Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities

Zuiki, Masashi; Chiyonobu, Tomohiro; Yoshida, Michiko; Maéda, Hiroshi; Yamashita, Satoshi; Kidowaki, Satoshi; Hasegawa, Tatsuhisa; Gotoh, Hitoshi; Nomura, Tadashi; Ono, Katsuhiko; Hosoi, Hajime; Morimoto, Masafumi

doi:10.1016/j.neulet.2017.06.004

Cited by 26 publications

(20 citation statements)

References 30 publications

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“…Similarly, luteolin, beta-sitosterol, Stigmasterol and kaempferol, which were extensively distributed in this formula, also exhibit various pharmacological properties and participate in regulating multiple physiological and pathological processes, such as inflammation, immune response and stress [39][40][41][42] .…”

Section: Screening Of Candidate Compounds For Acgmentioning

confidence: 99%

Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

et al. 2021

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An-Chuan Granule (ACG), a traditional Chinese medicine (TCM) formula, is an effective treatment for asthma but its pharmacological mechanism remains poorly understood. In this study, network pharmacology was applied to explore the potential mechanism of ACG in the treatment of asthma. The tumor necrosis factor (TNF), toll-like receptor (TLR), and Th17 cell differentiation-related, nucleotide-binding oligomerization domain (NOD)-like receptor, and NF-kappaB pathways were identified as the most significant signaling pathways involved in the therapeutic effect of ACG on asthma. A mouse asthma model was established using ovalbumin (OVA) to verify the effect of ACG and the underlying mechanism. The results showed that ACG treatment not only attenuated the clinical symptoms, but also reduced inflammatory cell infiltration, mucus secretion and MUC5AC production in lung tissue of asthmatic mice. In addition, ACG treatment notably decreased the inflammatory cell numbers in bronchoalveolar lavage fluid (BALF) and the levels of pro-inflammatory cytokines (including IL-6, IL-17, IL-23, TNF-alpha, IL-1beta and TGF-beta) in lung tissue of asthmatic mice. In addition, ACG treatment remarkably down-regulated the expression of TLR4, p-P65, NLRP3, Caspase-1 and adenosquamous carcinoma (ASC) in lung tissue. Further, ACG treatment decreased the expression of receptor-related orphan receptor (RORγt) in lung tissue but increased that of Forkhead box (Foxp3). In conclusion, the above results demonstrate that ACG alleviates the severity of asthma in a “multi-compound and multi-target” manner, which provides a basis for better understanding of the application of ACG in the treatment of asthma.

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Section: Screening Of Candidate Compounds For Acgmentioning

confidence: 99%

Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

et al. 2021

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“…Nevertheless, when LPS was co-administered with an IL-6 blocking antibody, the observed reduction of neurogenesis was salvaged suggesting an essential role for IL-6 in mediating changes in NSC/NPC differentiation in the DG ( Mouihate, 2016 ). In a 3D neural differentiation model, referred to by the authors as “neural aggregates” that resembled neurospheres, IL-6 exposure did not affect neural aggregate size ( Zuiki et al, 2017 ). Instead, it decreased the more mature TBR1 + /CTIP2 + cell population’s area ratio (stage 5 of Fig.…”

Section: Prenatal Immune Challenge Alters Hippocampal Neurogenesismentioning

confidence: 99%

Maternal immune activation primes deficiencies in adult hippocampal neurogenesis

Couch

Berger

Hanger

et al. 2021

Brain, Behavior, and Immunity

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“…It was reported that luteolin can reduce maternal immune activation-induced neural abnormalities, such as ASD [ 75 ]. In addition, Asadi and Theoharides [ 56 ] reported that it can be utilized in ASD treatment, as luteolin inhibited mast-cell activation due to allergy augmentation and mitochondria stimulation.…”

Section: Bioactive Molecules: An Upcoming Key In Autism Spectrum Diseasementioning

confidence: 99%

Paving Plant‐Food‐Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder

Cruz‐Martins

Quispe

Kırkın

et al. 2021

Oxidative Medicine and Cellular Longevity

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, luteolin, and resveratrol have revealed excellent neuroprotective effects and can be effectively used in the treatment of neuropsychological disorders. However, the number of clinical trials is limited, and none of them have been approved for the treatment of autism or autism-related disorder. Further clinical studies are needed to effectively assess the real potential of such bioactive molecules.

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Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities

Cited by 26 publications

References 30 publications

Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

Maternal immune activation primes deficiencies in adult hippocampal neurogenesis

Paving Plant‐Food‐Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder

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