Lymphocytes in rheumatoid and nonrheumatoid synovial fluids: Nonspecificity of high T-cell and low B-cell percentages

Putte, L. B. A. Van De; Meijer, C. J. L. M.; Lafeber, G. J. M.; Kleinjan, R.; Cats, A.

doi:10.1136/ard.35.5.451

Cited by 41 publications

(11 citation statements)

References 15 publications

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“…The most probable explanation for the predominance of T lymphocytes in EVF is that only recirculating (T) cells usually pass from blood to these fluids, as supposed by Van de Putte et al [1976] in discussing their findings in synovial fluids and our data [Manconi et al, 1976] on CSF. The finding that the majority of these T cells bear IgG Fc receptors is more difficult to explain, since the immunological role of this lym phocyte subpopulation is at present uncer tain.…”

Section: Discussionmentioning

confidence: 84%

“…The find ing was considered by the authors to be re lated to cell-mediated immunity in this dis ease. Van de Putte et al [1976] noted high predominance of T cells in non-rheumatoid synovial fluids as well. A large predomi nance of T over B lymphocytes in human cerebrospinal fluid (CSF) was recently dem onstrated by our group [Manconi et al, 1976].…”

Section: Introductionmentioning

confidence: 99%

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Subpopulations of T Lymphocytes in Human Extravascular Fluids

Manconi¹,

Fadda²,

Cadoni³

et al. 1978

Int Arch Allergy Immunol

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Surface markers of lymphocytes from various human extravascular fluids (cerebrospinal fluid, aqueous humour, colostrum, breast and ovary cyst fluids, peritoneal and pleural transudates) are compared with those of lymphocytes from peripheral blood. Significantly higher percentages of T cells are found in all extravascular fluids: the great majority of extravascular T lymphocytes show high E rosette-forming ability and bear IgG Fc receptors (T Fc⁺ cells). Functional implications of the shown high predominance of T Fc⁺ cells in extravascular fluids are discussed on the basis of presently available information on the immunological role of such cells (cytotoxic? suppressor? amplifier?).

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Subpopulations of T Lymphocytes in Human Extravascular Fluids

Manconi¹,

Fadda²,

Cadoni³

et al. 1978

Int Arch Allergy Immunol

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“…This conclusion was supported by subsequent investigations. For example, the percentage of T cells in the synovial fluid of OA patients was found to be significantly higher than that in their peripheral blood (34), and T cells in the synovial fluid of OA patients expressed class II HLA (an indicator of activated T cells) (35). The percentages of CD4 + and CD8 + cells in the synovial fluid of OA patients were even similar to those found in RA patients (31).…”

Section: T Cells and Oamentioning

confidence: 99%

T Cells in Osteoarthritis: Alterations and Beyond

et al. 2017

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Although osteoarthritis (OA) has been traditionally regarded as a non-inflammatory disease, reports increasingly suggest that it is inflammatory, at least in certain patients. OA patients often exhibit inflammatory infiltration of synovial membranes by macrophages, T cells, mast cells, B cells, plasma cells, natural killer cells, dendritic cells, granulocytes, etc. Although previous reviews have summarized the knowledge of inflammation in the pathogenesis of OA, as far as we know, no report review our current understanding about T cells, especially, each T cell subtype, in the biology of OA. This review highlights the current understanding of the role of T cells in the pathogenesis of OA, with attention to Th1 cells, Th2 cells, Th9 cells, Th17 cells, Th22 cells, regulatory T cells, follicular helper T cells, cytotoxic T cells, T memory cells, and even unconventional T cells (e.g., γδ T cells and cluster of differentiation 1 restricted T cells). The findings highlight the importance of T cells to the development and progression of OA and suggest new therapeutic approaches for OA patients based on the manipulation of T-cell responses.

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“…With respect to the above-mentioned possible causative agents, the adaptive immune system plays a significant role in the phase of initiation (or activation) of the disease: T cells (12), B cells (13), and antigenpresenting cells (i.e., macrophages) (12) interact with one another, attempting to eliminate causative agents. The importance of adaptive immune processes is exemplified by the known association between HLA class II alloantigens and RA (14), including the concept of shared epitopes (15).…”

Section: Presently Known Aspects Of the Pathogenesis Of Ramentioning

confidence: 99%