Luteinizing Release Hormone Tests in Impotent Diabetic Males

Wright, Alex; London, David; Holder, G.; Williams, Janith; Rudd, B. T.

doi:10.2337/diab.25.10.975

Cited by 30 publications

(4 citation statements)

References 5 publications

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“…Some patients do in fact later develop other features of autonomic neuropathy and abnormal tests [105,172]. Despite earlier reports [167,168] there is no evidence that endocrine dysfunction contributes and recent studies showed normal plasma gonadotrophins [173,174] and testosterone [175] in diabetics with impotence.…”

Section: Urogenital Systemmentioning

confidence: 99%

Diabetic autonomic neuropathy

1979

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This review attempts to outline the present understanding of diabetic autonomic neuropathy. The clinical features have been increasinly recognised but knowledge of the localization and morphology of the lesions and their pathogenesis remains fragmentary. A metabolic causation as postulated in somatic nerves accords best with clinical observations. Most bodily systems, particularly the cardiovascular, gastrointestinal and urogenital, are involved with added disturbances of thermoregulatory function and pupillary reflexes. Possible effects on neuroendocrine and peptidergic secretion and respiratory control await definition. Current interest centres around the development of a new generation of tests of autonomic nerve function that are simple, non-invasive, reproducible and allow precision in diagnosis and accurate quantitation. Most are based on cardiovascular reflexes and abnormality in them is assumed to reflect autonomic damage elsewhere. Probably no single test suffices and a battery of tests reflecting both parasympathetic and sympathetic function is preferable. Little is known of the natural history. The prevalence may be greater than previously suspected and although symptoms are mild in the majority, a few develop florid features. The relation of control and duration of diabetes to the onset and progression of autonomic neuropathy is not clearly established. Once tests of autonomic function become abnormal they usually remain abnormal. Symptomatic autonomic neuropathy carries a greatly increased mortality rate possibly due to indirect mechanisms such as renal failure and direct mechanisms such as cardio-resiratory arrest. Improved treatment of some of the more disabling symptoms has been possible in recent years.

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Section: Urogenital Systemmentioning

confidence: 99%

Diabetic autonomic neuropathy

1979

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“…In experimental, streptazotocin induced, diabetes in rats, plasma T levels were decreased, but it is difficult to exclude a direct effect of streptazotocin. Charrau et al (1978) reported a decreased LH binding capacity of Leydig cells, whereas several groups (Kent 1966;Wright et al 1976) reported normal testosterone levels in male diabeucs; others (Gattucio et al 1978) reported low plasma T and reduced response to hCG whereas Ando et al (1978) reported sex hormone levels in diabetics to be similar to those found in elderly men.…”

Section: E Catecholamines and Neurotransmittersmentioning

confidence: 98%

Effects of drugs on Leydig cell function

Vermeulen

1982

Int J of Andrology

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“…However, there are few and conflicting data assessing pituitary gonadal function in diabetic patients with and without impotence. Rastogi et al (1974) demonstrated normal gonadotropin response to GnRH in diabetic men with and without impotence, while Wright et al (1976) and Shahwan et al (1978) have shown reduced LH response to GnRH in impotent diabetic male patients. Distiller et al (1975), studying male and female diabetic patients, demonstrated reduced LH response to GnRH at 30 minutes in the females and at 30 and 120 minutes in the males.…”

Section: Introductionmentioning

confidence: 99%

Pituitary Gonadal Function in Diabetic Male Patients with and without Impotence

et al. 2009

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This study was undertaken to further assess the integrity of the hypothalamic pituitary axis using a combined GnRH-TRH test in diabetic male patients, with and without impotence. Furthermore, the stimulation test was performed before and after continuous insulin infusion in an attempt to acutely control the hyperglycemia in diabetic patients and to achieve near normal values of plasma glucose during the study. Patients and MethodsStudy Subjects: A group of 9 insulin treated diabetic male patients, age 19-39 years, attending the diabetic outpatient clinic at the Los Angeles County University of Southern California Medical Center participated in the study. The patients were free of intercurrent illness, and were on no medications except insulin. With the exception of patient number 5, who received a combination of semilente and lente insulins, all other patients were on NPH (Neutral Protamine Hagedorn) insulin once a day. There were no clinical features of laboratory evidence of ketosis, and the patients were in stable diabetic control. There was no evidence of other illness, such as eunuchoidism, hypothyroidism, hemochromatosis, liver disease or renal disease. Every patient underwent a complete physical and neurological examination to detect peripheral neuropathy, postural hypotension and peripheral vascular disease. Four of this group of patients had symptoms of sexual dysfunction mani-

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Luteinizing Release Hormone Tests in Impotent Diabetic Males

Cited by 30 publications

References 5 publications

Diabetic autonomic neuropathy

Diabetic autonomic neuropathy

Effects of drugs on Leydig cell function

Pituitary Gonadal Function in Diabetic Male Patients with and without Impotence

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