Lymphocytosis of large granular lymphocytes in patients with hodgkin's disease

Abstract

Clonal disorders of large granular lymphocytes (LGL) of either CD3- (NK cell) or CD 3+ (T-cell) phenotype have been described. B-cell malignancies such as hairy cell leukemia and non-Hodgkin's lymphoma have been observed in association with the T-cell type of LGL leukemia. Here we report the occurrence of LGL lymphocytosis in four patients with Hodgkin's disease. Immunophenotyping studies showed that these LGL were CD 3- in three patients and CD3+ in the other. LGL were polyclonally expanded in both patients in whom clonality could be assessed.

Variant lymphoproliferative disorder of granular lymphocytes (LDGL) following Hodgkin lymphoma

“…The association between HL and LDGL has been reported by Kingreen and colleagues on four patients [18]. None of those cases had the CD3(+), CD4(+), CD8(+) phenotype, and the proliferation was polyclonal in the two of the four cases studied.…”

Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia

“…As such, our data suggest that there may be a distinction between a monoclonal lymphocytosis and leukemic clonal proliferations. Furthermore, the strong association of T-LGL with various B-cell dyscrasia 11,[35][36][37][38][39][40] also argues for a chronic immune process that can engage multiple arms of immunity or suggests some as yet undefined constitutional or acquired dysregulation within T cells that influences the entire lymphoid compartment.…”

T-Cell Large Granular Lymphocyte Leukemia and Related Disorders

“…Other researchers have described associations between LGL leukemia and CLL [58], marginal zone lymphoma [59], and Hodgkin's disease [60]. In most cases described in the literature, both lymphoproliferative disorders were diagnosed simultaneously.…”