Luteolin as an anti-inflammatory and neuroprotective agent: A brief review

Nabavi, Seyed Fazel; Braidy, Nady; Gortzi, Olga; Sobarzo‐Sánchez, Eduardo; Daglia, Maria; Skalicka-Woźniak, Krystyna

doi:10.1016/j.brainresbull.2015.09.002

Cited by 373 publications

(235 citation statements)

References 125 publications

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“…Presence of hydroxyl moieties and 2-3 carbon double bond are responsible for its several biochemical and pharmacological activities [18,19] like anti-inflammatory, antioxidant [6,[18][19][20][21][22], anticancer [18,22], antimicrobial [19,22], anti-allergic [22], anti-diabetic [19]. These evidence indicated that many biological activities of Luteolin (e.g.…”

Section: Introductionmentioning

confidence: 92%

“…Hemostasis, inflammation, proliferation and remodeling are important steps of this process [6,13,14]. Previous studies indicated that because of hydroxyl moieties and 2-3 carbon double bond in molecule structure is responsible from Luteolin's several activities [18,19] including anti-inflammatory, antioxidant [6,18,19,20,22] and antimicrobial [5,19,22] which effected wound healing process positively [35]. Therefore, healing potential of Luteolin in persistent dermal wounds such as chronic wounds or ulcers can be supported by these activities and also explain effectiveness of Luteolin ointments on excision and incision wound models in nondiabetic and diabetic rats in our study.…”

Section: Histopathological Studymentioning

confidence: 99%

“…Because of these reasons alternative treatment approaches are needed for wound healing [3]. The use of medicinal plants or their bioactive components which are responsible for the pharmacological effects of them are opening a new strategies for the treatment of wounds [4,18].…”

Section: Introductionmentioning

confidence: 99%

“…Literature data indicated that more than 8000 individual flavonoids [18] have been identified and classified into various sub-groups including flavonols, flavones, flavanols, flavanones, isoflavones [18,19]. Moreover, antioxidant [18,20], anti-inflammatory, anticancer [18,20,21], neuro-protective and cardioprotective effects [18] of these components have been reported in many studies.…”

Section: Introductionmentioning

confidence: 99%

“…Luteolin (3',4',5,7-tetrahydroxyflavone), which is naturally distributed among several plant species such as medicinal plants, vegetables and fruits [18,21,22], is structurally classified under the group of flavones [18][19][20]. Presence of hydroxyl moieties and 2-3 carbon double bond are responsible for its several biochemical and pharmacological activities [18,19] like anti-inflammatory, antioxidant [6,[18][19][20][21][22], anticancer [18,22], antimicrobial [19,22], anti-allergic [22], anti-diabetic [19].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Özay¹,

Güzel²,

Erdoğdu³

et al. 2018

Rec.Nat.Prod.

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Luteolin, which is structurally classified under the flavonoids, is naturally distributed abundant among medicinal plants, vegetables and fruits. The wound healing effects of Luteolin ointments were evaluated for incision and excision wound models on non-diabetic and Streptozotocin induced diabetic rats by using macroscopical, biomechanical, biochemical and histopathological methods. Two different concentrations (0.5 % and 1 % (w/w)) of the Luteolin ointment were prepared with the mixture of glycol stearate:propylene glycol:liquid paraffin (3:6:1) and 0.5 g of the ointments were applied topically on wounds once daily for 7 and 14 days. During the experiments, wounds were visually observed, photographically documented and wound areas were measured. After 7 and 14 days treatment, animals were sacrificed under anesthesia and hydroxyproline measurement and biomechanical analysis were performed. Histopathology of the wound area was evaluated considering features of re-epithelialization, thickness of the granulation tissue, angiogenesis, presence of inflammation, number of mast cells. Outcomes of this study revealed that Luteolin ointments improved wound healing process of skin tissue both in non-diabetic and diabetic wounds. The best wound healing activity was observed in incision and excision wounds (97.6 %, 96.1 %, respectively) treated with 0.5 % (w/w) Luteolin ointment on day 14 according to macroscopic results.

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Section: Introductionmentioning

confidence: 92%

Section: Histopathological Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Özay¹,

Güzel²,

Erdoğdu³

et al. 2018

Rec.Nat.Prod.

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Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

et al. 2020

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Neuroinflammation leads to neurodegeneration, cognitive defects, and neurodegenerative disorders. Neurotrauma/traumatic brain injury (TBI) can cause activation of glial cells, neurons, and neuroimmune cells in the brain to release neuroinflammatory mediators. Neurotrauma leads to immediate primary brain damage (direct damage), neuroinflammatory responses, neuroinflammation, and late secondary brain damage (indirect) through neuroinflammatory mechanism. Secondary brain damage leads to chronic inflammation and the onset and progression of neurodegenerative diseases. Currently, there are no effective and specific therapeutic options to treat these brain damages or neurodegenerative diseases. Flavone luteolin is an important natural polyphenol present in several plants that show anti-inflammatory, antioxidant, anticancer, cytoprotective, and macrophage polarization effects. In this short review article, we have reviewed the neuroprotective effects of luteolin in neurotrauma and neurodegenerative disorders and pathways involved in this mechanism. We have collected data for this study from publications in the PubMed using the keywords luteolin and mast cells, neuroinflammation, neurodegenerative diseases, and TBI. Recent reports suggest that luteolin suppresses systemic and neuroinflammatory responses in Coronavirus disease 2019 . Studies have shown that luteolin exhibits neuroprotective effects through various mechanisms, including suppressing immune cell activation, such as mast cells, and inflammatory mediators released from these cells. In addition, luteolin can suppress neuroinflammatory response, activation of microglia and astrocytes,

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Role of luteolin in overcoming Parkinson's disease

Siddique

2021

BioFactors

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Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting elderly people (>60 years old) worldwide. There is no permanent cure for the disease but the symptomatic relief can be obtained by using dopamine agonists besides L-dopa therapy. The longer use of the drugs is associated with several side effects. Hence, the researchers have made a considerable attention toward the development of neuroprotective agents from plants. A number of phytochemicals have been demonstrated for their protective effects in various in vitro, in vivo, and clinical studies. In this context, luteolin, a flavone which is present in fruits and vegetables has been attributed to a number of pharmacological properties including neuroprotective. The present review demonstrates the bioavailability, oral absorption, and mechanism of action against PD.

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Luteolin as an anti-inflammatory and neuroprotective agent: A brief review

Cited by 373 publications

References 125 publications

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

Role of luteolin in overcoming Parkinson's disease

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