Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density

Ma, Le; Liu, Rong; Du, Junhui; Liu, Tao; Wu, Shan; Liu, Xiao Hong

doi:10.3390/nu8070426

Cited by 98 publications

(83 citation statements)

References 62 publications

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“…It should be noted that tuna fish, especially tinned tuna, is an important source of meso-zeaxanthin. Meso-zeaxanthin supplementation has been shown to improve macular pigment optical density in both AMD patients and healthy subjects in a dose-response relationship [43]. In the Meso-zeaxanthin Ocular Supplementation Trial (MOST), it was found that a significant increase in macular pigment from baseline was observed in the meso-zeaxanthin treated group [44].…”

Section: Discussionmentioning

confidence: 99%

Fish Consumption and Age-Related Macular Degeneration Incidence: A Meta-Analysis and Systematic Review of Prospective Cohort Studies

Zhu

et al. 2016

Nutrients

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The association between fish consumption and risk of age-related macular degeneration (AMD) is still unclear. The aim of the current meta-analysis and systematic review was to quantitatively evaluate findings from observational studies on fish consumption and the risk of AMD. Relevant studies were identified by searching electronic databases (Medline and EMBASE) and reviewing the reference lists of relevant articles up to August, 2016. Prospective cohort studies that reported relative risks (RRs) and 95% confidence intervals (CIs) for the link between fish consumption and risk of AMD were included. A total of 4202 cases with 128,988 individuals from eight cohort studies were identified in the current meta-analysis. The meta-analyzed RR was 0.76 (95% CI, 0.65–0.90) when any AMD was considered. Subgroup analyses by AMD stages showed that fish consumption would reduce the risk of both early (RR, 0.83; 95% CI, 0.72–0.96) and late (RR; 0.76; 95% CI, 0.60–0.97) AMD. When stratified by the follow-up duration, fish consumption was a protective factor of AMD in both over 10 years (n = 5; RR, 0.81; 95% CI, 0.67–0.97) and less than 10 years (n = 3; RR, 0.70; 95% CI, 0.51 to 0.97) follow-up duration. Stratified analyses by fish type demonstrated that dark meat fish (RR, 0.68, 95% CI, 0.46–0.99), especially tuna fish (RR, 0.58; 95% CI, 95% CI, 0.47–0.71) intake was associated with reduced AMD risk. Evidence of a linear association between dose of fish consumption and risk of AMD was demonstrated. The results of this meta-analysis demonstrated that fish consumption can reduce AMD risk. Advanced, well-designed, randomized clinical trials are required in order to validate the conclusions in this study.

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Section: Discussionmentioning

confidence: 99%

Fish Consumption and Age-Related Macular Degeneration Incidence: A Meta-Analysis and Systematic Review of Prospective Cohort Studies

Zhu

et al. 2016

Nutrients

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“…There is increasing evidence that MP levels in the retina can be augmented through increased intake of dietary L and Z in healthy and diseased retinas, suggesting the possibility that therapeutic intervention in the form of dietary modification or nutritional supplementation may modulate the risk of diseases associated with a relative lack of MP 49 50. Furthermore, inclusion of MZ in the carotenoid supplementation results in greater increase in MP compared with supplements lacking this central carotenoid 51 52…”

Section: Lutein and Zeaxanthinmentioning

confidence: 99%

Putative protective role of lutein and zeaxanthin in diabetic retinopathy

et al. 2017

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Diabetic retinopathy (DR) is one of the most important microvascular complications of diabetes and remains the leading cause of blindness in the working-age individuals. The exact aetiopathogenesis of DR remains elusive despite major advances in basic science and clinical research. Oxidative damage as one of the underlying causes for DR is increasingly being recognised. In humans, three hydroxycarotenoids, lutein (L), zeaxanthin (Z) and -zeaxanthin (MZ), accumulate at the central retina (to the exclusion of all other dietary carotenoids), where they are collectively known as macular pigment. These hydroxycarotenoids by nature of their biochemical structure and function help neutralise reactive oxygen species, and thereby, prevent oxidative damage to the retina (biological antioxidants). Apart from their key antioxidant function, evidence is emerging that these carotenoids may also exhibit neuroprotective and anti-inflammatory function in the retina. Since the preliminary identification of hydroxycarotenoid in the human macula by Wald in the 1940s, there has been astounding progress in our knowledge of the role of these carotenoids in promoting ocular health. While the Age-Related Eye Disease Study 2 has established a clinical benefit for L and Z supplements in patients with age-related macular degeneration, the role of these carotenoids in other retinal diseases potentially linked to oxidative damage remains unclear. In this article, we comprehensively review the literature germane to the putative protective role of two hydroxycarotenoids, L and Z, in the pathogenesis of DR.

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“…Lutein and zeaxanthin are xanthophyll carotenoids that are concentrated in the macula and are known for their roles in antioxidation [19][20][21]. One systemic review with meta-analysis of twenty randomized controlled trials (RCTs) revealed a proportional increase of macular pigment optical density with lutein and zeaxanthin supplementation [22], indicating beneficial efficacy of supplemented lutein and zeaxanthin intake in improving ocular health. Accumulating evidence has shown that black currant (Ribes nigrum L.) is beneficial for visual functions potentially by increasing ocular blood flows to mitigate eye fatigue symptoms [23,24].…”

Section: Introductionmentioning

confidence: 99%

A Novel Botanical Combination Attenuates Light-Induced Retinal Damage through Antioxidant and Prosurvival Mechanisms

Kan¹,

Cheng

Guo³

et al. 2020

Oxidative Medicine and Cellular Longevity

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The prevalence of light-induced eye fatigue is increasing globally. Efficient regimen for mitigating light-induced retinal damage is becoming a compelling need for modern society. We investigated the effects of a novel combination of lutein ester, zeaxanthin, chrysanthemum, goji berry, and black currant extracts against retinal damage. In the current work, both in vitro and in vivo light-induced retinal damage models were employed. Animal study showed that under strong light exposure (15000 lx for 2 hours), the a-wave and b-wave from electroretinogram were significantly decreased. Treatment with the combination significantly restored the decrease for b-wave under high-and low-stimulus intensity. Histological analysis reported a substantial decrease in the outer nuclear layer (ONL) thickness in the model group, while the supplementation with the combination significantly improved the ONL thickness. To further explore the underlying mechanism of the protective effects, we utilized ARPE-19 retinal pigment epithelial cell line and found that strong light stimulation (2900 lx for 30 minutes) significantly increased phosphorylation of p38 and JNK and decreased HIF expression. Intriguingly, chrysanthemum, black currant extracts, lutein ester, and zeaxanthin significantly decreased the phosphorylation of p38 and JNK, while chrysanthemum, goji berry, black currant extracts, and lutein ester restored HIF expression. The botanical combination can alleviate light-induced retina damage, potentially through antioxidant and prosurvival mechanisms.

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Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density

Cited by 98 publications

References 62 publications

Fish Consumption and Age-Related Macular Degeneration Incidence: A Meta-Analysis and Systematic Review of Prospective Cohort Studies

Fish Consumption and Age-Related Macular Degeneration Incidence: A Meta-Analysis and Systematic Review of Prospective Cohort Studies

Putative protective role of lutein and zeaxanthin in diabetic retinopathy

A Novel Botanical Combination Attenuates Light-Induced Retinal Damage through Antioxidant and Prosurvival Mechanisms

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