Luteolysis in Ruminants: Past Concepts, New Insights, and Persisting Challenges

Meidan, Rina; Girsh, Eliezer; Mamluk, Roni; Levy, Nitzan; Farberov, Svetlana

doi:10.1007/978-3-319-43238-0_9

Cited by 11 publications

(10 citation statements)

References 133 publications

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“…It was recently reported that the expression of THBS1 was downregulated in bovine CL slices and cultured luteal ECs incubated with IFNt (Basavaraja et al 2017). The same study also found that IFNt reduced TGFB1 and SERPINE1, which are interconnected with THBS1, during luteolysis (Farberov & Meidan 2016, Meidan et al 2017. Inhibition of the THBS1-TGFB1-SEPRINE1 feed-forward process may be critical for maintaining the CL during early pregnancy.…”

Section: Hormonal Regulation and Expression Patterns Of Thrombospondimentioning

confidence: 78%

“…Endogenous PGF2a or its exogenous administration initiates a cascade of events leading to the irreversible demise of the CL. During this process, the CL undergoes dramatic changes in its steroidogenic capacity, vascularization, extracellular matrix (ECM) remodeling and cell viability (Schams & Berisha 2004, Miyamoto et al 2010, Meidan et al 2017). An intriguing question concerning bovine luteal function is its refractoriness to the luteolytic actions of PGF2a in the early luteal phase, which lasts up to day 5 of the bovine estrous cycle (Lauderdale 2009).…”

Section: Introductionmentioning

confidence: 99%

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Thrombospondin-1 at the crossroads of corpus luteum fate decisions

Farberov¹,

Basavaraja²,

Meidan³

2019

Reproduction

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The multimodular matricellular protein thrombospondin-1 (THBS1) was among the first identified endogenous antiangiogenic molecules. Recent studies have shown THBS1-mediated suppression of angiogenesis and other critical activities for corpus luteum (CL) regression. THBS1 is specifically induced by prostaglandin F2alpha in mature CL undergoing regression, whereas luteinizing signals such as luteinizing hormone and insulin reduced its expression. THBS1 interacts both synergistically and antagonistically with other essential luteal factors, such as fibroblast growth factor 2, transforming growth factor beta1 and serpin family E member 1, to promote vascular instability, apoptosis and matrix remodeling during luteal regression. Expression of THBS1 is also downregulated by pregnancy recognition signals to maintain the CL during early pregnancy. This dynamic pattern of luteal expression, the extensive interactivity with other luteal factors and strong antiangiogenic and proapoptotic activities indicate that THBS1 is a major determinant of CL fate.

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Section: Hormonal Regulation and Expression Patterns Of Thrombospondimentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Thrombospondin-1 at the crossroads of corpus luteum fate decisions

Farberov¹,

Basavaraja²,

Meidan³

2019

Reproduction

Self Cite

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“…The first intracellular step Endostatin +/− Acts as inhibitor of endothelial cell proliferation and migration and angiogenesis and induces endothelial apoptosis [56] TGF-β1 +/− Angiogenic inhibitor [57] Platelet factor 4 (PF4) +/− Angiogenic inhibitor [58] Serpin B5 +/− Maspin. A member of the serine protease inhibitor family and negative regulator of angiogenesis [59] Serpin E1 +/+ Serine protease inhibitor; inhibition of angiogenesis; inhibitor of uPA; preserves the vascular integrity [60] Serpin F1 +/+ Serine protease inhibitor, inhibition of angiogenesis [61] TIMP-1 +/+ Angiogenesis inhibitor [62] TIMP-4 +/+ Angiogenesis inhibitor [63] Thrombospondin in exosome biogenesis involves the invagination of the membrane of the multivesicular body (MVB) to form membrane-bound vesicles in MVB lumens that are identified as intraluminal vesicles (ILVs) (Figure 1) [83,84]. Various factors and signaling pathways have been considered in biogenesis, trafficking, and abscission of exosomes [85].…”

Section: Exosomes Biogenesismentioning

confidence: 99%

The Angiogenic Paracrine Potential of Mesenchymal Stem Cells

Rezaie¹,

Heidarzadeh²,

Hassanpour³

et al. 2020

Update on Mesenchymal and Induced Pluripotent Stem Cells

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Tissue engineering and regenerative medicine are branches of biomedical sciences that facilitate the use of cells and biocompatible scaffolds in favor of tissue restoration. In this regard, restoration and maintenance of angiogenesis and blood supplementation could be an effective strategy for injured tissue removal, accelerating healing rate, and successful transplantation of cells and scaffolds into target sites. It has been elucidated that mesenchymal stem cells have the potency to promote angiogenesis via paracrine activity and trans-differentiation into the endothelial lineage. In this chapter, we highlighted the paracrine property of mesenchymal stem cells to modulate angiogenesis in the target tissues.

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“…Either luteal endothelial and steroidogenic cells showed this ability in vitro ( 52 , 53 ). It has been then suggested that PTX3 might participate in the involution of microvasculature during corpus luteum regression by sequestering FGF2 and preventing its pro-angiogenic activity ( 53 , 54 ) (Figure 1 ). In contrast, one study performed in sheep reported that PTX3 expression is downregulated during physiological regression of corpus luteum while it is maintained in gravidic corpus luteum ( 55 ).…”

Section: Ptx3 Expression In the Ovarymentioning

confidence: 99%

The Influence of Pentraxin 3 on the Ovarian Function and Its Impact on Fertility

et al. 2018

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Follicular development is a highly coordinated process that in humans takes more than 6 months. Pituitary gonadotropins and a variety of locally produced growth factors and cytokines are involved in determining a precise sequence of changes in cell metabolism, proliferation, vascularization, and matrix remodeling in order to obtain a follicle with full ovulatory and steroidogenic capability. A low-grade inflammation can alter such processes leading to premature arrest of follicular growth and female reproductive failure. On the other hand, factors that are involved in inflammatory response as well as in innate immunity are physiologically upregulated in the follicle at the final stage of maturation and play an essential role in ovulation and fertilization. The generation of pentraxin 3 (PTX3) deficient mice provided the first evidence that this humoral pattern recognition molecule of the innate immunity has a non-redundant role in female fertility. The expression, localization, and molecular interactions of PTX3 in the periovulatory follicle have been extensively studied in the last 10 years. In this review, we summarize findings demonstrating that PTX3 is synthesized before ovulation by cells surrounding the oocyte and actively participates in the organization of the hyaluronan-rich provisional matrix required for successful fertilization. Data in humans tend to confirm these findings, indicating PTX3 as a biomarker of oocyte quality. Moreover, we discuss the emerging evidence that in humans altered PTX3 systemic levels, determined by genetic variations and/or low-grade chronic inflammation, can also impact the growth and development of the follicle and affect the incidence of ovarian disorders.

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Luteolysis in Ruminants: Past Concepts, New Insights, and Persisting Challenges

Cited by 11 publications

References 133 publications

Thrombospondin-1 at the crossroads of corpus luteum fate decisions

Thrombospondin-1 at the crossroads of corpus luteum fate decisions

The Angiogenic Paracrine Potential of Mesenchymal Stem Cells

The Influence of Pentraxin 3 on the Ovarian Function and Its Impact on Fertility

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