Luteinizing hormone, growth hormone, insulin-like growth factor-i, insulin and metabolites before puberty in heifers fed to gain at two rates

Yelich, Joel; Wettemann, R. P.; Marston, T.T.; Spicer, L. J.

doi:10.1016/0739-7240(96)00046-x

Cited by 97 publications

(69 citation statements)

References 55 publications

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“…Crosses of British heifers with Nelore breed are expected to be higher due to the greater structure size of Nelore animals in relation to Hereford or Angus (Thallman et al, 1999). In addition, the nutritional level after weaning did affect the frame score size in heifers, as previously demonstrated by Yelich et al, (1996). In agreement, Hall et al (1994) found no differences in height of heifers receiving 14 Mcal day -1 or 10 Mcal day -1 of metabolisable energy.…”

Section: Discussionsupporting

confidence: 76%

Relationship of post-weaning growth and age at puberty in crossbred beef heifers

et al. 2017

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-This study was intended to evaluate body size structure and growth parameters of crossbred heifers fed at four nutritional levels to achieve puberty earlier. Animals were classified depending on their level of crossing between Nelore and Hereford and subjected to four nutritional levels (kg day -1 ) as follows: 0.5 (light; n = 32), 0.75 (medium; n = 32), 1.00 (high; n = 29), and 1.25 (very high; n = 27). Heifers at puberty and at weaning were individually classified for growth parameters. The fat thickness and longissimus muscle area throughout the experimental period were determined by ultrasonography. The height, heart girth, frame, and weight:height ratio were variables used to evaluate body traits. Univariate analysis of variance using the GLIM MIXED procedure os SPSS was performed and the significance level was set at 0.05. Age and body weight at puberty were 388±1.9 days and 331.4±1.3 kg, respectively. Body condition score demonstrated an interaction between nutritional level and crossbred degree. Heifers with the highest degree of Nelore had higher fat thickness and lower weight:height ratio compared with other racial groups at puberty. Pearson correlation coefficient showed a negative association for body condition score (-0.34) and fat thickness (-0.58) compared with age at puberty. The increased fat thickness at younger ages at puberty was observed in all racial groups. The increased weight:height ratio at younger ages at puberty was observed in all racial groups. We observed higher values for a frame in animals at the higher level of supplementation. There is a greater correlation between live weight gain and phenotypic traits during weaning to achieve puberty at an earlier age in crossbred heifers.

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Section: Discussionsupporting

confidence: 76%

Relationship of post-weaning growth and age at puberty in crossbred beef heifers

et al. 2017

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“…In period 2 compared with period 1, plasma glucose and BHB decreased in the restricted group whereas plasma insulin and IGF-I increased and NEFAs decreased in the overfed group. Those results are consistent with those from other studies in growing heifers: decreased plasma glucose, insulin and IGF-I and increased plasma NEFAs are associated with dietary restriction (Yambayamba et al 1996, Chelikani et al 2004; increased glucose, insulin and IGF-I and decreased NEFAs are associated with high energy intake (Burgwald-Balstad et al 1995, Yelich et al 1996, Lalman et al 2000. Increased plasma BHB in the overfed group is probably due to higher feed intake and a ruminal rather than a hepatic origin of BHB (Gutierrez et al 1997).…”

Section: Metabolite and Metabolic Hormone Plasma Concentrationssupporting

confidence: 82%

Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers

Fréret¹,

Grimard²,

Ponter³

et al. 2006

Reproduction

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The aim of our study was to test whether a reduction in dietary intake could improve in vitro embryo production in superovulated overfed dairy heifers. Cumulus-oocyte complexes of 16 Prim' Holstein heifers (14 6 1 months old) were collected by ovum pick-up (OPU), every 2 weeks following superovulation treatment with 250 mg FSH, before being matured and fertilized in vitro. Embryos were cultured in Synthetic Oviduct Fluid medium for 7 days. Heifers were fed with hay, soybean meal, barley, minerals and vitamins. From OPU 1 to 4 (period 1), all heifers received individually for 8 weeks a diet formulated for a 1000 g/day live-weight gain. From OPU 5 to 8 (period 2), the heifers were allocated to one of two diets (1000 or 600 g/day) for 8 weeks. Heifers' growth rates were monitored and plasma concentrations of metabolites, metabolic and reproductive hormones were measured each week. Mean live-weight gain observed during period 1 was 950 6 80 g/day (n 5 16). In period 2 it was 730 6 70 (n 5 8) and 1300 6 70 g/day (n 5 8) for restricted and overfed groups respectively. When comparing period 1 and period 2 within groups, significant differences were found. In the restricted group, a higher blastocyst rate, greater proportions of grade 1-3 and grade 1 embryos, associated with higher estradiol at OPU and lower glucose and b-hydroxybutyrate, were observed in period 2 compared with period 1. Moreover, after 6 weeks of dietary restriction (OPU 7), numbers of day 7 total embryos, blastocysts and grade 1-3 embryos had significantly increased. On the contrary, in the overfed group, we observed more <8 mm follicles 2 days before superovulation treatment, higher insulin and IGF-I and lower nonesterified fatty acids in period 2 compared with period 1 (no significant difference between periods for embryo production). After 6 weeks of 1300 g/day live-weight gain (OPU 7), embryo production began to decrease. Whatever the group, oocyte collection did not differ between period 1 and 2. These data suggest that following a period of overfeeding, a short-term dietary intake restriction (6 weeks in our study) may improve blastocyst production and embryo quality when they are low. However, nutritional recommendations aiming to optimize both follicular growth and embryonic development may be different.

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“…This would have resulted in a change in the ratio between IGFBP-3 and IGF-1, and suggests that variation in IGF-1: IGFBP-3 ratio could possibly mediate the time to reach puberty. Results obtained by Jones et al (1991), Granger et al (1989) and Yelich et al (1996) differ from results obtained in the present experiment in terms of association between puberty and IGF-1 concentration. These authors found that IGF-1 increased before puberty, independent of dietary treatment.…”

Section: Discussioncontrasting

confidence: 57%

“…Several authors (Menge et al, 1960;Short et al, 1971;Yelich et al, 1996) have shown that there is an inverse correlation between the level of intake and age at puberty in heifers. Nutritional status affects circulating concentrations of IGF-1, as discussed above, and this may affect not only growth rate, but other physiological functions.…”

Section: Discussionmentioning

confidence: 99%

The roles of the insulin-like growth factor system and leptin as possible mediators of the effects of nutritional restriction on age at puberty and compensatory growth in dairy heifers

Luna-Pinto¹,

Cronje²

2000

SA J. An. Sci.

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The aim of this experiment was to determine to what extent changes in the blood concentrations of insulinlike growth factor-1 (IGF-1), IGF binding proteins (IGFBPs), leptin and glucose are associated with compensatory growth and age at puberty in Friesian heifers. Twelve heifers (6 months old; 179.8 kg body weight) were allocated to one of two dietary treatments for 30 weeks. Treatments were designed to result in two different growth rates during the first 13 weeks of the experiment, viz. 0.3 kg/d (restriction treatment) or 0.6 kg/d (control treatment). From week 14 to 30, the restricted group received the same amount of feed per kg bodyweight as was fed to the control group (compensatory phase). Heifers in the control treatment reached puberty four weeks earlier than the restricted group. Mean body weight at puberty was 256.3 kg and was not affected by treatment. During the compensatory phase, the growth rate of the previously restricted animals was greater, and feed conversion ratio superior, compared to that of the control group. Plasma IGF-1 and IGFBP-3 concentrations were higher in the restricted group than in the control group during the early compensatory phase. Concentrations of IGFBP-3 increased and peaked at puberty for both treatments, even though puberty occurred at different ages. In contrast, concentrations of IGF-1 peaked at the point of maximum growth rate in the previously restricted animals, and in neither treatment was there a clear relationship with the age of puberty. Plasma leptin concentrations increased until puberty in both treatments even though the date of puberty differed. Plasma glucose concentration did not change at puberty for either treatment; however, differences between treatments were found after the restriction period. There were no differences in IGFBP-2 concentrations between treatments or sampling periods. It is concluded that concentrations of glucose, IGF-1 and IGFBP-3 are affected by nutritional restriction and repletion, and may contribute in some measure to the endocrine regulation of compensatory growth. It is suggested that the increased concentrations of leptin and IGFBP-3 during pubertal development may act as physiological signals for the onset of puberty.

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Luteinizing hormone, growth hormone, insulin-like growth factor-i, insulin and metabolites before puberty in heifers fed to gain at two rates

Cited by 97 publications

References 55 publications

Relationship of post-weaning growth and age at puberty in crossbred beef heifers

Relationship of post-weaning growth and age at puberty in crossbred beef heifers

Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers

The roles of the insulin-like growth factor system and leptin as possible mediators of the effects of nutritional restriction on age at puberty and compensatory growth in dairy heifers

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