Lymphatic and hematopoietic cancer in teachers

Baker, P; Inskip, Hazel; Coggon, David

doi:10.5271/sjweh.377

Cited by 25 publications

(17 citation statements)

References 30 publications

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“…The RRs showed considerable heterogeneity between studies. The combined RR estimated using the random-effects model was 1.47 (95% CI, 1.34-1.61), showing that the inclusion of the more recent studies increased the estimate for the summary RR compared with the meta-analysis by Baker et al (3). No statistically significant differences were found between teachers in primary or secondary education (6,17), nor between teachers in theoretical subjects, teachers of music, arts and crafts, or headmasters and principals (5).…”

Section: Methodsmentioning

confidence: 83%

Occupation and the Risk of Non-Hodgkin Lymphoma

Boffetta¹,

Vocht²

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Although thus far no occupational agents have been classified as established causes of non-Hodgkin lymphoma (NHL), employment as a farmer, teacher, dry cleaner, meat worker, printer, or wood worker has been associated with elevated risk in the peer-reviewed literature. We conducted several meta-analyses to assess risk in these occupations and industries from articles published in MEDLINE up to August 1, 2006. The summary risk estimates suggest a homogeneous excess risk for NHL among workers in the printing industry [relative risk (RR), 1.86; 95% confidence interval (95% CI), 1.37-2.52] and wood workers (RR, 1.15; 95% CI, 1.00-1.31). Considerable heterogeneity but elevated risks were found for farmers (RR, 1.11; 95% CI, 1.05-1.17), especially in animal husbandry (RR, 1.31; 95% CI, 1.08-1.60), and teaching (RR, 1.47; 95% CI, 1.34-1.61). An increased risk was absent for employment in the meat processing industry (RR, 0.99; 95% CI, 0.77-1.29). These results suggest that although excess risk is found for employment in the printing industry, wood processing industry, teaching, and farming, it is unlikely that occupation represents a major risk factor for NHL in most populations. At present, no conclusive evidence of causal relations between occupations and increased NHL risk exists; this can be ascribed to methodologic problems in studying the link between NHL risk and occupation, including heterogeneity of disease and exposure circumstances and low statistical power. Implementing stateof-the-art exposure assessment technologies, including biomarker-based assessment, and aiming to identify susceptible subgroups can increase the statistical power enough to analyze etiologically relevant NHL subtypes and provide clues on possible causal agents in future studies. These goals can be best attained within the framework of large-scale, international collaborative projects. (Cancer Epidemiol Biomarkers Prev 2007;16(3):369 -72)

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Section: Methodsmentioning

confidence: 83%

Occupation and the Risk of Non-Hodgkin Lymphoma

Boffetta¹,

Vocht²

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Some studies support a causal association between occupational exposure to viruses and NHL, especially among teachers [80] and breeders (Table 6) [31, 76,81]. Two caseÀcontrol studies found a positive association between working with animals and NHL [79,82].…”

Section: ) [61à65]mentioning

confidence: 97%

“…Infectious agents, especially viruses, are also suspected of causing MM mortality: two studies found elevated mortality from MM among teachers (Table 10) [80]. A nested caseÀcontrol study in a cohort of meat industry workers also showed an increased risk of MM among male supermarket cutters [88].…”

Section: ) [61à65]mentioning

confidence: 97%

Occupational Exposures and Haematological Malignancies: Overview on Human Recent Data

Descatha

Jenabian

Conso

et al. 2005

Cancer Causes Control

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“…Findings from a meta-analysis of 14 studies (RR range: 0.31-3.60) indicated a significantly elevated relative risk of NHL among schoolteachers (meta-RR 5 1.36, 95% CI: 1.13-1.62); however, the authors suggested that results may have been affected by publication bias. 262 A significantly elevated proportionate cancer mortality ratio (PCMR) was found for childcare workers in a census study of women in US occupations (PCMR 5 1.52, 95% CI: 1.12-2.03). 268 Although specific occupational exposures have not been identified, exposure during adulthood to common childhood infections has been hypothesized to play a role.…”

Section: Occupational and Environmental Chemical Exposurementioning

confidence: 99%