Lymphocytic Infiltration in Gliomas: Evidence of Possible Host Resistance

Ridley, Alan; Cavanagh, John

doi:10.1093/brain/94.1.117

Cited by 156 publications

(38 citation statements)

References 12 publications

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“…Based on morphological criteria after hematoxylin and eosin staining, Ridley and Cavanagh (1971) described significant lymphocyte infiltration in about a third of human postmortem glioma tissues samples. In 28% they described slight infiltration, while in 42% of tissue samples they found no evidence for lymphocyte invasion.…”

Section: Interaction Of T Lymphocytes With Gliomamentioning

confidence: 99%

The brain tumor microenvironment

Charles

Holland

Gilbertson

et al. 2011

Glia

693

327

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High-grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell-like capacity. The stem-like cells may be the cells of origin for tumor relapse. However, the tumor-associated parenchymal cells such as vascular cells, microglia, peripheral immune cells, and neural precursor cells also play a vital role in controlling the course of pathology. In this review, we describe the multiple interactions of bulk glioma cells and glioma stem cells with parenchymal cell populations and highlight the pathological impact as well as signaling pathways known for these types of cell-cell communication. The tumor-vasculature not only nourishes glioblastomas, but also provides a specialized niche for these stem-like cells. In addition, microglial cells, which can contribute up to 30% of a brain tumor mass, play a role in glioblastoma cell invasion. Moreover, non-neoplastic astrocytes can be converted into a reactive phenotype by the glioma microenvironment and can then secrete a number of factors which influences tumor biology. The young brain may have the capacity to inhibit gliomagenesis by the endogenous neural precursor cells, which secrete tumor suppressive factors. The factors, pathways, and interactions described in this review provide a new prospective on the cell biology of primary brain tumors, which may ultimately generate new treatment modalities. However, our picture of the multiple interactions between parenchymal and tumor cells is still incomplete. V

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Section: Interaction Of T Lymphocytes With Gliomamentioning

confidence: 99%

The brain tumor microenvironment

Charles

Holland

Gilbertson

et al. 2011

Glia

693

327

View full text Add to dashboard Cite

show abstract

“…The brain, which lacks a conventional lymphatic system and has a so-called blood-brain barrier, has for many years been regarded as an "immunologically privileged site" (Medawar, 1948;Scheinberg et al, 1964Scheinberg et al, , 1965Morantz et al, 1978). Recently, perivascular lymphocytic cuffs have been described in histological sections of human gliomas (Ridley & Cavanagh, 1971;Takeuchi & Barnard, 1976;Palma et al, 1978) and macrophages have been isolated from brain tumours .…”

mentioning

confidence: 99%

Lymphoreticular cells in human brain tumours and in normal brain

Phillips¹,

Eremin²,

Anderson³

1982

Br J Cancer

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Summary.-The present investigation, using various rosetting assays of cell suspensions prepared by mechanical disaggregation or collagenase digestion, demonstrated lymphoreticular cells in human normal brain (cerebral cortex and cerebellum) and in malignant brain tumours. The study revealed T and B lymphocytes and their subsets (bearing receptors for Fc(IgG) and C3) in 5/14 glioma suspensions, comprising < 15% of the cell population. Between 20-60% of cells in tumour suspensions morphologically resembled macrophages and s75%0 of these cells formed strong rosettes.Lymphocytes were not found in cancer-free (putatively normal) brain. Macrophages and the smaller "microglial cells" (both phagocytic, staining with sudan black, and expressing Fc(IgG) and C3 receptors) were found in normal brain in numbers similar to those in tumour suspensions, but with less rosetting avidity. These cells may be part of an immunological defence mechanism.

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“…A recent histological study has reported lymphocytic infiltration in 27 of 77 patients (35%) with Grades III or IV astrocytomata (Ridley and Cavanagh, 1971). This tissue cellular response may represent the morphological features of a host defence mechanism similar to that seen in other human tumours such as breast cancer (Hamlin, 1968;Bloom, Richardson and Field, 1970), neuroblastoma (Martin and Beckwith, 1968), seminoma (Dayan, 1966), and stomach cancer (Black, Opler and Speer, 1956).…”

Section: Resultsmentioning

confidence: 84%

Glioblastoma Multiforme: A Controlled Trial to Assess the Value of Specific Active Immunotherapy in Patients Treated by Radical Surgery and Radiotherapy

Bloom¹,

Peckham²,

Richardson³

et al. 1973

Br J Cancer

109

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Summary.-The results are reported of a randomized prospective clinical trial carried out to assess the value of specific active immunotherapy using irradiated autologous tumour cells in patients with glioblastoma multiforme treated by radical surgery and post-operative irradiation. The results in 62 patients show no statistically significant difference in survival between the group receiving adjuvant autologous tumour cells and those treated with surgery and radiotherapy alone. All 27 patients receiving tumour cells were dead at 30 months, whereas 7 of the 35 controls were alive at this time. The results were considered sufficiently discouraging to abandon the trial at this stage on the grounds that there was sufficient evidence in this study that the administration of irradiated autologous cells was of no benefit to patients with high grade astrocytomata.

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Lymphocytic Infiltration in Gliomas: Evidence of Possible Host Resistance

Cited by 156 publications

References 12 publications

The brain tumor microenvironment

The brain tumor microenvironment

Lymphoreticular cells in human brain tumours and in normal brain

Glioblastoma Multiforme: A Controlled Trial to Assess the Value of Specific Active Immunotherapy in Patients Treated by Radical Surgery and Radiotherapy

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