Luteolin alleviates vascular dysfunctions in CLP-induced polymicrobial sepsis in mice

Rungsung, Soya; Singh, Thakur Uttam; Kirthika, Perumalraja; Mahobiya, Archana; Sharma, Meemansha; Lingaraju, Madhu Cholenahalli; Parida, Subhashree; Sahoo, Monalisa; Kumar, Dinesh

doi:10.1007/s43440-022-00399-4

Cited by 4 publications

(3 citation statements)

References 50 publications

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“…The flavonoid rhamnetin decreases organ failure in Gram-negative bacterial sepsis in mice [ 87 ]. Similarly, the flavonoids luteolin and icariin increase survival against polymicrobial sepsis [ 36 , 37 ]. The dietary flavonoid fisetin extracted from berries protects against polymicrobial sepsis-induced inflammatory response and multiple organ dysfunction [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, polyphenolic antioxidant flavonoid consumption improves endotoxemia and septic condition. Several types of flavonoids improve MODS and increase survival against sepsis [ 36 , 37 , 38 ]. The evidence suggests that the nutrient composition of food affects sepsis progression and its outcomes, but the molecular underlying mechanism has not been completely described.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats

et al. 2023

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Sepsis syndrome develops through enhanced secretion of pro-inflammatory cytokines and the generation of reactive oxygen species (ROS). Sepsis syndrome is characterized by vascular hyperpermeability, hypotension, multiple organ dysfunction syndrome (MODS), and increased mortality, among others. Endotoxemia-derived sepsis is an important cause of sepsis syndrome. During endotoxemia, circulating endotoxin interacts with endothelial cells (ECs), inducing detrimental effects on endothelium function. The endotoxin induces the conversion of ECs into fibroblasts, which are characterized by a massive change in the endothelial gene-expression pattern. This downregulates the endothelial markers and upregulates fibrotic proteins, mesenchymal transcription factors, and extracellular matrix proteins, producing endothelial fibrosis. Sepsis progression is modulated by the consumption of specific nutrients, including ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoids. However, the underlying mechanism is poorly described. The notion that gene expression is modulated during inflammatory conditions by nutrient consumption has been reported. However, it is not known whether nutrient consumption modulates the fibrotic endothelial gene-expression pattern during sepsis as a mechanism to decrease vascular hyperpermeability, hypotension, MODS, and mortality. Therefore, the aim of this study was to investigate the impact of the consumption of dietary ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoid supplements on the modulation of fibrotic endothelial gene-expression patterns during sepsis and to determine the effects on sepsis outcomes. Our results indicate that the consumption of supplements based on ω-3 fatty acids and polyphenolic antioxidant flavonoids was effective for improving endotoxemia outcomes through prophylactic ingestion and therapeutic usage. Thus, our findings indicated that specific nutrient consumption improves sepsis outcomes and should be considered in treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats

et al. 2023

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“…LUT showed promise in improving pulmonary vascular remodeling and endothelial function, modulating the HIF‐2α‐Arg‐NO axis, PI3K‐AKT‐eNOS‐NO (Ji et al, 2022), and Hippo‐YAP/PI3K/AKT signaling pathways (Zuo et al, 2021). In Swiss Albino mice with sepsis‐induced vascular paralysis (via cecal ligation and puncture), LUT acted through the iNOS pathway to alleviate vascular dysfunction and improve endothelial function (Rungsung et al, 2022). LUT further exhibited anti‐inflammatory effects, inhibiting macrophage inflammation, plaque development, lipid accumulation, and atherosclerosis through various pathways, such as signal transducers and STAT3 (Ding et al, 2019), Nox4/ROS‐NF‐κB and MAPK (Xia et al, 2014).…”

Section: Bioactivities Of Lutmentioning

confidence: 99%

Luteolin: A promising multifunctional natural flavonoid for human diseases

Zhu,

Sun,

et al. 2024

Phytotherapy Research

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Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It is noteworthy that LUT exhibits a variety of beneficial pharmacological properties and holds significant potential for clinical applications, particularly in antitumor, anti‐convulsion, diabetes control, anti‐inflammatory, neuroprotection, anti‐oxidation, anti‐cardiovascular, and other aspects. The potential mechanism of action has been partially elucidated, including the mediation of NF‐κB, toll‐like receptor, MAPK, Wnt/β‐catenin, PI3K/Akt, AMPK/mTOR, and Nrf‐2, among others. The review that aimed to comprehensively consolidate essential information on natural sources, pharmacological effects, therapeutic and preventive potential, as well as potential mechanisms of LUT. The objective is to establish a theoretical basis for the continued development and application of LUT.

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Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury

Wen,

Han,

Chen

et al. 2024

Toxicon

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Luteolin alleviates vascular dysfunctions in CLP-induced polymicrobial sepsis in mice

Cited by 4 publications

References 50 publications

Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats

Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats

Luteolin: A promising multifunctional natural flavonoid for human diseases

Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury

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