Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals

Serum- and HDL3-serum amyloid A and HDL3-LCAT activity are influenced by increased CVD-burden

“…However, we were able to demonstrate that serum-SAA was related to the degree of CVD-burden and that a strength of this study was the fact that none of our subjects were on lipid-lowering medication, especially statins, which are known to lower SAA[41], thus removing any confounding influence that these drugs may have displayed on our findings. Our findings are consistent with previous studies that have proposed serum-SAA as sensitive biomarker to illustrate increased inflammation [3,[27][28]. In the circulation, SAA rapidly associates with HDL, where it renders this lipoprotein dysfunctional with numerous proinflammatory actions [9][10][11], which include reduced antioxidant capacity [15] and reduced RCT capabilities [10].…”

Postprandial Paraoxonase 1 Activity Following Consumption of Recommended Amounts of Mixed Meals in Healthy Males

“…Therefore, changes in PON1 activity with the consumption of vegetables following ordinary meals may not occur in the postprandial state, as was in case of a study with blackcurrant juice, which is rich in water-soluble antioxidant polyphenols and ascorbic acid 26) . On the other hand, prior reports on human studies have shown that the intake of antioxidants exerts beneficial effects on PON1 activity [27][28][29][30][31] . Further research is required to determine the optimal quality and quantity of vegetables, duration of intervention, and health status of subjects.…”

Nutraceuticals with lipid-lowering activity: do they have any effect beyond cholesterol reduction?

“…Moreover, the lycopene supplementation improves the HDL-cholesterol functionality by decreasing CETP activity and increasing that of LCAT [100]. Combined with the antioxidant and antiinflammatory effect, this action could be related to improving the effect of lycopene on FMD [101].…”