Lymph-node metastasis in stage I and II sex cord stromal and malignant germ cell tumours of the ovary: A systematic review

Kleppe, Marjolein; Amkreutz, L.C.M.; Gorp, Toon Van; Slangen, Brigitte; Kruse, Arnold‐Jan; Kruitwagen, Roy F.P.M.

doi:10.1016/j.ygyno.2014.01.011

Cited by 21 publications

(12 citation statements)

References 13 publications

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“…Despite significant advances in ovarian cancer detection and research towards reducing recurrence rates, the five-year survival rate for patients with ovarian cancer has remained relatively stable for >20 years (1,2). The main obstacle for ovarian cancer therapy is disease recurrence, which is characterized by metastasis (3). For these reasons, the development of effective therapeutic strategies for ovarian cancer metastasis is urgently required.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1

Wen

Zhao

Liu

et al. 2015

Molecular Medicine Reports

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MicroRNAs, a group of small non-coding RNA molecules that are involved in gene silencing, function as fine‑tuning regulators during cancer progression. MicroRNA (miR)-148a has previously been demonstrated to be associated with ovarian cancer. However, whether miR‑148a influences the migration and invasion of ovarian cancer cells has remained elusive. In the present study, reverse transcription‑quantitative polymerase chain reaction and western blotting were conducted to examine mRNA and protein expression levels, respectively. Luciferase reporter assay was used to determine target relationship, and a Transwell assay was used to study cell migration and invasion. The results of the present study indicated that miR‑148a expression was markedly downregulated in ovarian cancer tissues compared with that of their matched normal adjacent tissues. In addition, miR‑148a expression levels were reduced in three ovarian cancer cell lines, SKOV3, OVCAR and A2780, when compared with those of HUM‑CELL‑0088 normal ovarian epithelial cells. Furthermore, sphingosine‑1‑phosphate receptor 1 (S1PR1), which is upregulated in ovarian cancer tissues and cell lines, was identified as a novel target of miR‑148a in SKOV3 ovarian cancer cells. The protein expression of S1PR1 was negatively regulated by miR‑148a in SKOV3 cells. Furthermore, overexpression of miR‑148a or inhibition of S1PR1 suppressed SKOV3 cell migration and invasion, while restoration of S1PR1 expression reversed the suppressive effect of miR‑148a upregulation on SKOV3 cell migration and invasion. In conclusion, it was hypothesized that miR‑148a may potentially be used as a molecular agent for the prevention and treatment of invasion and metastasis in ovarian cancer, while S1PR1 may present a promising target for clinical applications.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1

Wen

Zhao

Liu

et al. 2015

Molecular Medicine Reports

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“…A resent systematic review on lymph node metastasis in stage I and II sex cord stromal and malignant germ cell tumors of the ovary reports that surgical approach varied widely in different studies and complete staging procedure, as advised by FIGO (hysterectomy with bilateral salpingo-oophorectomy and infracolic omentectomy, biopsy of the diaphragmatic peritoneum, para-aortic gutters, pelvic and para-aortic lymphadenectomy) was performed in a small number of patients. [24,25,28] Multiple reasons can account for the different surgical management of patients with AGCT by different Gynecological Oncologists. First, there is an extremely low incidence of lymphovascular invasion in patients with AGCT (0-8.8 %) [19,26].…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary

Thomakos

Biliatis

Koutroumpa

et al. 2016

Arch Gynecol Obstet

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“…2d: the most common route drains through the hypogastic or obturator regions to the common iliac LNs; next, spreading along the round ligament to the inguinal LNs takes place; the last directly involves the para-aortic LNs through the ovarian vessels. [29]. Moreover, from grade 1 to 3, the incidence rate of LN metastasis increased from 4.0 to 20.0 % [30].…”

Section: Endometrial Cancermentioning

confidence: 93%

Imaging of Pelvic Lymph Nodes

et al. 2014

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Imaging evaluation to determine the status of pelvic lymph nodes has yet to attain benchmark status clinically. On one hand, pelvic lymphatic drainage is complex and varies depending on the types and locations of primary tumors. On the other hand, current imaging techniques still have the potential to improve the detection of micrometastatic lesions and differentiation between hyperplastic and malignant nodes. This article addresses the strengths and weaknesses of imaging techniques as well as specific lymphatic metastatic routes that could increase the diagnostic confidence concerning pelvic lymph nodes. Keywords Lymph node Á Pelvic Á Cancer Á Metastasis Á Imaging Á Computed tomography Á Magnetic resonance imaging This article is part of the topical collection on Urogenital Imaging.

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Lymph-node metastasis in stage I and II sex cord stromal and malignant germ cell tumours of the ovary: A systematic review

Cited by 21 publications

References 13 publications

MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1

MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1

Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary

Imaging of Pelvic Lymph Nodes

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