Lymphocyte Transformation Induced by Inorganic and Organic Mercury

Caron, Gersende; Poutala, S.; Provost, Thomas T.

doi:10.1159/000230222

Cited by 79 publications

(27 citation statements)

References 6 publications

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“…(13) 40 (17) 15 (12) 46 (14) 32 (13) 34 (17) 7 (2) 12 (6) 3 (2) * High background value but few blasts. in vitro [15,16]. In contrast to the influence of HgCl 2 on mouse lymphocytes, lymphocyte reactivity of human cells in vitro seems not to be dependent on the MHC haplotype, since cell proliferation is induced in MNC from almost all individuals [20].…”

Section: Dependence Of Adherent Cells For Hgcl 2 -Induced Reactivitymentioning

confidence: 99%

“…It is shown that both CD4 þ T cells and adherent cells are required for activation [14]. The mitogenic property of HgCl 2 has also been demonstrated on human lymphocytes in vitro [15][16][17]. In addition, mercury may interfere with mitogen (phytohaemagglutinin (PHA) and pokeweed mitogen (PWM))-induced lymphocyte reactivity, since the proliferation response is reduced in HgCl 2 -pretreated cultures [18].…”

Section: Introductionmentioning

confidence: 99%

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In vitro effects of mercuric chloride (HgCl2) on human mononuclear cells

Loftenius

Ekstrand

Möller

1997

Clinical and Experimental Immunology

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Due to the release of the toxic compounds of mercury from amalgam fillings, dental amalgam has been questioned as an adequate restoration material for tooth fillings. HgCl2 has been found to be mitogenic for human blood lymphocytes in vitro. However, activation required much higher concentrations than are ever found in vivo. This study has been initiated to evaluate further the influence of HgCl2 on human immunocompetent cells in vitro. It is found that HgCl2 in a narrow concentration range has the ability to preferentially stimulate the CD4+ T cell subset to blast transformation and DNA synthesis. The reaction, when monitored during days 2–6, is maximal at day 6, and most blasts express the IL‐2 receptor (IL‐2R), indicating in vitro activation. The CD8+ T cell subset is not affected to the same extent. In addition, HgCl2‐induced lymphocyte reactivity is dependent on accessory cells, i.e. CD14+ cells.

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Section: Dependence Of Adherent Cells For Hgcl 2 -Induced Reactivitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro effects of mercuric chloride (HgCl2) on human mononuclear cells

Loftenius

Ekstrand

Möller

1997

Clinical and Experimental Immunology

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“…It could modify some autologous determi nants, rendering them autoantigenic. Mercury could also act as a polyclonal lymphocyte activator as it has been shown that HgCla induced a blastic transformation in vitro [3], Whatever the mechanism involved, it is clear from pre vious studies that there is a genetically determined sus ceptibility [4], BN rats develop anti-GBM antibodies though Lewis rats do not develop any immune-typeGN [4]. A similar susceptibility is quite likely to occur in man.…”

Section: Discussionmentioning

confidence: 99%

Immune-Type Glomerulonephritis Induced in the Brown-Norway Rat with Mercury-Containing Pharmaceutical Products

Druet¹,

Teychenne²,

Mandet³

et al. 1981

Nephron

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It has been shown that Brown-Norway rats develop an immune-type glomerulonephritis after treatment with various mercury-containing drugs. Anti-GBM antibodies were involved, at least in some animals. This glomerulonephritis induced a proteinuria. Strong evidence is given, suggesting that most mercury compounds, some of which, such as mercurial antiseptics, are widely used, could induce an immune-type glomerulonephritis. The question therefore arises, whether these drugs can be used any longer.

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“…Bereits in den 70cr Jahren wurde über die metallinduzierte Lymphozytensensibilisierung nach Kontakt mit Metallsalzen in vitro mit nachfolgender Transformation und Proliferation berichtet [35,36] tiven Anregungen bei der Korrektur des Manuskriptes.…”

Section: Lymphozytensensibilisierungstests In Vitrounclassified

Zahnlegierungen: Elektrochemische und biologische Materialprüfung

Ionescu¹

1996

Complement Med Res

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Die potentiellen gesundheitlichen Risiken verschiedener Dentallegierungen und Amalgame sind auf multifaktorielle Ursachen zurÜckzufÜhren. Die Freisetzung einzelner Metallkomponenten in situ wird von dem Korrosionsverhalten, von der Phasentransformation und von der Abrasion der verwendeten Legierung als auch von dem pH-Wert, der Temperatur, dem mikrobiellen Belag sowie der Zusammensetzung des Speichels und der Nahrung bestimmt. Prozesse, die zu lokalen oder Fernnebenwirkungen fÜhren kÖnnen, lassen sich durch entsprechende Korrosions-, Mobilisations- und BiokompatibilitÄtstests wie die Epikutan-, Lymphozytensensibilisierungsoder ZelltoxizitÄtsuntersuchungen feststellen und durch die richtige Materialauswahl vermeiden.

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Lymphocyte Transformation Induced by Inorganic and Organic Mercury

Cited by 79 publications

References 6 publications

In vitro effects of mercuric chloride (HgCl2) on human mononuclear cells

In vitro effects of mercuric chloride (HgCl2) on human mononuclear cells

Immune-Type Glomerulonephritis Induced in the Brown-Norway Rat with Mercury-Containing Pharmaceutical Products

Zahnlegierungen: Elektrochemische und biologische Materialprüfung

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