Lymphocytic thyroiditis in fine‐needle aspirates: Differential diagnostic aspects

Tseleni‐Balafouta, Sofia; Kyroudi-Voulgari, Aspasia; Paizi‐Biza, Penelopi; Papacharalampous, N

doi:10.1002/dc.2840050404

Cited by 16 publications

(12 citation statements)

References 7 publications

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“…FNA has a relatively high index of accuracy, sensitivity and specificity in the diagnosis of autoimmune thyroid disease (22,23). It is helpful in the differentiation of Hashimoto's thyroiditis from thyroid neoplasms (24) and other forms of lymphocytic thyroiditis (focal or peritumoral ones) (25). The difference in the thyroid cancer incidence among NTG patients, observed between the two time periods (1985-1986 and 1994-1995, 22% and 9.93% respectively, Table 3), is probably a factitious one.…”

Section: Discussionmentioning

confidence: 98%

The predominant form of non-toxic goiter in Greece is now autoimmune thyroiditis

Doufas¹,

Mastorakos²,

Chatziioannou³

et al. 1999

European Journal of Endocrinology

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Endemic non-toxic goiter (NTG) in Greece has been attributed primarily to iodine deficiency. Thirty years ago about 60% of the prepubertal boys and girls examined in endemic goiter regions presented with NTG and among them thyroid autoimmunity was rarely detected. Although iodine supplementation has corrected this deficiency during the past 30 years, new cases of NTG still appear. To evaluate the prevalence and type of NTG and the effect of iodine supplementation on them in Greece at present, we performed two cross-sectional clinical studies and a retrospective pathology one: (i) thyroid gland volume and urinary iodine excretion (UIE) were assessed in a representative sample of 1213 schoolchildren from previously endemic and non-endemic regions; (ii) serum thyroxine, tri-iodothyronine, TSH, thyroid autoantibodies (AAB) (anti-thyroid peroxidase and anti-thyroglobulin antibodies) and UIE (in 60 patients) were measured in 300 consecutive patients with NTG from Athens and Heraklion; and (iii) we compared the prevalence of autoimmunity among fine needle aspiration smears of benign thyroid pathologies performed by the same pathologist between 1985 and 1986 (975 cases) and between 1994 and 1995 (2702 cases). We found that 12.5% of the schoolchildren examined in regions with a previous history of endemic goiter had NTG, whereas this percentage was only 1.7% in areas without such a history. In Athens (61.6%) and Heraklion (58.5%) a substantial number of NTG patients were AAB positive and biochemically hypothyroid. UIE in Athens did not differ between patients with autoimmune goiter (ATG) and simple goiter. The prevalence of autoimmune stigmata in pathology smears has increased from 5.94% (years 1985-1986) to 13.91% (years 1994-1995) (P < 0.05). We conclude that: (i) the persistence of endemic goiter in regional foci despite iodine deficiency correction suggests a possible role for a naturally occurring goitrogen; (ii) ATG is the predominant form of NTG in Greece nowadays; and (iii) the five-fold decrease in the prevalence of NTG during the past 30 years followed by the increase of ATG may support the relative character of the latter.

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Section: Discussionmentioning

confidence: 98%

The predominant form of non-toxic goiter in Greece is now autoimmune thyroiditis

Doufas¹,

Mastorakos²,

Chatziioannou³

et al. 1999

European Journal of Endocrinology

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“…There are some pitfalls when making a primary diagnosis of HT on FNAB samples, especially when there is an associated lesion. 1,4,7,13,16 Distinguishing HT from a thyroid neoplasm can also be challenging on an aspirate. HT and cell changes associated with HT can be mistaken for a Hürthle cell neoplasm, resulting in a false positive diagnosis.…”

Section: Resultsmentioning

confidence: 99%

Fine Needle Aspiration Biopsy of Hashimoto’s Thyroiditis

MacDonald

Yazdi²

1999

Acta Cytologica

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“…In particular, the diagnosis of subacute lymphocytic thyroiditis was made, according to criteria found in literature, 35,[38][39][40][41] in the presence of a lymphoid infiltrate interspersed among normal thyrocytes, with lymphoid tangles, plasma cells and Hürthle cells absent. When both plasma and Hürthle cells were present, the diagnosis of Hashimoto's thyroiditis was suggested and evaluated with the serologic data.…”

Section: Methodsmentioning

confidence: 99%

Association of Different Pathologic Processes of the Thyroid Gland in Fine Needle Aspiration Samples

Zeppa

Benincasa²,

Lucariello³

et al. 2001

Acta Cytologica

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Lymphocytic thyroiditis in fine‐needle aspirates: Differential diagnostic aspects

Cited by 16 publications

References 7 publications

The predominant form of non-toxic goiter in Greece is now autoimmune thyroiditis

The predominant form of non-toxic goiter in Greece is now autoimmune thyroiditis

Fine Needle Aspiration Biopsy of Hashimoto’s Thyroiditis

Association of Different Pathologic Processes of the Thyroid Gland in Fine Needle Aspiration Samples

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