We investigated the location, size, and shape of cervical lymph nodes in head and neck cancer, using a 7.5-MHz ultrasound scanner. First, the different criteria for normal size were obtained for cervical lymph nodes in each region; lymph nodes greater than 9 mm in thickness in the internal jugular chain or greater than 7 mm in thickness in the submandibular and submental chains should be suspected of harboring metastatic foci. Second, meta· static nodes showed a more rounded configuration than A precise evaluation of the presence of meta· stasis to the cervical lymph nodes is mandatory in the management of head and neck malignancies. X-ray computed tomography (CT), 1 magnetic resonance imaging (MRI), and ultrasound 2 -4 have been used to evaluate lymphadenopathy in the neck. Recent reports on ultrasonography in the neck suggest its high efficiency in detecting small, nonpalpable lymphadenopathy. Although size has been used to diagnose me~ tastasis in lymph nodes, few studies have dealt with their internal structure.To determine the size and shape criteria for normal lymph nodes in each region in the neck, as well as to clarify any abnormal patterns of internal structure in metastatic lymph nodes, we conducted a correlative Received July 20, 1987, from the Departments of "Radiology, fOral Surgery. *Otolaryngology. and §Laboratory Medicine, School of Medi· cine, Shinshu University. Asahi, Matsumoto, Japan. Revised manuscript accepted for publication October 29, 1987. Address correspondence and reprint requests to Dr. F. Sakai: De· partment of Radiology, School of Medicine, Shinshu University, Asahi, Matsumoto, 390, Japan. nonmetastatic ones. Third, a comparative study of metastatic lymph nodes between the in vivo and in vitro ultrasonograms and the corresponding histopathological findings disclosed that an echogenic region in an ultrasonogram of a metastatic node was caused by coagulation necrosis, and a cystic area of liquefaction necrosis. KEY WORDS; ultrasonography, lymphadenopathy, echogenicity, size of lymph node. (/ Ultrasound Med 7: 305, 1988)