Effects of drugs on Leydig cell function

Vermeulen, A.

doi:10.1111/j.1365-2605.1982.tb00312.x

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1989

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Visualization of the cytoskeleton in Leydig cells in vitro

Bilińska

1989

Histochemistry

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Effect of LH, vinblastine and cytochalasin B on the cytoskeleton of cultured Leydig cells was investigated using monoclonal antibodies and fluorescence microscopy. After LH addition and treatment with cytoskeletal disrupting drugs, three main effects were observed: 1) increase of androgen level secreted by cultured mouse Leydig cells, 2) changes of cell-shape towards regular and rounded, 3) increase of delta 5,3 beta-HSD activity. The results are discussed in respect to possible involvement of cytoskeleton in the regulation of steroidogenesis.

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