Lymphocyte function and virus infections.

Denman, A. M.

doi:10.1136/jcp.s3-13.1.39

Cited by 15 publications

(9 citation statements)

References 29 publications

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“…95 In fact, even in patients with relatively mild illness, lymphopenia is a common and characteristic feature of COVID-19, suggesting that the adaptive immune response is blunted and may be delayed or insufficient. 27,29,30,32,43,44,52,87,88 One possible explanation is that, like a number of other viruses, 96 SARS-CoV2 may directly infect lymphocytes. SARS-CoV2 relies on angiotensin-converting enzyme 2 (ACE2)…”

Section: Discussionmentioning

confidence: 99%

Association between markers of immune response at hospital admission and COVID‐19 disease severity and mortality: A meta‐analysis and meta‐regression

Khinda

Janjua

Cheng³

et al. 2020

Journal of Medical Virology

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To determine the utility of admission laboratory markers in the assessment and prognostication of COVID‐19, a systematic review and meta‐analysis was conducted on the association between admission laboratory values in hospitalized COVID‐19 patients and subsequent disease severity and mortality. Searches were conducted in MEDLINE, Pubmed, Embase, and the WHO Global Research Database from Dec 1, 2019 to May 1, 2020 for relevant articles. A random effects meta‐analysis was used to calculate the weighted mean difference (WMD) and 95% confidence interval (95% CI) for each of 27 laboratory markers. The impact of age and sex on WMDs was estimated using meta‐regression techniques for 11 markers. In total, 64 studies met inclusion criteria. The most marked WMDs were for neutrophils (ANC) at 3.82x10 9 /L (2.76, 4.87), lymphocytes (ALC) at ‐0.34x10 9 /L (‐0.45, ‐0.23), interleukin‐6 (IL‐6) at 32.59pg/mL (23.99, 41.19), ferritin at 814.14ng/mL (551.48, 1076.81), C‐reactive protein (CRP) at 66.11mg/L (52.16, 80.06), Ddimer at 5.74mg/L (3.91, 7.58), LDH at 232.41U/L (178.31, 286.52), and high sensitivity troponin I at 90.47pg/mL (47.79, 133.14) when comparing fatal to non‐fatal cases. Similar trends were observed comparing severe to non‐severe groups. There were no statistically significant associations between age or sex and WMD for any of the markers included in the meta‐regression. The results highlight that hyperinflammation, blunted adaptive immune response, and intravascular coagulation play key roles in the pathogenesis of COVID‐19. Markers of these processes are good candidates to identify patients for early intervention and, importantly, are likely reliable regardless of age or sex in adult patients. This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

Association between markers of immune response at hospital admission and COVID‐19 disease severity and mortality: A meta‐analysis and meta‐regression

Khinda

Janjua

Cheng³

et al. 2020

Journal of Medical Virology

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“…Lymphocytes mean values were within the normal range, though it was expected to rise during many viral infections [ 21 , 22 ]. This is in contrast to a previous research finding where there was a significant increase in both the percentage and the concentration of total lymphocytes in dengue fever, which was due to a marked increase in both the percentage and the number of atypical lymphocytes, where normal lymphocytes were essentially unchanged [ 19 ].…”

Section: Main Textmentioning

confidence: 99%

Value of peripheral blood count for dengue severity prediction

et al. 2018

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ObjectiveThis retrospective study was conducted in 2017 with the objective of evaluating the value of acute phase peripheral blood parameters in predicting dengue haemorrhagic fever (DHF). Patients, who were admitted to Teaching Hospital Peradeniya between January and August 2017 due to dengue illness, were recruited into this study.ResultsA total of 515 patients participated in the study. Among them, 333 were DHF patients while 182 patients were managed as DF. There was a significant difference in mean values of platelets and haemoglobin observed during acute phase in non-leakers compared to the patients who progressed to DHF, while no significant difference was observed for white blood cells, neutrophils, lymphocytes and haematocrit values. A significantly higher mean value was observed in white blood cells and hemoglobin in leakers compared to non-leakers during day 5. Mean day 5 platelet value was significantly lower among leakers compared to non-leakers but no significant difference between haematocrit, neutrophil and lymphocyte values were observed. ROC curve performed for acute phase platelet values and haemoglobin values to gain a predictive value for female and male DHF patients and cut off values with high sensitivity and specificity to predict DHF could be obtained for the platelet count.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3505-4) contains supplementary material, which is available to authorized users.

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“…For example, it was found that the sialic acid content of rheumatoid factor IgG and IgM is lower than that of normal IgG and IgM (Duc Dodon & Quash, 1981). This observation and the results reported here imply that the modulation of enzyme activities in B lymphocytes in response to an exogenous aggression may lead to disturbances in the structure and antigenic properties of immunoglobulins and thus interfere with the functions of these cells (Denman, 1979;Proffitt, 1979).…”

Section: Discussionmentioning

confidence: 78%

Secretion of Immunoglobulins by Human Lymphocytes after Infection with Influenza Virus

Dodon¹,

Gazzolo²,

Quash³

et al. 1982

Journal of General Virology

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The biosynthesis of IgM by the Epstein-Barr virus-negative RAMOS lymphoblastoid cell line infected with an influenza A virus, fowl plague virus Dobson strain (FPV-B), was investigated. The results show that FPV infection of RAMOS cells slightly inhibited overall cellular protein synthesis only at 24 h after infection, despite the synthesis of FPV-specific proteins. However, even at this time, the synthesis and secretion of IgM were not affected by virus infection. Secreted IgM contained a reduced amount of sialic acid. The quantity of the asialylated IgM increased proportionally to the amount of enzymically active neuraminidase, suggesting that the asialylation of IgM is due to the action of virus neuraminidase. No such asialylated IgM was observed in RAMOS cells infected with measles virus, which does not possess neuraminidase. These results, together with a previous observation of ours that asialylated immunoglobulins acquire an altered antigenicity, suggest that the modulation of enzyme activities in B lymphocytes in response to an exogenous aggression may lead to disturbances in the structure and in the antigenic properties of immunoglobulins.

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Lymphocyte function and virus infections.

Cited by 15 publications

References 29 publications

Association between markers of immune response at hospital admission and COVID‐19 disease severity and mortality: A meta‐analysis and meta‐regression

Association between markers of immune response at hospital admission and COVID‐19 disease severity and mortality: A meta‐analysis and meta‐regression

Value of peripheral blood count for dengue severity prediction

Secretion of Immunoglobulins by Human Lymphocytes after Infection with Influenza Virus

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