LYMPHEDEMA is a chronic disease characterized by an abnormal accumulation of interstitial lymph. Despite current research, it remains a disease entity for which there is no medical or surgical cure. Even the pathogenesis of this disease in many cases remains unclear. The first article to this series discussed the anatomy, etiology, pathogenesis, and classification of lymphedema. The clinical signs, diagnostic procedures, and medical and surgical management of patients with lymphedema will be discussed.