Lymphatic vessels and Kurloff cells in the thymus of estradiol-treated guinea pigs

Sandberg, Göran; Hagelin, Margareta

doi:10.1007/bf00318459

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…Particulate materials injected intraperito- neally may be taken up by macrophages and transmitted via lymphatic vessels to the mediastinum and thence into thymic parenchyma (Kolsch, 1968;Eggli et al, 1986). In addition, the recent study of the distribution of the lymphatic vessel and Kurloff cells in the thymus of estradiol-treated guinea pigs suggests the existence of an afferent migratory pathway (Sandberg and Hagelin, 1990).…”

Section: Lymphocyte Migrationmentioning

confidence: 99%

Thymic microvascular system

Kato

1997

Microsc. Res. Tech.

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Morphological studies of the microcirculatory system in the thymus were reviewed in regards to methodology and structural organization of blood and lymphatic vessels. The blood capillaries and postcapillary venules (PCVs) in the thymus are characterized by a double‐walled structure. These vessels are surrounded more or less by perivascular spaces (PVSs) containing many lymphocytes. This space is delimited on the one side by abluminal surface of the vascular endothelium and on the other side by cytoplasmic processes of epithelial reticular cells. There are interruptions or gaps on the outer epithelial reticular layer. The lymphatic vessels can be distinguished histochemically from blood vessels based on strong 5′‐nucleotidase (5′‐Nase) activity. The 5′‐Nase‐positive lymphatic vessels were seen predominantly in the capsule and interlobular connective tissue but sometimes in the immediate vicinity of the PVS around the PCV, when a discrete opening in the lymphatic wall next to the PVS was found. Thus, it may be regarded as an initial part of lymphatics closely associated with the PVS, suggesting a possible route for lymphocyte efflux into the lymphatic vessel from the PVS. The endothelial cells of lymphatic vessels as well as PCVs are often infiltrated by lymphocytes, particularly more heavily during acute involution of the thymus. These images represent the migration of lymphocytes into the blood or lymphatic microcirculation. Microsc. Res. Tech. 38:287–299, 1997. © 1997 Wiley‐Liss, Inc.

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Section: Lymphocyte Migrationmentioning

confidence: 99%

Thymic microvascular system

Kato

1997

Microsc. Res. Tech.

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“…Several reports of the presence of estrogen receptors in the thymic epithelial cells suggest that thymus is a target organ for estrogen [20]. Dynamic remodelling of its structure occurs after estradiol treatment and varying estrogen levels can alter thymic hormone output [21]. Estrogen treatment led to the induction of a novel subpopulation of regulatory cells, CD45dim VLA-4 + in spleen and CNS in case of EAE, which also occurs naturally in pregnant mice.…”

Section: Estrogen Regulated Immune Signalling Estrogen Modulates Tregmentioning

confidence: 99%

Forbearance of the Immune System during pregnancy: Fetal parasite takes an estrogenic way!

Laloraya¹,

Padmanabhan²

2016

Reproductive Immunol Open Acc

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Understanding the mission of managing the genetically diverging fetus as "transitory self" by the mother during pregnancy is vital in detailing the state of immunological tolerance. Hormones dictate the whole event and helps in enrolling, differentiating and altering the functions of immune cells. Estrogen the decisive hormone during embryo implantation as it activates embryo for adhesion and determines the window of uterine receptivity, along with progesterone exerts control over differentiating endometrial and immune cells. This review focuses on how estrogen modulates various immune cells to develop a uterine milieu conducive for the growth of the fetus.

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Glycoconjugates with Neu5Ac(?2,6)Gal(?1,4)GlcNAc sequences: a selective lectin-histochemical property of Kurloff cells in guinea pig thymus

et al. 1993

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The Kurloff cell (KC), a natural killer lymphocyte, contains a large (10-microns diameter) periodic acid-Schiff (PAS)-positive lysosome-like inclusion body called the Kurloff body (KB), which exhibits strong acid phosphatase activity. The presence of Sambucus nigra agglutinin (SNA)-reactive Neu5Ac(alpha 2,6)-D-Gal/Gal-NAc(beta 1,4)GlcNAc oligosaccharide sequences and the absence of the corresponding Neu5Ac(alpha 2,3) Maackia amurensis agglutinin (MAA)-reactive sequence in the major 35-kDa N-glycosylproteins of the complex or hybrid type extracted from purified KC were established by Western-lectin-blotting of cytosolic extracts from purified KC. Moreover, these SNA-reactive sequences, or at least part of them, were shown to be borne by sialidase-sensitive KC acid isophosphatases. Thymic sections rich in KC, from estrogenized guinea pigs were examined by affino-histochemistry with these sialic acid-reactive lectins. The SNA-reactivity of thymic sections was quasi-exclusively confined to KC clusters, whereas the whole thymic section was negative for MAA. KC were not SNA-reactive following preincubation and incubation with 200 mM lactose. When submitted to enzymatic or mild chemical desialylation processes, the SNA-reactivity of the KC clusters was enhanced. The SNA-reactivity of KC clusters was completely abolished following prolonged chemical desialylation, whereas the PAS-positivity of KB remained unchanged. Even after a prolonged sialidase treatment, this SNA-reactivity was only reduced. Moreover, after both these desialylation processes, KC developed a heavier Ricinus communis agglutinin-reactivity, thus confirming the presence of penultimate Gal residues in their abundant SNA-reactive oligosaccharide sequences Neu5Ac(alpha 2,6)Gal(beta 1,4)GlcNAc. Such a selective lectin histochemical property provides a marker for detecting KC.

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Lymphatic vessels and Kurloff cells in the thymus of estradiol-treated guinea pigs

Cited by 8 publications

References 7 publications

Thymic microvascular system

Thymic microvascular system

Forbearance of the Immune System during pregnancy: Fetal parasite takes an estrogenic way!

Glycoconjugates with Neu5Ac(?2,6)Gal(?1,4)GlcNAc sequences: a selective lectin-histochemical property of Kurloff cells in guinea pig thymus

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