Lymph Node Micrometastasis: A Predictor of Early Tumor Relapse After Complete Resection of Histologically Node-Negative Esophageal Cancer

Li, Shuhai; Wang, Zhou; Liu, Xiangyan; Liu, Fan-ying; Sun, Zhao-Yi; Han, Xue

doi:10.1007/s00595-007-3548-y

Cited by 33 publications

(26 citation statements)

References 11 publications

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“…Follow-up studies consisted of physical examination, laboratory analysis, barium esophagram, ultrasound examination, computed tomography and fiberoptic esophagoscopy to detect recurrent diseases (Li et al 2007). Followup was completed in all 157 patients until May 2011, and the median follow-up period was 39 months (range: 6-73 months).…”

Section: Patients and Follow-upmentioning

confidence: 99%

USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma

Wang

2012

J Cancer Res Clin Oncol

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Section: Patients and Follow-upmentioning

confidence: 99%

USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma

Wang

2012

J Cancer Res Clin Oncol

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“…Li et al present similar observations. The author observed the appearance of micrometastases in 9.4% of examined lymph nodes but together with the feature T they constitute an independent prognostic factor in the overall 5-year survival rate of the patients [21]. Some authors point out that hidden micrometastasis should be defined as every metastasis found in classic microscopic study [14,22].…”

Section: Discussionmentioning

confidence: 99%

Lymph node micrometastases of adenocarcinoma located in gastroesophagal junction

Włodarczyk¹,

Mueller²,

Włodarczyk³

2013

pjp

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Background:The aim of this study was to evaluate the presence of micrometastases (MM) and tumor cell microinvolvement (TCM) in regional lymph nodes of patients with gastroesophageal junction adenocarcinoma. Material and methods: 61 patients with adenocarcinoma (stage N0) were included in this study. Lymph nodes removed during surgery were examined using mixed monoclonal antibodies against pan-cytokeratins (AE1/AE3). Micrometastases was defined as single neoplastic cells or infiltration with diameter below 0.5 mm but not involving the interstitium. Results: Micrometastases were found in 2 cases with adenocarcinoma type I and 4 cases with type III. Tumor cell microinvolvement was found in 2 cases of either adenocarcinoma type I or type III (according to Siewert's classification). Presence of MM did not influence survival rate. Conclusions: Despite no influence of MM presence on survival rate, MM came from adenocarcinoma type III more frequently. The presence of MM proved lack of homogeneity in the group of N0 stage and makes evaluation advantageous.

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“…[27][28][29][30] On the other hand, many reports have indicated that immunohistochemical nodal micrometastasis is a significant prognostic indicator in patients with cN0 esophageal cancer. [31][32][33] Although SN mapping in esophageal cancer is obviously more invasive than other imaging techniques, nodal micrometastasis in SN that may affect survival of the patient cannot be ignored. At present, SN biopsy is believed to detect micrometastasis more accurately and cost-effectively than other imaging procedures in patients with cN0 early esophageal cancer.…”

Section: Micrometastasis In Sentinel Nodes Of Patients With Early Esomentioning

confidence: 99%

Sentinel Node Navigation Surgery in Early-Stage Esophageal Cancer

Takeuchi¹,

Kawakubo²,

Takeda³

et al. 2012

ATCS

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The sentinel node (SN) concept has revolutionized the surgical staging of both melanoma and breast cancer over the past two decades. However, the validity of the SN hypothesis has been controversial for esophageal cancer, because SN mapping for esophageal cancer is technically complicated, and the number of early-stage esophageal cancer is very limited. Nevertheless previous studies nicely demonstrated that SN mapping may be feasible in patients with earlystage esophageal cancer. Transthoracic extended esophagectomy with three-field radical lymph node dissection has been recognized as a curative procedure for thoracic esophageal cancer in Japan. However, uniform application of this highly invasive procedure might increase the morbidity and markedly reduce the quality of life (QOL) after surgery. Although further accumulation of evidence based on multicenter clinical trials using a standard protocol is needed, SN mapping and SN navigation surgery would provide significant information to perform individualized selective lymphadenectomy which might reduce the morbidity and retain the patients' QOL. In addition, technical innovation including the development of new tracers is expected to confirm the accuracy and reliability of SN mapping in esophageal cancer.

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Lymph Node Micrometastasis: A Predictor of Early Tumor Relapse After Complete Resection of Histologically Node-Negative Esophageal Cancer

Abstract: The prevalence of LNMM in patients with pN0 ESCC was 34.4% (32/93). Thus, LNMM was significantly associated with the disease-free interval. T status and LNMM were both independent prognostic factors.

Cited by 33 publications

References 11 publications

USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma

USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma

Lymph node micrometastases of adenocarcinoma located in gastroesophagal junction

Sentinel Node Navigation Surgery in Early-Stage Esophageal Cancer

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