Lymphocyte access to lymphoma is impaired by high endothelial venule regression

Menzel, Lutz; Zschummel, Maria; Crowley, Tadhg; Franke, Vedran; Grau, Michael; Ulbricht, Carolin; Hauser, Anja E.; Siffrin, Volker; Bajénoff, Marc; Acton, Sophie E.; Akalin, Altuna; Lenz, Georg; Willimsky, Gerald; Höpken, Uta E.; Rehm, Armin

doi:10.1016/j.celrep.2021.109878

Cited by 10 publications

(9 citation statements)

References 68 publications

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“… 20 , 22 , 48 Beyond that, growing attention has been recently paid to HEVs that are specialized vessels that allow lymphocyte recirculation through the TDLNs and are indispensable for effective ICI therapy. 19 , 49 , 50 In this study, we discovered that the number and expression (MFI) of HEVs within the TDLNs+ were drastically reduced, compared with TDLNs- ( Figure 6 a, 6 b). Besides, HEVs within TDLNs are malformed.…”

Section: Discussionmentioning

confidence: 65%

Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors

Yang¹,

Sun²,

Ma³

et al. 2022

eBioMedicine

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Section: Discussionmentioning

confidence: 65%

Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors

Yang¹,

Sun²,

Ma³

et al. 2022

eBioMedicine

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“…We took advantage of already published scRNASeq data of BEC from the Eµ- Myc mouse model of aggressive lymphoma compared to control mice. 45 Seven statistically significant interactions were identified between ligands expressed by BEC and receptors expressed by Mo&Mac, in either the lymphoma context, the reactive context, or both (Figure 5A). Lymphoma BEC were predicted to interact with Mo&Mac from DLBCL via AnnexinA1 (ANXA1) binding to the formyl-peptide receptors FPR1 or FPR2, an interaction not found in reactive context.…”

Section: Resultsmentioning

confidence: 99%

“…(B) ANXA1 expression on normal and tumor BEC 45 and FPR1 and FPR2 expression levels on DLBCL Mo&Mac clusters (left). Mann-Whitney, *p < 0.05.…”

Section: Resultsmentioning

confidence: 99%

Single-cell profiling identifies clinically relevant interactions between tumor associated macrophages and blood endothelial cells in diffuse large B cell lymphoma

Ferrant

Gallou

Padonou

et al. 2022

Preprint

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Diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) are the two most common B-cell lymphomas and are characterized by a dynamic crosstalk between tumor B cells and a heterogeneous tumor-supportive microenvironment, including immune, endothelial, and stromal components. Although their impact on the pathogenesis and prognosis of B-cell lymphoma has been acknowledged for years, tumor-associated macrophages (TAM) have not been extensively explored in DLBCL and FL. Herein, we investigate mononuclear phagocytes (MNP) heterogeneity at the single cell level and their potential co-regulation with the stromal and endothelial compartments in B-cell lymphoma lymph nodes compared to reactive secondary lymphoid organs, using a combination of mass cytometry, single cell RNA sequencing, and in silico approaches. We reveal a co-regulation between TAM and blood endothelial cells (BEC) in lymphoma. Moreover, we identify a specific interaction between Annexin A1 (ANXA1)-expressing BEC and formyl-peptide receptors (FPR1/2)-expressing monocytes/macrophages in DLBCL, which we confirm in situ by multiplex immunofluorescence and imaging mass cytometry. This crosstalk is associated to an immunosuppressive tumor microenvironment and an adverse prognosis in DLBCL.

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“…These selectively overexpress JAMB and JAMC and are particularly important for lymphocyte transmigration into lymph nodes [10,37]. Tumors may cause HEV regression, thus reducing IC tumor infiltration and the anti-tumoral immune response [74]. HEV are entry sites for IC that generate tertiary lymphoid structures which participate in immune suppressive responses [75].…”

Section: High Endothelial Venules (Hev) and Leukocyte Extravasation I...mentioning

confidence: 99%

Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response

Welsh

2022

IJMS

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The vasculature plays a major role in regulating the tumor immune cell response although the underlying mechanisms explaining such effects remain poorly understood. This review discusses current knowledge on known vascular functions with a viewpoint on how they may yield distinct immune responses. The vasculature might directly influence selective immune cell infiltration into tumors by its cell surface expression of cell adhesion molecules, expression of cytokines, cell junction properties, focal adhesions, cytoskeleton and functional capacity. This will alter the tumor microenvironment and unleash a plethora of responses that will influence the tumor’s immune status. Despite our current knowledge of numerous mechanisms operating, the field is underexplored in that few functions providing a high degree of specificity have yet been provided in relation to the enormous divergence of responses apparent in human cancers. Further exploration of this field is much warranted.

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Lymphocyte access to lymphoma is impaired by high endothelial venule regression

Cited by 10 publications

References 68 publications

Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors

Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors

Single-cell profiling identifies clinically relevant interactions between tumor associated macrophages and blood endothelial cells in diffuse large B cell lymphoma

Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response

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