Lymphocytic infiltration of bronchioloalveolar adenomas in mice

Choudhury, Chandra; Kauffman, Shirley L.; Seravalli, Egilde; Durkin, Helen G.

doi:10.1016/0304-3835(83)90028-9

Cited by 4 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…I Subsequently, many investigators provided additional morphologic and ultrastructural evidence that naturally occurring and experimentally induced alveolar-bronchiolar neoplasms of mice were of alveolar Type II cell origin.2'-6 Several studies, however, noted that some neoplasms arose in or adjacent to bronchioles, suggesting a bronchiolar epithelial origin of at least some neoplasms. , 6,8,14,[17][18][19][20] Kauffman et all8 first described significant morphologic evidence for the development of Clara cell neoplasms in Swiss mice transplacentally exposed to ethylnitrosourea (ENU). These Clara cell neoplasms were tubular and papillary in histologic type and had ultrastructural evidence of Clara cell differentiation.…”

mentioning

confidence: 99%

Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occurring pulmonary neoplasms of mice

et al. 1985

View full text Add to dashboard Cite

mentioning

confidence: 99%

Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occurring pulmonary neoplasms of mice

et al. 1985

View full text Add to dashboard Cite

Spreading on the Coelomic (Peritoneal, Pleural and Pericardial) Surface

Kaiser¹

1989

Local Invasion and Spread of Cancer

View full text Add to dashboard Cite

Chemoprevention: Mouse Colon and Lung Tumor Bioassay and Modulation of Dna Methylation as a Biomarker

Pereira

Tao

Wang

et al. 2005

Experimental Lung Research

View full text Add to dashboard Cite

Lung and colon tumors were induced in A/J, C3H, and A/J X C3H (AC3) mice by administering 16 mg/kg vinyl carbamate followed by 6 weekly doses of 12 mg/kg azoxymethane (AOM). Beginning 1 week after carcinogen treatment, the mice received chemopreventive agents, dexamethasone or piroxicam, at 0.1 and 75 mg/kg in the diet, respectively. Both AOM and vinyl carbamate induces lung tumors, but only AOM induced colon tumors. The strain sensitivity for both colon and lung tumors was A/J > AC3 > C3H mice. Dexamethasone and piroxicam reduced the multiplicity of colon and lung tumors in A/J and AC3 mice, demonstrating the advantage of a combined colon and lung bioassay. The ability of budesonide, a drug that prevents mouse lung tumors, to modulate DNA methylation in vinyl carbamate-induced lung tumors was also determined. Budesonide administered for only 7 days prior to sacrifice caused a dose-dependent (0.6 to 2.4 mg/kg diet) reversal in tumors of DNA hypomethylation and hypomethylation of the insulin-like growth factor (IGF)-II gene in the differentially methylated region (DMR) 2 region of exons 4 to 5. Longer treatment with budesonide reversed hypomethylation when administered up to the time of sacrifice. These results indicate that reversal of the hypomethylation of DNA and of specific genes in lung tumors may be applicable as a surrogate end-point biomarker for chemoprevention.

show abstract

Lymphocytic infiltration of bronchioloalveolar adenomas in mice

Cited by 4 publications

References 6 publications

Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occurring pulmonary neoplasms of mice

Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occurring pulmonary neoplasms of mice

Spreading on the Coelomic (Peritoneal, Pleural and Pericardial) Surface

Chemoprevention: Mouse Colon and Lung Tumor Bioassay and Modulation of Dna Methylation as a Biomarker

Contact Info

Product

Resources

About