Lymphangioma-like pattern and anaplastic evolution in a case of classic Kaposi's sarcoma

Masia, Ina Maria; Mugoni, Maria Grazia; Massarelli, Giovannino; Rovasio, S; Cottoni, F

doi:10.1016/s0926-9959(97)00065-2

Cited by 6 publications

(10 citation statements)

References 8 publications

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“…Subsequently, this anaplastic pattern was frequently found in African KS 2 . Anaplastic transformation has rarely been reported in classic KS (CKS) 3–6 . The sporadic reports of this histological variant confirm its rarity in CKS, and consequently few data are available with regard to its frequency, clinical presentation and histological characteristics.…”

Section: Clinical Findings and Mitotic Index In Five Patients With Amentioning

confidence: 99%

Anaplastic transformation of classic Kaposi's sarcoma: clinicopathological study of five cases.

Satta¹,

Cossu²,

Massarelli³

et al. 2001

Br J Dermatol

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Section: Clinical Findings and Mitotic Index In Five Patients With Amentioning

confidence: 99%

Anaplastic transformation of classic Kaposi's sarcoma: clinicopathological study of five cases.

Satta¹,

Cossu²,

Massarelli³

et al. 2001

Br J Dermatol

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“…Davis et al . stated that the word ‘bullous’ is only an inaccurate clinical description that is best not used 2 . Cossu et al .…”

mentioning

confidence: 99%

Lymphangioma‐like Kaposi's sarcoma: report of four cases and review

Sánchez

Ferrufino

Bravo

et al. 2006

Acad Dermatol Venereol

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EditorKaposi's sarcoma (KS) is characterized by a wide range of cutaneous manifestations, such as macules, plaques, papules and nodules. However, some variants are only rarely observed and reported. 'Lymphangioma-like' or 'bullous KS' is very uncommon. The clinical features were first reported in 1957 by Ronchese and Kern. 1 Since then, only 21 cases have been published. We report the clinical correlation of four rare cases of lymphangioma-like KS with bulla-like lesions and review the literature.The first patient was a 65-year-old man with an 8-year history of pain and pruritus on the upper and lower extremities who presented with bulla-like lesions on both arms. These lesions varied in size from 0.5 to 2 cm in diameter. The second patient was an 89-year-old indigenous woman with a 1-month history of pain and oedema who presented with multiple nearly confluent violaceous nodules on her legs. Nodules varied in size from 0.5 to 1 cm in diameter. She also presented two bulla-like lesions on her left ankle. The third patient was a 61-year-old man with a 1-year history of pain and oedema who presented with multiple confluent brownish nodules and plaques on the lower extremities. Nodules varied in size from 0.5 to 1.5 cm in diameter. In these three patients, no lymphadenomegaly was clinically detectable, results of blood tests were within normal limits, and HIV serology proved negative. The fourth patient was a 36-year-old woman with a 5-year history of AIDS who presented with multiple violaceous plaques and nodules on her legs, and macules on her soft palate. Seven months before this she had been diagnosed with KS on the basis of her clinical presentation and histopathological features. At that time her lower extremities were treated with external radiation. Two months later, she experienced a rapid onset of bulla-like lesions on her right leg ( fig. 1). She was treated with systemic chemotherapy with no apparent response. The lesions had a tense consistency and were easily friable. Her CD4 count was less than 10 cells/mL and the viral load was 100 000 copies/mL. The patient died about 2 weeks later. fig. 1 Multiple confluent nodules and bulla-like lesions on the right foot.

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“…Lymphangioma‐like pattern resembling lymphangioendothelioma has to be recognized 15 . Anaplastic variant of KS must be distinguished from all of the common solid spindle cell malignant tumours, such as squamous cell carcinoma, amelanotic melanoma and fibrosarcoma 16 . Immunohistochemical detection of CD31, CD34 antigens, FVIII‐RAg and sialic acid expression are important for the correct diagnosis of KS (fig.…”

Section: Histologymentioning

confidence: 99%

“…There is no standard therapy for the classic KS. After surgical excision local recurrence is often seen and chemotherapy with vinblastin or bleomycin is not considered very effective 16,19 . Radiation therapy provides excellent palliation with minimal side‐effects 20 and interferon α and IgG treatment can bring about regression 21,19,22 …”

Section: Therapymentioning

confidence: 99%

Kaposi's sarcoma – still an enigma

Babál

2003

Acad Dermatol Venereol

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Kaposi's sarcoma (KS) is an unusual neoplasm that has proved to be an enigma in many ways since its original description in 1872. KS, a vascular tumour that is otherwise rare, is at present the most common neoplasm in patients with AIDS. The lesions contain spindle cells that share features with endothelial cells and smooth muscle cells and are in all likelihood primitive mesenchymal cells that can form vascular channels. These cells are monoclonal in origin indicating therefore that KS is a neoplasm. The presence of a novel type of human herpes virus, KS herpesvirus (KSHV) also called human herpesvirus type 8 (HHV8) in KS lesions support a viral ethiology. KS may be mistaken in the skin for an inflammatory or other lesion, thus skin biopsy is important for correct diagnosis, with the use of immunohistochemistry or molecular biology if needed. Radiation or interferon alpha dominate in the therapeutic approaches.

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Lymphangioma-like pattern and anaplastic evolution in a case of classic Kaposi's sarcoma

Cited by 6 publications

References 8 publications

Anaplastic transformation of classic Kaposi's sarcoma: clinicopathological study of five cases.

Anaplastic transformation of classic Kaposi's sarcoma: clinicopathological study of five cases.

Lymphangioma‐like Kaposi's sarcoma: report of four cases and review

Kaposi's sarcoma – still an enigma

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