The industrial processing of tomato leads to substantial amounts of residues, typically known as tomato pomace or by-products, which can represent as much as 10% by weight of fresh tomatoes. At present, these residues are either used as feedstock for animals or, in the worst case, disposed of in landfills. This represents a significant waste because tomato pomace contains high-value compounds like lycopene, a powerful antioxidant, cutin, which can be used as a starting material for biopolymers, and pectin, a gelling agent. This article presents an overview of technologies that valorize tomato by-products by recovering added-value compounds as well as generating fuel for energy production. These technologies include operations for extraction, separation, and exploitation of lycopene, cutin and pectin, as well as the processes for conversion of the solid residues to fuels. Data collected from the review has been used to develop a biorefinery scheme with the related mass flow balance, for a scenario involving the tomato supply chain of Regione Campania in Italy, using tomato by-products as feedstock.