Nutraceuticals with lipid-lowering activity: do they have any effect beyond cholesterol reduction?

Cicero, Arrigo F G; Tartagni, E.; Borghi, Claudio

doi:10.2217/clp.12.55

Cited by 6 publications

(3 citation statements)

References 109 publications

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“…Epidemiological studies show that dietary supplementation of nutraceuticals such as catechins, linolenic acid, anthocyanin, lycopene, resveratrol and saponin glycosides can decrease the incidence of diseases (Cencic and Chingwaru, 2010;Aschemann-Witzel and Grunert, 2015;Ruchi, 2017). Studies have shown that nutraceuticals have the property to inhibit prostate cancer growth (Salami et al, 2013), protect against cardiovascular disease (Sosnowska et al, 2017), control cholesterol levels (Cicero et al, 2012) and andrologic disorders (Tamler and Mechanick, 2007), maintain gastrointestinal health (Romano et al, 2012) and retard degenerative disorders (Pasrija et al, 2015). Diarylheptanoids, also known as dipheylheptanoids, fall under the class of plant secondary metabolites derived from various plant sources (Table 1).…”

Section: Diarylheptanoids and Dietary Supplementsmentioning

confidence: 99%

Diarylheptanoids as nutraceutical: A review

Ganapathy

Preethi

Moses

et al. 2019

Biocatalysis and Agricultural Biotechnology

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Phenolic compounds are naturally occurring compounds present ubiquitously in plants. They have potential health benefits and substantiate evidence for their nutraceutical applications. Diarylheptanoids are part of the broad class of plant phenolics with structurally divergent compounds. They have been used in traditional medicines and homemade remedies to treat various ailments, as organoleptic additives in foods, and also for aesthetic purposes. With their potential therapeutic and organoleptic characteristics, diarylhepatanoids can be rightly termed as nutraceuticals. This review summarizes the wide range of pharmacological activities of diarylhepatanoids and nutraceutical formulations, with relevance to human health.

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Section: Diarylheptanoids and Dietary Supplementsmentioning

confidence: 99%

Diarylheptanoids as nutraceutical: A review

Ganapathy

Preethi

Moses

et al. 2019

Biocatalysis and Agricultural Biotechnology

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“…However the use of combination of nutraceuticals with different but synergic mechanism of action at lower and more safe dosages appear to be an interesting alternative. Red yeast rice reduces cholesterolemia directly by inhibiting the liver 3-hydroxy-3-methyl-glutaryl-Coenzime A reductase, while berberine by inhibiting the cleavage of the receptor for LDL-cholesterol from the liver cell membranes [20]. Fig.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Lipid-Lowering Nutraceutical on Pulse-Wave-Velocity in Hypercholesterolemic Patients with or without Chronic Kidney Disease

Cicero¹,

Parini²,

Rosticci³

et al. 2013

TOHYPERJ

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The recent literature has put a large interest on nutraceuticals with lipid lowering activity for the management of moderate cholesterolemia in subjects with mildly increased cardiovascular disease risk. The aim of our study was to evaluate the middle-term effect of a combined lipid-lowering nutraceutical on lipid parameters and aortic stiffness. For this study we consecutively enrolled 40 moderately hypercholesterolemic outpatients with mild-to-moderate chronic kidney disease (CKD) and 40 cross-matched hypercholesterolemic subjects without CKD. All the patient were treated daily with a combined nutraceutical containing red yeast rice (3 mg monacolin K) and berberine (500 mg). At the baseline and after 6 months of treatment we measured blood pressure, pulse wave velocity (PWV) and ematochemistry parameters. No significant change has been observed during the study in both groups regarding body mass index, blood pressure, liver transaminases, creatinin-phosfokinase and eGFR. In non CKD patients TC improved by (-21,6%), LDL-Cholesterol by (-24,2%), non HDL-Cholesterol (-24,0%) and TG (- 20,8%). In CKD patients TC improved by (-21,1%), LDL-Cholesterol by (-23,7%), non HDL-Cholesterol (-23,9%) and TG (- 20,4%). No difference among groups has been observed regarding the effects on lipid metabolism. The PWV has significantly improved in both groups (p<0.01) without differences between groups. In summary, a combined lipid-lowering nutraceutical improved lipid pattern and PWV in both non CKD and mild-tomoderate CKD patients.

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“…However, their effect on pulse wave velocity (PWV) has not been widely analyzed, especially in CKD patients. Red yeast rice decreases cholesterolemia directly via the inhibition of liver 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, while berberine hinder the cleavage of the receptor for LDL-cholesterol from the liver cell membranes [ 167 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

Are Nutraceuticals Beneficial in Chronic Kidney Disease?

et al. 2021

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Chronic kidney disease (CKD) is a worldwide health problem in which prevalence is constantly rising. The pathophysiology of CKD is complicated and has not been fully resolved. However, elevated oxidative stress is considered to play a vital role in the development of this disease. CKD is also thought to be an inflammatory disorder in which uremic toxins participate in the development of the inflammatory milieu. A healthy, balanced diet supports the maintenance of a good health status as it helps to reduce the risk of the development of chronic diseases, including chronic kidney disease, diabetes mellitus, and hypertension. Numerous studies have demonstrated that functional molecules and nutrients, including fatty acids and fiber as well as nutraceuticals such as curcumin, steviol glycosides, and resveratrol not only exert beneficial effects on pro-inflammatory and anti-inflammatory pathways but also on gut mucosa. Nutraceuticals have attracted great interest recently due to their potential favorable physiological effects on the human body and their safety. This review presents some nutraceuticals in which consumption could exert a beneficial impact on the development and progression of renal disease as well cardiovascular disease.

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Nutraceuticals with lipid-lowering activity: do they have any effect beyond cholesterol reduction?

Cited by 6 publications

References 109 publications

Diarylheptanoids as nutraceutical: A review

Diarylheptanoids as nutraceutical: A review

Effect of a Lipid-Lowering Nutraceutical on Pulse-Wave-Velocity in Hypercholesterolemic Patients with or without Chronic Kidney Disease

Are Nutraceuticals Beneficial in Chronic Kidney Disease?

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