Lycium barbarum lipid-based edible nanoparticles protect against experimental colitis

Zu, Menghang; Song, Heliang; Zhang, Jiabin; Chen, Qiubing; Deng, Shiqin; Canup, Brandon S.B.; Yuan, Yi; Xiao, Bo

doi:10.1016/j.colsurfb.2019.110747

Cited by 24 publications

(8 citation statements)

References 41 publications

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“…For instance, Bo et al [ 24 ] designed liposomes loaded with polysaccharides from L. barbarum berries with good efficiency and nanosize that effectively enhanced the process of phagocytosis of peritoneal macrophages by inducing the production of nitric oxide in mouse macrophage cells. Zu et al [ 25 ] obtained monodisperse and nano-size L. barbarum lipid-derived nanoparticles with great cellular uptake by macrophages, as well as a significant anti-inflammatory effect. Oral administration of L. barbarum lipid-derived nanoparticles provided desirable therapeutic efficacy against ulcerative colitis.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Polyphenols from Lycium barbarum Leaves into Liposomes as a Strategy to Improve Their Delivery

et al. 2021

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This study is focused on the encapsulation of polyphenols from Lycium barbarum leaves into liposomes as a strategy to improve their delivery. Liposomes loaded with Lycium barbarum leaves extract were obtained and characterized for particle size, polydispersity, entrapment efficiency, and stability. Liposomes presented entrapment efficiency higher than 75%, nanometric particle size, narrow polydispersity, and good stability over three months at 4 °C. The liposomes containing Lycium barbarum offered a slower release of polyphenols with attenuated burst effect compared with the dissolution of free Lycium barbarum extract in phosphate buffer solution at pH 7.4. Moreover, an in vitro pretreatment of 24 h with loaded liposomes showed a cytoprotective effect against H2O2-induced cytotoxicity on L-929 mouse fibroblasts cells. These preliminary findings imply that liposomes could be successfully employed as carriers for polyphenols in pharmaceutical applications.

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Section: Introductionmentioning

confidence: 99%

Encapsulation of Polyphenols from Lycium barbarum Leaves into Liposomes as a Strategy to Improve Their Delivery

et al. 2021

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“…These oral medications’ distribution profiles play a vital role in exerting their therapeutic effectiveness to UC . As shown in Figure A, after oral administration for 3 and 6 h, in the average fluorescence intensity among the Free-DiR, PEI-DiR NPs, HA/PEI-DiR NPs, and HA/PEI-DiR NYPs groups, there was no significant difference.…”

Section: Results and Discussionmentioning

confidence: 99%

Entrapment of Macrophage-Target Nanoparticles by Yeast Microparticles for Rhein Delivery in Ulcerative Colitis Treatment

et al. 2021

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In this study, we developed an advanced colitis-targeted nanoparticles (NPs)-into-yeast cell wall microparticles (YPs) drug delivery system for ulcerative colitis (UC) therapy. In brief, YPs entrap hyaluronic acid (HA), and polyethylenimine (PEI) modified rhein (RH)-loaded ovalbumin NPs (HA/PEI-RH NPs) to form HA/PEI-RH NYPs. YPs can make HA/PEI-RH NPs pass through gastric environment stably and be degraded by β-glucanase to promote drug release from HA/PEI-RH NYPs in the colon. Cellular uptake evaluation confirmed that HA/PEI-RH NPs could specifically target and enhance the uptake rate via HA ligands. In biodistribution studies, HA/PEI-RH NYPs were able to efficiently accumulate in the inflammed colon in mice. In vivo experiments revealed that the HA/PEI-RH NYPs could significantly alleviate inflammation by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Therefore, HA/PEI-RH NYPs have advantages of good gastric stability, β-glucanase-sensitive release ability, macrophagetargeted ability, and anti-UC effects. These advantages indicate YPs-entrapped multifunctional NPs are a promising oral drug delivery system for UC therapy.

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“…Lipid-based nanoparticles were derived from goji berries, specifically from the lipid contents extracted from goji berries [ 150 ]. The lipidomic analysis of the obtained nanoparticles was performed, as well as the analysis of the bioactive flavone.…”

Section: Processing Of Goji Berriesmentioning

confidence: 99%

Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review

et al. 2022

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Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due to wide-range bioactive compounds with health-promoting properties. In addition, they are gaining increased research attention as a source of functional ingredients with potential industrial applications. This review focuses on the antioxidant properties of goji berries, scientific evidence on their health effects based on human interventional studies, safety concerns, goji berry processing technologies, and applications of goji berry-based ingredients in developing functional food products.

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Lycium barbarum lipid-based edible nanoparticles protect against experimental colitis

Cited by 24 publications

References 41 publications

Encapsulation of Polyphenols from Lycium barbarum Leaves into Liposomes as a Strategy to Improve Their Delivery

Encapsulation of Polyphenols from Lycium barbarum Leaves into Liposomes as a Strategy to Improve Their Delivery

Entrapment of Macrophage-Target Nanoparticles by Yeast Microparticles for Rhein Delivery in Ulcerative Colitis Treatment

Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review

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