Subpopulations of T Lymphocytes in Human Extravascular Fluids

Abstract

Surface markers of lymphocytes from various human extravascular fluids (cerebrospinal fluid, aqueous humour, colostrum, breast and ovary cyst fluids, peritoneal and pleural transudates) are compared with those of lymphocytes from peripheral blood. Significantly higher percentages of T cells are found in all extravascular fluids: the great majority of extravascular T lymphocytes show high E rosette-forming ability and bear IgG Fc receptors (T Fc⁺ cells). Functional implications of the shown high predominance of T Fc⁺ cells in extravascular fluids are discussed on the basis of presently available information on the immunological role of such cells (cytotoxic? suppressor? amplifier?).

CSF Anomalies in Children Affected by Epilepsia Partialis Continua (EPC)

“…Neuropediatrics 21 (1990) 145 The study shows a net decrease in the percentage of mature "T-cells" and a change in their morphology, by comparison with that which is characteristic of "Iarge granular lymphocytes" already described by Manconi et al (8): therefore, such result can confirm that in this type of EPC, besides a disorder of the gamma-globulins, a significant impairment of the CSF lymphocyte population can be detected. The small number of CSF cells does not permit 10 analyse more than one maker at a time and hinders such studies greatly; it is possible that an adjustment of the methodology with the use of a cytofluorimetry laser will allow us to acquire valuable new information.…”

“…The typification of the lymphocytic population of the CSF in anormal subject is difficult from a technical point of view because of the low number of cells present (8,9,10). The methodology (8,9,10) we used permitted us to observe that normally about 90-95 % of the CSF lymphocytes consist of mature T -cells with receptors for Fc of IgG (S. C. T-gamma) and phenotype Ts (T -cytotoxic -suppressor).…”

“…The methodology (8,9,10) we used permitted us to observe that normally about 90-95 % of the CSF lymphocytes consist of mature T -cells with receptors for Fc of IgG (S. C. T-gamma) and phenotype Ts (T -cytotoxic -suppressor).…”

Accumulation of T cells and local antippd antibody production in lymphokine‐mediated chronic peritoneal inflammation in the guinea pig

“…Our finding that relatively few B cells contributed to the inflammatory exudates in both FCA-C and NPI-C guinea pigs, is in keeping with results obtained in human studies. High T cell predominance was found in synovial fluids (van de Putte et af., 1976) and in a large variety of other extravascular fluids (Manconi et al, 1978). The higher percentage of T cells in inflammatory exudates as compared to the peripheral blood is probably mainly caused by a difference in migratory capacity of T and B cells.…”

Decrease of E and EA but Not EAC Rosette Formation after Incubation of Blood Lymphocytes in Cerebrospinal Fluid

“…In contrast, the proportion of cells in CSF with receptors for the Fc portion of IgG (erythrocyte antibody RFC; EA-RFC), is not significantly different from that of blood [Ncess, 1982a, c]. The increase in E-RFC in CSF parallels the situation regarding other body fluids, as for instance peritoneal and pleural transudates [Manconi et al, 1978]. However, the mechanism behind this increase has not been clarified.…”