Luteoma of Pregnancy Associated with Nearly Complete Virilization of Genetically Female Twins

Wadzinski, Thomas L.; Altowaireb, Yousef; Gupta, Rashim; Conroy, Rushika; Shoukri, Kamal

doi:10.4158/ep13056.cr

Cited by 17 publications

(22 citation statements)

References 14 publications

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“…All hormones act by binding to a specific receptor or receptors 1 . Inappropriate receptor activation can have profound negative effects on development and health, as illustrated by the formation of a scrotum and penis in genetic female humans exposed to androgens during gestation 31 . EDCs that inappropriately bind to and/or activate hormone receptors can produce adverse biological effects.…”

Section: Key Characteristics Of Edcsmentioning

confidence: 99%

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

et al. 2019

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Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.

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Section: Key Characteristics Of Edcsmentioning

confidence: 99%

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

et al. 2019

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“…Human luteomas are rare benign tumors occurring either in pregnancy or after menopause [31]. Human gestational luteomas are spontaneously regressing tumors which may cause virilization of female fetuses due to their androgen secretion [21,32]. Only two cases of canine ovarian luteoma have been described [12,33] with both cases developing from ovarian remnants in spayed bitches.…”

Section: Discussionmentioning

confidence: 99%

Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch

et al. 2020

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Background: This is the first report about a vaginal leiomyoma concomitant with an ovarian luteoma in a bitch. Case presentation: A 11-year-old intact female Labrador retriever was referred because of anuria, constipation and protrusion of a vaginal mass through the vulvar commissure. The bitch had high serum progesterone concentration (4.94 ng/ml). Because of the possibility of progesterone responsiveness causing further increase of the vaginal mass and since the bitch was a poor surgical candidate a 10 mg/kg aglepristone treatment was started SC on referral day 1. A computerized tomography showed a 12.7 × 6.5 × 8.3 cm mass causing urethral and rectal compression, ureteral dilation and hydronephrosis. A vaginal leiomyoma was diagnosed on histology. As serum progesterone concentration kept increasing despite aglepristone treatment, a 0.02 ng/mL twice daily IM alfaprostol treatment was started on day 18. As neither treatment showed remission of clinical signs or luteolysis, ovariohysterectomy was performed on referral day 35. Multiple corpora lutea were found on both ovaries. On histology a luteoma was diagnosed on the left ovary. P4 levels were undetectable 7 days after surgery. Recovery was uneventful and 12 weeks after surgery tomography showed a reduction of 86.7% of the vaginal mass. The bitch has been in good health and able to urinate without any complication ever since. Conclusions: This case demonstrates the importance of identifying progesterone related conditions as well as the importance of judiciously using a combined medical and surgical approach.

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“…EDCs can affect the endocrine system through nine modes of action (Figure 2). Inappropriate activation/binding of hormone receptors by EDCs could lead to negative effects on human health [8]. Some of the above-mentioned EDCs inappropriately activate the estrogen receptor during the developmental stage, which results in infertility in both the sexes.…”

Section: Mechanism Of Action Of Edcsmentioning

confidence: 99%

Environmental Contamination and Human Exposure to Select Endocrine-Disrupting Chemicals: A Review

Seethappan

Vimalkumar

Loganathan

2021

Sustainable Chemistry

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Endocrine-disrupting compounds (EDCs) are exogenous compounds that interfere with the normal hormone functions and ultimately lead to health disorders. Parabens, phenols, and phthalates are well-known EDCs, produced globally in large quantities and widely used in a variety of applications. Several studies have monitored these compounds in a variety of environmental matrices, including air, water, sediment, fish, human tissues, soil, indoor dust, and biosolids, etc. In recent years, environmental contamination and human exposure to these chemicals have become a great concern, due to their residue levels exceeding the permissible/acceptable limits. In this review, we focus on the origin of these EDCs, aquatic contamination pathways, distribution, human exposure, health implications, and healthcare costs. Further, this review identifies critical challenges and future research needs in removing or minimizing environmental contamination and exposure to these chemicals to protect living resources.

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Luteoma of Pregnancy Associated with Nearly Complete Virilization of Genetically Female Twins

Cited by 17 publications

References 14 publications

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch

Environmental Contamination and Human Exposure to Select Endocrine-Disrupting Chemicals: A Review

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