Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast

Abstract

In addition to B lymphocyte subsets, T lymphocyte subsets could be involved differently in SLL. CD4 lymphocytes may have a pivotal role in recruiting other subsets to the inflamed site, and triggered the cascade of inflammatory changes resulting in fibrosis.

Hematologic Malignancies of the Breast: A Contemporary Series Investigating Incidence, Presentation, Accuracy of Diagnosis on Core Needle Biopsy, and Hormone Receptor Expression

“…The lymphocytes associated with lymphocytic mastopathy are predominantly B cells. 15,16 Although lymphocytic mastopathy is often associated with diabetes or autoimmune thyroid disease, 9 of the 25 women (36%) did not have such a history. In addition, autoimmune disease can also be associated with lymphoma.…”

Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis

“…For example, experience from colon cancer suggests that lymphocyte subsets at the invasive edge of tumors are more relevant for prognosis than the central tumor mass [14]. In this regard, our approach has the potential to support improvements of prognostic precision in the emerging era of oncoimmunology, for example, to evaluate inflammation close to benign precursor lesions [16,18,21,6,26] or in preexisting glandular tissue adjacent to cancer areas of small early-stage tumors, where tumor is frequently closely related to non-neoplastic preexisting tissue.…”

Diabetic mastopathy: A rare clinicopathologic entity with considerable autoimmune potential

“…Diabetic mastopathy, also termed sclerosing lymphocytic mastopathy, fibrous mastopathy or lymphocytic lobulitis of the breast, is a rare benign entity that accounts for less than 1% of all benign breast lesions [1] , [2] . Despite the benign nature of the condition, it has some clinical and diagnostic features resembling malignancy, thus, it is usually associated with several diagnostic difficulties [3] . Fibrous mastopathy was previously linked to type 1 diabetes mellitus (T1DM), which was considered the sole causative factor, however, further hypotheses then suggested the multifactorial etiology, including the contribution of autoimmunity to the pathogenesis [4] , [5] .…”