Lyases

Mahdi, Jassem G.; Kelly, David R.

doi:10.1002/9783527620913.ch2

Biotechnology 2000

DOI: 10.1002/9783527620913.ch2

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Lyases

Jassem G. Mahdi¹,

David R. Kelly²

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2011

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Preparation of Unnatural Amino Acids with Ammonia-Lyases and 2,3-Aminomutases

Poppe

Paizs

Kovács

et al. 2011

Methods in Molecular Biology

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Ammonia-lyases catalyze a wide range of processes leading to α,β-unsaturated compounds by elimination of ammonia. In this chapter, ammonia-lyases are reviewed with major emphasis on their synthetic applications in stereoselective preparation of unnatural amino acids. Besides the synthesis of various unnatural α-amino acids with the aid of phenylalanine ammonia-lyases (PALs) utilizing the 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO) prosthetic groups, the biotransformations leading to various unnatural β-amino acids with phenylalanine 2,3-aminomutases using the same catalytic MIO prosthetic group are discussed. Cloning, production, purification, and biotransformation protocols for PAL are described in detail.

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Preparation of Unnatural Amino Acids with Ammonia-Lyases and 2,3-Aminomutases

Poppe

Paizs

Kovács

et al. 2011

Methods in Molecular Biology

View full text Add to dashboard Cite

show abstract

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Lyases

Cited by 1 publication

References 670 publications

Preparation of Unnatural Amino Acids with Ammonia-Lyases and 2,3-Aminomutases

Preparation of Unnatural Amino Acids with Ammonia-Lyases and 2,3-Aminomutases

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