Luteinized unruptured follicle syndrome: incidence and recurrence rate in infertile women with unexplained infertility undergoing intrauterine insemination

Qublan, Hussein S.; Amarin, Zouhair; Nawasreh, M.; Diab, F. M.; Malkawi, S.; Al-Ahmad, N.; Balawneh, M.

doi:10.1093/humrep/del113

Cited by 90 publications

(64 citation statements)

References 23 publications

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“…In small rodents with a 4-day-estrous cycle, neutrophils are found in the follicle wall (Brännström et al 1994b;Brännström et al, 1994b;Brännström and Enskog, 2002), whereas, in human and bovine follicles in the transition to a CL, the CD18-positive leukocyte pool relate to 90% of eosinophils (Aust et al, 2000;Reibiger and Spanel-Borowski, 2000). Their classical role in parasite infections is here extended to sterile inflammation as (Qublan et al, 2006;Löffler et al, 2004b). Evidence is collected that the tachykinin-tachykinin receptor system is influential as intraovarian modulator in granulosa and luteal cells (Löffler et al, 2004a;Brylla et al, 2005;Debeljuk, 2006).…”

Section: Eosinophils and Tachykinin Expression For Tissue Repair In Imentioning

confidence: 99%

Ovulation as danger signaling event of innate immunity

Spanel‐Borowski

2011

Molecular and Cellular Endocrinology

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Section: Eosinophils and Tachykinin Expression For Tissue Repair In Imentioning

confidence: 99%

Ovulation as danger signaling event of innate immunity

Spanel‐Borowski

2011

Molecular and Cellular Endocrinology

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“…However, the indication is not infallible. A rare disease, luteinized unruptured follicle syndrome, is known to undergo luteinization without ovulation [14]. In addition, progesterone receptor-null mice are able to form corpus luteum containing trapped oocyte [15].…”

Section: Discussionmentioning

confidence: 99%

Ovarian Histological Findings in an Adult Patient with the Steroidogenic Acute Regulatory Protein (StAR) Deficiency Reveal the Impairment of Steroidogenesis by Lipoid Deposition

et al. 2008

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Abstract. Context: The steroidogenic acute regulatory protein (StAR) is essential for the production of steroid hormones. The mutations in the StAR gene typically cause congenital lipoid adrenal hyperplasia (lipoid CAH), characterized by severe adrenal insufficiency in both sexes and complete female external genitalia in genetic males. Affected 46, XX females feminize at puberty and menstruate but have progressive hypergonadotropic hypogonadism. It has been hypothesized that the cholesterol accumulation in the steroidogenic cells destroys the residual steroidogenic capacity and progressive ovarian failure occurs (two-hit model). Additionally, ovulation and luteinization in the patients is supposed to be impaired. However, those hypotheses have not been confirmed histologically. Objective: We examined whether pathological findings of the ovary in a patient of lipoid CAH corresponded with two-hit model, and whether ovulation and luteinization occurred or not in the patient. Subject: The ovary in an adult 46, XX female with a homozygous nonsense mutation (Q258X) in the StAR gene was examined. When the patient was age 22 yr, the ovary was resected because of enlargement with polycysts and subsequent torsion. Result: The affected ovary demonstrated remarkable lipoid deposition and changes of the mitochondrial ultrastructure. Immunohistochemical examination showed decrease of steroidogenic enzymes such as P450 cholesterol side-chain cleavage (P450scc). Additionally, we detected corpus albicans in the affected ovary. Conclusion: This is the first detailed report on ovarian histology in an adult 46, XX female with a null type mutation of the StAR gene (Q258X), which indicates the evidence of the impairment of ovarian StAR-independent steroidogenesis by lipoid deposition.

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“…It is reported to be as high as 25% in unexplained infertile couples undergoing IUI with clomiphene citrate [15]. LUF decreases the chance of pregnancy after intrauterine insemination treatment.…”

Section: Discussionmentioning

confidence: 99%

Intrauterine insemination: is the timing correct?

Küçük¹

2008

J Assist Reprod Genet

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Objective To evaluate the impact of follicle rupture on pregnancy rate in intrauterine insemination. Material and method Retrospective cohort study. Evidence of follicle rupture was assessed by transvaginal ultrasonography following IUI. Two hundred ninety-six couples with unexplained infertility and 121 couples with male factor subfertility were included. Results of 578 cycles were analyzed here. Result Clinical pregnancy rate was 23.5% (64/272) in the group when follicle rupture was evident by transvaginal ultrasonography, while it was only 8.8% (27/306) when follicle rupture was not evident (p<0.001). Conclusion Postponing IUI until observation of follicle rupture may yield a higher pregnancy rate.

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Luteinized unruptured follicle syndrome: incidence and recurrence rate in infertile women with unexplained infertility undergoing intrauterine insemination

Abstract: The incidence and recurrence rate of LUF are significantly increased in subsequent cycles of IUI. In these patients, other options of infertility treatment might be justified.

Cited by 90 publications

References 23 publications

Ovulation as danger signaling event of innate immunity

Ovulation as danger signaling event of innate immunity

Ovarian Histological Findings in an Adult Patient with the Steroidogenic Acute Regulatory Protein (StAR) Deficiency Reveal the Impairment of Steroidogenesis by Lipoid Deposition

Intrauterine insemination: is the timing correct?

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