Lymphocyte subsets in schizophrenic disorders

Masserini, C; Vita, Antonio; Basile, Roberto; R, Morselli; Boato, P.; Peruzzi, Cinzia; Pugnetti, Luigi; Ferrante, Pasquale; Cazzullo, C. L.

doi:10.1016/0920-9964(90)90008-u

Cited by 48 publications

(13 citation statements)

References 18 publications

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“…As reported in the majority of the other studies we found no change in the number of T lymphocytes [15][16][17][18][19][20]. The numbers of activated T cells and T cells carrying the soluble IL-2 recpetor in schizophrenic patients were within normal limits.…”

Section: Discussionsupporting

confidence: 62%

“…Nyland et al [10] showed a decreased number of T lymphocytes in acute but not in chronic schizophrenics. An elevated number of T cells was reported by two groups [11][12][13][14] while others (including ours) demonstrated no change in T cell number [15][16][17][18][19][20]. Inhomogenuous results have been reported concerning several T lymphocyte subtypes, B lymphocytes and natural killer cells (NK cells).…”

Section: Introductionmentioning

confidence: 70%

“…Henneberg et al [11] observed a tendency towards an increased T suppressor cell number, Masserini et al [16] demonstrated unchanged CD-8-positive cell numbers in medicated schizophrenic patients but increased numbers in drug-free patients while Ackenheil et al [12] observed a higher number in medicated schizophrenics.…”

Section: Discussionmentioning

confidence: 99%

“…B lymphocytes in medicated patients were reported to be either unchanged [16,29] or elevated ( [58] in 30% of the Table 3 patients) [60]. In unmedicated schizophrenics unchanged [29] as well as elevated [16] numbers were found. We showed an increased relative number of B lymphocytes while the absolute number was within normal limits.…”

Section: Discussionmentioning

confidence: 99%

“…Müller et al [14] in 1993 reproduced their 1991 findings with respect to the absolute CD-4-positive cell number but not regarding the relative number. Others were unable to demonstrate differences in the number of T helper cells in both unmedicated [15][16][17]53] and medicated schizophrenic patients [16,[18][19][20].…”

Section: Discussionmentioning

confidence: 99%

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Immunological Dysfunction in Schizophrenia: A Systematic Approach

Rothermundt¹,

Arolt²,

Weitzsch³

et al. 1998

Neuropsychobiology

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Background: In the present study, immunological alterations were investigated as one possible factor contributing towards the pathogenesis of schizophrenia. Specifically cellular changes, deviating cytokine production and interfering variables were studied in order to improve our understanding of how these factors interact. Method: 44 acutely ill schizophrenics were compared with matched healthy controls. Cell numbers were determined by flow cytometry and cytokine production by whole blood assay and ELISA. A criss-cross technique was employed for the assessment of interfering serum factors. Results: Cell counts for leukocytes, lymphocytes, pan T cells, activated T cells and the absolute B cell count of the schizophrenic patients were all within normal limits. The absolute and relative monocyte counts, the number of IL-2 receptor carrying T cells and the relative B cell count were slightly elevated. IL-2 and IFN-γ production were increased while IL-10 production, the sIL-2R and cortisol levels remained unchanged. No interfering serum factors were detected. Conclusion: The deficient production of TH-1 cytokines in schizophrenia is not due either to a changed number of immunocompetent cells or to a counterregulation of the TH-2 cytokine IL-10. Serum factors in in vitro testing are not responsible for the deficient cytokine production.

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