Lycopene in protection against obesity and diabetes: A mechanistic review

Zhu, Ruyuan; Chen, Beibei; Bai, Ying; Miao, Tianyi; Li, Rui; Zhang, Hao; Xia, Bingke; Liu, Yu; S, Gao; Wang, Xiangdong; Zhang, Dongwei

doi:10.1016/j.phrs.2020.104966

Cited by 95 publications

(78 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is scientific evidence which supports the beneficial role of lycopene against diabetes. Regarding animal studies and epidemiological surveys, it can be used for both the prevention and treatment of diabetes [92]. In a diabetic rat model (streptozotocin (STZ)-induced), lycopene decreased diabetes-associated pancreas injury and urine and blood glucose levels.…”

Section: Antidiabeticmentioning

confidence: 99%

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

et al. 2020

View full text Add to dashboard Cite

Lycopene, belonging to the carotenoids, is a tetraterpene compound abundantly found in tomato and tomato-based products. It is fundamentally recognized as a potent antioxidant and a non-pro-vitamin A carotenoid. Lycopene has been found to be efficient in ameliorating cancer insurgences, diabetes mellitus, cardiac complications, oxidative stress-mediated malfunctions, inflammatory events, skin and bone diseases, hepatic, neural and reproductive disorders. This review summarizes information regarding its sources and uses amongst different societies, its biochemistry aspects, and the potential utilization of lycopene and possible mechanisms involved in alleviating the abovementioned disorders. Furthermore, future directions with the possible use of this nutraceutical against lifestyle-related disorders are emphasized. Its protective effects against recommended doses of toxic agents and toxicity and safety are also discussed.

show abstract

Section: Antidiabeticmentioning

confidence: 99%

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The mechanisms by which how lycopene achieve its protective effect has not been well established. A proposed mechanism has suggested that lycopene may exert excellent antiinflammatory and antioxidant properties [8]. This is attributed by its ability to regulate the AGE/RAGE, JNK/MAPK, PI3K/Akt and SIRT1/FoxO1/PPARc signalling pathways and AchE activity.…”

Section: Discussionmentioning

confidence: 99%

“…Recent review by Zhu et al [8] also reported that tomato, a dominant fruit source of lycopene demonstrates a beneficial role in the management of T2DM, contributing to the lowering risk of obesity and diabetes. Such conclusion was drawn mainly with reference to the animal studies and epidemiological investigations.…”

Section: Introductionmentioning

confidence: 99%

The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Lycopene can also protect against acute pancreatitis and diabetes (e.g., Refs. 114,115). Accordingly, lycopene may currently be used in a preventative setting.…”

Section: Lycopenementioning

confidence: 99%

Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities

Djamgoz

Jentzsch

2021

Nutrition and Cancer

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. The standard first-line treatment for PDAC is gemcitabine chemotherapy which, unfortunately, offers only limited chance of a lasting cure. This review further evaluates the hypothesis that the effectiveness of gemcitabine can be improved by combining it with evidence-based complementary measures. Previously, supported by clinical trial data, we suggested that a number of dietary factors and nutraceuticals can be integrated with gemcitabine therapy. Here, we evaluate a further 10 agents for which no clinical trials have (yet) been carried out but there are promising data from in vivo and/or in vitro studies including experiments involving combined treatments with gemcitabine. Two groups of complementary agents are considered: Dietary factors (resveratrol, epigallocatechin gallate, vitamin B9, capsaicin, quercetin and sulforaphane) and nutraceutical agents (artemisinin, garcinol, thymoquinone and emodin). in addition, we identified seven promising agents for which there is currently only basic (mostly in vitro) data. Finally, as a special case of combination therapy, we highlighted synergistic drug combinations involving gemcitabine with "repurposed" aspirin or metformin. we conclude overall that integrated management of PDAC currently is likely to produce the best outcome for patients and for this a wide range of complementary measures is available.

show abstract

Lycopene in protection against obesity and diabetes: A mechanistic review

Cited by 95 publications

References 141 publications

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities

Contact Info

Product

Resources

About