Encyclopedic Reference of Immunotoxicology
DOI: 10.1007/3-540-27806-0_920
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Lymphocyte Proliferation

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Cited by 5 publications
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“…Whereas, in studies by Nesse et al, 2002 and Kurcz et al, 1988 [ 23 , 24 ], the stimulation took only 2 h and 48 h, respectively. This may be too short for proper cell division, because in humans, peak mitogenic responses are shown after at least 72 h or even 4–5 days culturing [ 25 ]. Furthermore, as was mentioned earlier in our study the exercise did not last longer than 1 h.…”
Section: Discussionmentioning
confidence: 99%
“…Whereas, in studies by Nesse et al, 2002 and Kurcz et al, 1988 [ 23 , 24 ], the stimulation took only 2 h and 48 h, respectively. This may be too short for proper cell division, because in humans, peak mitogenic responses are shown after at least 72 h or even 4–5 days culturing [ 25 ]. Furthermore, as was mentioned earlier in our study the exercise did not last longer than 1 h.…”
Section: Discussionmentioning
confidence: 99%
“…In this context, the multiple molecular cell‐cycle alterations that we identified suggest that SARS‐CoV‐2 mainly affects human leukocytes, as indicated by our integrative analyses of proteomic, bulk RNAseq, and scRNAseq data. Based on the scRNAseq data, it is likely that the cell‐cycle alterations affect predominately B, T, and NK cells, which is expected since proliferation is a fundamental response characteristic for lymphocytes during antigenic stimulation 41 . However, the pathologic effect of SARS‐CoV‐2 infection results in multiple cellular alterations not only in lymphocytes but also monocytes, eosinophils, and basophils, while neutrophil counts are elevated, 42 indicating that the changes of cell cycle‐associated genes and proteins may not be limited to the peripheral blood.…”
Section: Discussionmentioning
confidence: 99%
“…Based on the scRNAseq data, it is likely that the cell‐cycle alterations affect predominately B, T, and NK cells, which is expected since proliferation is a fundamental response characteristic for lymphocytes during antigenic stimulation. 41 However, the pathologic effect of SARS‐CoV‐2 infection results in multiple cellular alterations not only in lymphocytes but also monocytes, eosinophils, and basophils, while neutrophil counts are elevated, 42 indicating that the changes of cell cycle‐associated genes and proteins may not be limited to the peripheral blood. Wang et al 43 reported that bone marrow hematopoietic stem cells from severe COVID‐19 patients were dysregulated, prone to apoptosis, and tended to arrest in G1, resulting in diminished lymphocyte progenitors while immature myeloid progenitors accumulated.…”
Section: Discussionmentioning
confidence: 99%
“…After the stimulation of splenocytes, lymphocyte proliferation was observed in mice that had been instilled with fungal extract and native Alt a 1. Lymphocyte proliferation is a key feature of the lymphocyte response to antigenic stimulation, leading to an effective immune response to antigen [73].…”
Section: Discussionmentioning
confidence: 99%