Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide

Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-κB in macrophages

“…Cell culture studies also showed that lycopene has antiproliferative and proapoptotic effects on various cancer cell lines [6,7]. Apart from the antioxidant and anticancer effects, lycopene was found to have anti-inflammatory effects in the airway [8,9], prostate [10], and colon [11,12], which are believed to be related to inhibition of the formation of several proinflammatory molecules such as nitric oxide (NO), interleukins, TNF-a, cyclooxygenase, and NF-jB, depending on the cell types and stimuli [13,14]. While the anti-inflammatory effects of lycopene have been indicated in many studies, the mechanisms underlying these effects and the signal transduction pathway affected by lycopene remain elusive.…”

Efficacy of lycopene against fluoride toxicity in rats

“…The ability of it to detoxify cells by up-regulating the GSH-mediated detoxification process was recently evidenced (Koul et al, 2010). In addition, lycopene exerts potent anti-inflammatory effect through its action as an anti-oxidant and freeradical scavenger, which may reduce cellular damage (Saedisomeolia et al, 2009). These findings were confirmed by the existing reduction of MDA and NO(x) production, in addition to the obvious restoring of the endogenous anti-oxidant status through the increased levels of GSH, SOD and TAC in red blood cells and examined organs of rats that received both lycopene and fluoride.…”

Barrier protective effects of lycopene in human endothelial cells

“…Furthermore, accumulating evidence suggests that other mechanisms such as modulation of intracellular gap junction communication, metabolic pathways and the immune system may also be involved in the antioxidant effects of lycopene [16][17][18]. Aside from these effects, lycopene has anti-inflammatory effects in several tissues by inhibition of the formation of some proinflammatory molecules such as nitric oxide, interleukins and cyclo-oxygenase [19][20][21]. Nevertheless, the effects of lycopene on vascular integrity and barrier protection and the mechanism underlying these effects remain elusive.…”