2011
DOI: 10.1007/978-1-61779-331-8_1
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Preparation of Unnatural Amino Acids with Ammonia-Lyases and 2,3-Aminomutases

Abstract: Ammonia-lyases catalyze a wide range of processes leading to α,β-unsaturated compounds by elimination of ammonia. In this chapter, ammonia-lyases are reviewed with major emphasis on their synthetic applications in stereoselective preparation of unnatural amino acids. Besides the synthesis of various unnatural α-amino acids with the aid of phenylalanine ammonia-lyases (PALs) utilizing the 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO) prosthetic groups, the biotransformations leading to various unnatural β-a… Show more

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Cited by 28 publications
(27 citation statements)
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“…Performing Multiparameter Experiments in MagneChip. The experiments in Magne-Chip involved four steps: (1) filling up the chip with MNPs, (2) absorbance calibration, (3) experiment cycles, and (4) chip cleaning.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…Performing Multiparameter Experiments in MagneChip. The experiments in Magne-Chip involved four steps: (1) filling up the chip with MNPs, (2) absorbance calibration, (3) experiment cycles, and (4) chip cleaning.…”
Section: Resultsmentioning
confidence: 99%
“…Phenylalanine Ammonia-Lyase (PAL). Phenylalanine ammonia-lyase (PAL; EC 4.3.1.24), catalyzing the nonoxidative deamination of L-phenylalanine (L-1a) into (E)-cinnamic acid (2a), is a member of the aromatic amino acid lyase family [1]. PAL is a key biosynthetic catalyst in phenyl-propanoid assembly in plants and fungi and is involved in the biosynthesis of a wide variety of secondary metabolites such as flavonoids, furanocoumarin phytoalexins, and cell wall components [2].…”
mentioning
confidence: 99%
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“…Phenylalanine ammonia-lyase from parsley (Petroselinum crispum, PcPAL) was obtained after overexpression in E. coli and purification using a previously reported protocol [14].…”
Section: Materials 211 Enzymementioning
confidence: 99%