Route to Prevent Dry AMD and Stragardt’s Disease

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